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Mechanisms for motor timing in the cerebellar cortex

Johansson, Fredrik LU ; Hesslow, Germund LU and Medina, Javier (2016) In Current Opinion in Behavioral Sciences 8. p.53-59
Abstract
In classical eyeblink conditioning a subject learns to blink to a previously neutral stimulus. This conditional response is timed to occur just before an air puff to the eye. The learning is known to depend on the cerebellar cortex where Purkinje cells respond with adaptively timed pauses in their spontaneous firing. The pauses in the inhibitory Purkinje cells cause disinhibition of the cerebellar nuclei, which elicit the overt blinks. The timing of a Purkinje cell response was previously thought to require a temporal code in the input signal but recent work suggests that the Purkinje cells can learn to time their responses through an intrinsic mechanism that is activated by metabotropic glutamate receptors (mGluR7).
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Current Opinion in Behavioral Sciences
volume
8
pages
53 - 59
publisher
Elsevier
external identifiers
  • scopus:84957872448
  • pmid:26949723
ISSN
2352-1554
DOI
10.1016/j.cobeha.2016.01.013
project
Cognition, Communication and Learning
language
English
LU publication?
yes
id
9ff945f4-7b26-4c5b-a1bf-371efe2f06f6 (old id 8593658)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26949723
date added to LUP
2016-03-17 09:29:55
date last changed
2017-01-01 05:41:34
@article{9ff945f4-7b26-4c5b-a1bf-371efe2f06f6,
  abstract     = {In classical eyeblink conditioning a subject learns to blink to a previously neutral stimulus. This conditional response is timed to occur just before an air puff to the eye. The learning is known to depend on the cerebellar cortex where Purkinje cells respond with adaptively timed pauses in their spontaneous firing. The pauses in the inhibitory Purkinje cells cause disinhibition of the cerebellar nuclei, which elicit the overt blinks. The timing of a Purkinje cell response was previously thought to require a temporal code in the input signal but recent work suggests that the Purkinje cells can learn to time their responses through an intrinsic mechanism that is activated by metabotropic glutamate receptors (mGluR7).},
  author       = {Johansson, Fredrik and Hesslow, Germund and Medina, Javier},
  issn         = {2352-1554},
  language     = {eng},
  pages        = {53--59},
  publisher    = {Elsevier},
  series       = {Current Opinion in Behavioral Sciences},
  title        = {Mechanisms for motor timing in the cerebellar cortex},
  url          = {http://dx.doi.org/10.1016/j.cobeha.2016.01.013},
  volume       = {8},
  year         = {2016},
}