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Enterohemorrhagic Escherichia coli Pathogenesis and the Host Response

Karpman, Diana LU and Ståhl, Anne-Lie LU (2014) In Microbiology spectrum 2(5).
Abstract

Enterohemorrhagic Escherichia coli (EHEC) is a highly pathogenic bacterial strain capable of causing watery or bloody diarrhea, the latter termed hemorrhagic colitis, and hemolytic-uremic syndrome (HUS). HUS is defined as the simultaneous development of non-immune hemolytic anemia, thrombocytopenia, and acute renal failure. The mechanism by which EHEC bacteria colonize and cause severe colitis, followed by renal failure with activated blood cells, as well as neurological symptoms, involves the interaction of bacterial virulence factors and specific pathogen-associated molecular patterns with host cells as well as the host response. The innate immune host response comprises the release of antimicrobial peptides as well as cytokines and... (More)

Enterohemorrhagic Escherichia coli (EHEC) is a highly pathogenic bacterial strain capable of causing watery or bloody diarrhea, the latter termed hemorrhagic colitis, and hemolytic-uremic syndrome (HUS). HUS is defined as the simultaneous development of non-immune hemolytic anemia, thrombocytopenia, and acute renal failure. The mechanism by which EHEC bacteria colonize and cause severe colitis, followed by renal failure with activated blood cells, as well as neurological symptoms, involves the interaction of bacterial virulence factors and specific pathogen-associated molecular patterns with host cells as well as the host response. The innate immune host response comprises the release of antimicrobial peptides as well as cytokines and chemokines in addition to activation and/or injury to leukocytes, platelets, and erythrocytes and activation of the complement system. Some of the bacterial interactions with the host may be protective in nature, but, when excessive, contribute to extensive tissue injury, inflammation, and thrombosis, effects that may worsen the clinical outcome of EHEC infection. This article describes aspects of the host response occurring during EHEC infection and their effects on specific organs.

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organization
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Contribution to journal
publication status
published
subject
keywords
Cytokines, Diarrhea, Enterohemorrhagic Escherichia coli, Escherichia coli Infections, Hemolytic-Uremic Syndrome, Humans, Inflammation, Nervous System Diseases, Virulence, Virulence Factors, Journal Article
in
Microbiology spectrum
volume
2
issue
5
publisher
American Society for Microbiology
external identifiers
  • scopus:84940397577
ISSN
2165-0497
DOI
10.1128/microbiolspec.EHEC-0009-2013
language
English
LU publication?
yes
id
a0885445-5f48-4889-b7ed-aacc71270dfe
date added to LUP
2017-02-08 15:48:30
date last changed
2017-10-22 05:26:13
@article{a0885445-5f48-4889-b7ed-aacc71270dfe,
  abstract     = {<p>Enterohemorrhagic Escherichia coli (EHEC) is a highly pathogenic bacterial strain capable of causing watery or bloody diarrhea, the latter termed hemorrhagic colitis, and hemolytic-uremic syndrome (HUS). HUS is defined as the simultaneous development of non-immune hemolytic anemia, thrombocytopenia, and acute renal failure. The mechanism by which EHEC bacteria colonize and cause severe colitis, followed by renal failure with activated blood cells, as well as neurological symptoms, involves the interaction of bacterial virulence factors and specific pathogen-associated molecular patterns with host cells as well as the host response. The innate immune host response comprises the release of antimicrobial peptides as well as cytokines and chemokines in addition to activation and/or injury to leukocytes, platelets, and erythrocytes and activation of the complement system. Some of the bacterial interactions with the host may be protective in nature, but, when excessive, contribute to extensive tissue injury, inflammation, and thrombosis, effects that may worsen the clinical outcome of EHEC infection. This article describes aspects of the host response occurring during EHEC infection and their effects on specific organs.</p>},
  author       = {Karpman, Diana and Ståhl, Anne-Lie},
  issn         = {2165-0497},
  keyword      = {Cytokines,Diarrhea,Enterohemorrhagic Escherichia coli,Escherichia coli Infections,Hemolytic-Uremic Syndrome,Humans,Inflammation,Nervous System Diseases,Virulence,Virulence Factors,Journal Article},
  language     = {eng},
  number       = {5},
  publisher    = {American Society for Microbiology},
  series       = {Microbiology spectrum},
  title        = {Enterohemorrhagic Escherichia coli Pathogenesis and the Host Response},
  url          = {http://dx.doi.org/10.1128/microbiolspec.EHEC-0009-2013},
  volume       = {2},
  year         = {2014},
}