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Structural and functional connectivity associations with anterior cingulate sulcal variability

Harper, Luke LU ; Strandberg, Olof LU ; Spotorno, Nicola LU ; Nilsson, Markus LU ; Lindberg, Olof LU ; Hansson, Oskar LU orcid and Santillo, Alexander F. LU orcid (2024) In Brain Structure and Function
Abstract

Sulcation of the anterior cingulate may be defined by presence of a paracingulate sulcus, a tertiary sulcus developing during the third gestational trimester with implications on cognitive function and disease. In this cross-sectional study we examine task-free resting state functional connectivity and diffusion-weighted tract segmentation data from a cohort of healthy adults (< 60-year-old, n = 129), exploring the impact of ipsilateral paracingulate sulcal presence on structural and functional connectivity. Presence of a left paracingulate sulcus was associated with reduced fractional anisotropy in the left cingulum bundle and the left peri-genual and dorsal bundle segments, suggesting reduced structural organisational coherence in... (More)

Sulcation of the anterior cingulate may be defined by presence of a paracingulate sulcus, a tertiary sulcus developing during the third gestational trimester with implications on cognitive function and disease. In this cross-sectional study we examine task-free resting state functional connectivity and diffusion-weighted tract segmentation data from a cohort of healthy adults (< 60-year-old, n = 129), exploring the impact of ipsilateral paracingulate sulcal presence on structural and functional connectivity. Presence of a left paracingulate sulcus was associated with reduced fractional anisotropy in the left cingulum bundle and the left peri-genual and dorsal bundle segments, suggesting reduced structural organisational coherence in these tracts. This association was not observed in the offsite temporal cingulum bundle segment. Left paracingulate sulcal presence was associated with increased left peri-genual radial diffusivity and tract volume possibly suggesting increased U-fibre density in this region. Greater network dispersity was identified in individuals with an absent left paracingulate sulcus by presence of a significant, predominantly intraregional, frontal component of resting state functional connectivity which was not present in individuals with a present left paracingulate sulcus. Seed-based functional connectivity in pre-defined networks was not associated with paracingulate sulcal presence. These results identify a novel association between sulcation and structural connectivity in a healthy adult population with implications for conditions where this variation is of interest. Presence of a left paracingulate sulcus appears to alter local structural and functional connectivity, possibly as a result of the presence of a local network reliant on short association fibres.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
Cingulate, Functional Connectivity, Paracingulate, Resting-state, Sulcation
in
Brain Structure and Function
publisher
Springer
external identifiers
  • scopus:85196387096
  • pmid:38900167
ISSN
1863-2653
DOI
10.1007/s00429-024-02812-5
language
English
LU publication?
yes
additional info
Publisher Copyright: © The Author(s) 2024.
id
9feee400-c14c-4bb6-8f87-afe8d268921d
date added to LUP
2024-07-11 08:55:49
date last changed
2024-08-08 12:19:21
@article{9feee400-c14c-4bb6-8f87-afe8d268921d,
  abstract     = {{<p>Sulcation of the anterior cingulate may be defined by presence of a paracingulate sulcus, a tertiary sulcus developing during the third gestational trimester with implications on cognitive function and disease. In this cross-sectional study we examine task-free resting state functional connectivity and diffusion-weighted tract segmentation data from a cohort of healthy adults (&lt; 60-year-old, n = 129), exploring the impact of ipsilateral paracingulate sulcal presence on structural and functional connectivity. Presence of a left paracingulate sulcus was associated with reduced fractional anisotropy in the left cingulum bundle and the left peri-genual and dorsal bundle segments, suggesting reduced structural organisational coherence in these tracts. This association was not observed in the offsite temporal cingulum bundle segment. Left paracingulate sulcal presence was associated with increased left peri-genual radial diffusivity and tract volume possibly suggesting increased U-fibre density in this region. Greater network dispersity was identified in individuals with an absent left paracingulate sulcus by presence of a significant, predominantly intraregional, frontal component of resting state functional connectivity which was not present in individuals with a present left paracingulate sulcus. Seed-based functional connectivity in pre-defined networks was not associated with paracingulate sulcal presence. These results identify a novel association between sulcation and structural connectivity in a healthy adult population with implications for conditions where this variation is of interest. Presence of a left paracingulate sulcus appears to alter local structural and functional connectivity, possibly as a result of the presence of a local network reliant on short association fibres.</p>}},
  author       = {{Harper, Luke and Strandberg, Olof and Spotorno, Nicola and Nilsson, Markus and Lindberg, Olof and Hansson, Oskar and Santillo, Alexander F.}},
  issn         = {{1863-2653}},
  keywords     = {{Cingulate; Functional Connectivity; Paracingulate; Resting-state; Sulcation}},
  language     = {{eng}},
  publisher    = {{Springer}},
  series       = {{Brain Structure and Function}},
  title        = {{Structural and functional connectivity associations with anterior cingulate sulcal variability}},
  url          = {{http://dx.doi.org/10.1007/s00429-024-02812-5}},
  doi          = {{10.1007/s00429-024-02812-5}},
  year         = {{2024}},
}