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Association of comprehensive mental health with incident cardiovascular disease : A prospective cohort study

Li, Huiping LU ; Li, Shu ; Yang, Hongxi ; Zhang, Yuan LU ; Xu, Fusheng ; Cao, Zhi ; Ma, Yue ; Hou, Yabing ; Borne, Yan LU and Wang, Yaogang (2022) In Journal of Affective Disorders 298. p.388-395
Abstract

BACKGROUND: Evidence is limited regarding the impact of comprehensive mental health on the risk of subsequent cardiovascular events.

OBJECTIVES: To investigate the association of mental health status with cardiovascular disease (CVD) in the UK Biobank.

METHODS: This prospective study included 339,616 participants aged 40 to 69 years who were enrolled between 2006 and 2010 and were followed up to 2020, without CVD at baseline. A mental health score was created using information about depressive symptoms, anxiety, loneliness, and neuroticism. Cardiovascular disease events ascertained through hospital inpatient. Cox models were used to estimate hazard ratios and 95% confidence intervals across mental health... (More)

BACKGROUND: Evidence is limited regarding the impact of comprehensive mental health on the risk of subsequent cardiovascular events.

OBJECTIVES: To investigate the association of mental health status with cardiovascular disease (CVD) in the UK Biobank.

METHODS: This prospective study included 339,616 participants aged 40 to 69 years who were enrolled between 2006 and 2010 and were followed up to 2020, without CVD at baseline. A mental health score was created using information about depressive symptoms, anxiety, loneliness, and neuroticism. Cardiovascular disease events ascertained through hospital inpatient. Cox models were used to estimate hazard ratios and 95% confidence intervals across mental health score.

RESULTS: During a median follow-up of 11.3 years (3.7 million person-years), we documented 22,688 CVD cases including 18,460 CHD cases and 5,070 stroke cases (some individuals were diagnosed as having both CHD and stroke). A statistically significantly increased risk of incident CVD was observed for the four mental factors individually, with adjusted hazard ratios ranging from 1.03 to 1.44. The composite score of such four mental factors was also positively associated with CVD risk in a dose-response manner, with the highest scores associated with a 1.56-fold (95% confidence interval 1.47 to 1.65), 1.61-fold (1.51 to 1.72), and 1.44-fold (1.25 to 1.67) higher CVD, CHD, and stroke risk, respectively.

CONCLUSIONS: In this large prospective study, poor mental health status was associated with an increased risk of CVD. Our results highlight the importance to jointly investigate the mental health factors in relation to the risk of CVD.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Affective Disorders
volume
298
pages
388 - 395
publisher
Elsevier
external identifiers
  • scopus:85119139440
  • pmid:34752807
ISSN
0165-0327
DOI
10.1016/j.jad.2021.11.008
language
English
LU publication?
yes
additional info
Copyright © 2021. Published by Elsevier B.V.
id
9f039db6-c963-4b77-bc69-3af603db6951
date added to LUP
2021-11-26 13:55:21
date last changed
2024-06-17 00:21:28
@article{9f039db6-c963-4b77-bc69-3af603db6951,
  abstract     = {{<p>BACKGROUND: Evidence is limited regarding the impact of comprehensive mental health on the risk of subsequent cardiovascular events.</p><p>OBJECTIVES: To investigate the association of mental health status with cardiovascular disease (CVD) in the UK Biobank.</p><p>METHODS: This prospective study included 339,616 participants aged 40 to 69 years who were enrolled between 2006 and 2010 and were followed up to 2020, without CVD at baseline. A mental health score was created using information about depressive symptoms, anxiety, loneliness, and neuroticism. Cardiovascular disease events ascertained through hospital inpatient. Cox models were used to estimate hazard ratios and 95% confidence intervals across mental health score.</p><p>RESULTS: During a median follow-up of 11.3 years (3.7 million person-years), we documented 22,688 CVD cases including 18,460 CHD cases and 5,070 stroke cases (some individuals were diagnosed as having both CHD and stroke). A statistically significantly increased risk of incident CVD was observed for the four mental factors individually, with adjusted hazard ratios ranging from 1.03 to 1.44. The composite score of such four mental factors was also positively associated with CVD risk in a dose-response manner, with the highest scores associated with a 1.56-fold (95% confidence interval 1.47 to 1.65), 1.61-fold (1.51 to 1.72), and 1.44-fold (1.25 to 1.67) higher CVD, CHD, and stroke risk, respectively.</p><p>CONCLUSIONS: In this large prospective study, poor mental health status was associated with an increased risk of CVD. Our results highlight the importance to jointly investigate the mental health factors in relation to the risk of CVD.</p>}},
  author       = {{Li, Huiping and Li, Shu and Yang, Hongxi and Zhang, Yuan and Xu, Fusheng and Cao, Zhi and Ma, Yue and Hou, Yabing and Borne, Yan and Wang, Yaogang}},
  issn         = {{0165-0327}},
  language     = {{eng}},
  pages        = {{388--395}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Affective Disorders}},
  title        = {{Association of comprehensive mental health with incident cardiovascular disease : A prospective cohort study}},
  url          = {{http://dx.doi.org/10.1016/j.jad.2021.11.008}},
  doi          = {{10.1016/j.jad.2021.11.008}},
  volume       = {{298}},
  year         = {{2022}},
}