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Association between cardiovascular disease- and inflammation-related serum biomarkers and poor lung function in elderly

Egervall, K. LU orcid ; Rosso, A. LU and Elmståhl, S. LU (2021) In Clinical Proteomics 18(1).
Abstract

Background: Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and reduced lung function is an important risk factor for CVD and CVD-related death. However, the mechanisms behind the increased risk for CVD in COPD patients are not fully understood. Methods: We examined the association between CVD- and inflammation-related serum biomarkers, and pulmonary function in a geriatric population. 266 biomarkers related to CVD and inflammation were analyzed in blood samples from 611 subjects aged 66–86 years who participated in the Good Aging in Skåne study. Serum levels were assessed by a proximity extension assay. Pulmonary function was measured using the lower limit of normality (LLN)... (More)

Background: Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and reduced lung function is an important risk factor for CVD and CVD-related death. However, the mechanisms behind the increased risk for CVD in COPD patients are not fully understood. Methods: We examined the association between CVD- and inflammation-related serum biomarkers, and pulmonary function in a geriatric population. 266 biomarkers related to CVD and inflammation were analyzed in blood samples from 611 subjects aged 66–86 years who participated in the Good Aging in Skåne study. Serum levels were assessed by a proximity extension assay. Pulmonary function was measured using the lower limit of normality (LLN) spirometry criteria, i.e., forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) < LLN. Logistic regression models were implemented and multiple comparisons were accounted for. Results: 10.3% of the study participants fulfilled pulmonary function decline criteria according to LLN. Out of the 266 biomarkers, only plasminogen activator, urokinase receptor (PLAUR) was statistically significantly associated with decreased pulmonary function. We could not find a statistically significant association between pulmonary function decline and other biomarkers previously linked to COPD, such as interleukin 6, tumor necrosis factor and surfactant protein D. Conclusion: We found that serum levels of PLAUR are associated with pulmonary function decline in older adults. PLAUR is activated following inflammation and promotes matrix metallopeptidase (MMP) activation and extracellular matrix (ECM) degradation. This implies that PLAUR could play a role in the early phase of COPD pathogenesis.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular disease, Inflammation, Lung function decline, Proteomics
in
Clinical Proteomics
volume
18
issue
1
article number
23
publisher
Humana Press
external identifiers
  • scopus:85115881758
  • pmid:34583636
ISSN
1542-6416
DOI
10.1186/s12014-021-09329-7
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021, The Author(s).
id
a0467f97-cbbc-4ff2-9e65-72476032f3af
date added to LUP
2021-11-19 09:00:03
date last changed
2024-04-20 16:42:00
@article{a0467f97-cbbc-4ff2-9e65-72476032f3af,
  abstract     = {{<p>Background: Cardiovascular disease (CVD) is a common comorbidity in chronic obstructive pulmonary disease (COPD) and reduced lung function is an important risk factor for CVD and CVD-related death. However, the mechanisms behind the increased risk for CVD in COPD patients are not fully understood. Methods: We examined the association between CVD- and inflammation-related serum biomarkers, and pulmonary function in a geriatric population. 266 biomarkers related to CVD and inflammation were analyzed in blood samples from 611 subjects aged 66–86 years who participated in the Good Aging in Skåne study. Serum levels were assessed by a proximity extension assay. Pulmonary function was measured using the lower limit of normality (LLN) spirometry criteria, i.e., forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) &lt; LLN. Logistic regression models were implemented and multiple comparisons were accounted for. Results: 10.3% of the study participants fulfilled pulmonary function decline criteria according to LLN. Out of the 266 biomarkers, only plasminogen activator, urokinase receptor (PLAUR) was statistically significantly associated with decreased pulmonary function. We could not find a statistically significant association between pulmonary function decline and other biomarkers previously linked to COPD, such as interleukin 6, tumor necrosis factor and surfactant protein D. Conclusion: We found that serum levels of PLAUR are associated with pulmonary function decline in older adults. PLAUR is activated following inflammation and promotes matrix metallopeptidase (MMP) activation and extracellular matrix (ECM) degradation. This implies that PLAUR could play a role in the early phase of COPD pathogenesis.</p>}},
  author       = {{Egervall, K. and Rosso, A. and Elmståhl, S.}},
  issn         = {{1542-6416}},
  keywords     = {{Cardiovascular disease; Inflammation; Lung function decline; Proteomics}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{1}},
  publisher    = {{Humana Press}},
  series       = {{Clinical Proteomics}},
  title        = {{Association between cardiovascular disease- and inflammation-related serum biomarkers and poor lung function in elderly}},
  url          = {{http://dx.doi.org/10.1186/s12014-021-09329-7}},
  doi          = {{10.1186/s12014-021-09329-7}},
  volume       = {{18}},
  year         = {{2021}},
}