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Difference in Performance of EPI Pigs Fed Either Lipase-Predigested or Creon®-Supplemented Semielemental Diet

Pierzynowski, Stefan G. LU ; Socha-Banasiak, Anna ; Sobol, Monika ; Skiba, Grzegorz ; Raj, Stanisława ; Dovban, Olena LU ; Ushakova, Galyna ; Woliński, Jarosław LU ; Mosiichuk, Nadiia LU and Szczurek-Janicka, Paulina LU , et al. (2021) In BioMed Research International 2021.
Abstract

Pancreatic enzyme replacement therapy (PERT) and fat predigestion are key in ensuring the optimal growth of patients with cystic fibrosis. Our study attempted to highlight differences between fat predigestion and conventional PERT on body composition of young pigs with exocrine pancreatic insufficiency (EPI). EPI and healthy pigs were fed with high-fat diet for six weeks. During the last two weeks of the study, all pigs received additional nocturnal alimentation with Peptamen AF (PAF) and were divided into three groups: H - healthy pigs receiving PAF; P - EPI pigs receiving PAF+PERT; and L - EPI pigs receiving PAF predigested with an immobilized microbial lipase. Additional nocturnal alimentation increased the body weight gain of EPI... (More)

Pancreatic enzyme replacement therapy (PERT) and fat predigestion are key in ensuring the optimal growth of patients with cystic fibrosis. Our study attempted to highlight differences between fat predigestion and conventional PERT on body composition of young pigs with exocrine pancreatic insufficiency (EPI). EPI and healthy pigs were fed with high-fat diet for six weeks. During the last two weeks of the study, all pigs received additional nocturnal alimentation with Peptamen AF (PAF) and were divided into three groups: H - healthy pigs receiving PAF; P - EPI pigs receiving PAF+PERT; and L - EPI pigs receiving PAF predigested with an immobilized microbial lipase. Additional nocturnal alimentation increased the body weight gain of EPI pigs with better efficacy in P pigs. Humerus length and area in pigs in groups L and P were lower than that observed in pigs in group H (p value 0.005-0.088). However, bone mineral density and strength were significantly higher in P and L as compared to that of H pigs (p value 0.0026-0.0739). The gut structure was improved in P pigs. The levels of neurospecific proteins measured in the brain were mainly affected in P and less in L pigs as compared to H pigs. The beneficial effects of the nocturnal feeding with the semielemental diet in the prevention of EPI pigs' growth/development retardation are differently modified by PERT or fat predigestion in terms of growth, bone properties, neurospecific protein distribution, and gut structure.

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type
Contribution to journal
publication status
published
subject
in
BioMed Research International
volume
2021
article number
6647734
publisher
Hindawi Limited
external identifiers
  • scopus:85111107142
  • pmid:34307664
ISSN
2314-6133
DOI
10.1155/2021/6647734
language
English
LU publication?
yes
id
a088f533-cd41-4c1c-9d68-3abbcdbcc84c
date added to LUP
2022-03-03 16:34:24
date last changed
2024-03-21 05:44:51
@article{a088f533-cd41-4c1c-9d68-3abbcdbcc84c,
  abstract     = {{<p>Pancreatic enzyme replacement therapy (PERT) and fat predigestion are key in ensuring the optimal growth of patients with cystic fibrosis. Our study attempted to highlight differences between fat predigestion and conventional PERT on body composition of young pigs with exocrine pancreatic insufficiency (EPI). EPI and healthy pigs were fed with high-fat diet for six weeks. During the last two weeks of the study, all pigs received additional nocturnal alimentation with Peptamen AF (PAF) and were divided into three groups: H - healthy pigs receiving PAF; P - EPI pigs receiving PAF+PERT; and L - EPI pigs receiving PAF predigested with an immobilized microbial lipase. Additional nocturnal alimentation increased the body weight gain of EPI pigs with better efficacy in P pigs. Humerus length and area in pigs in groups L and P were lower than that observed in pigs in group H (p value 0.005-0.088). However, bone mineral density and strength were significantly higher in P and L as compared to that of H pigs (p value 0.0026-0.0739). The gut structure was improved in P pigs. The levels of neurospecific proteins measured in the brain were mainly affected in P and less in L pigs as compared to H pigs. The beneficial effects of the nocturnal feeding with the semielemental diet in the prevention of EPI pigs' growth/development retardation are differently modified by PERT or fat predigestion in terms of growth, bone properties, neurospecific protein distribution, and gut structure. </p>}},
  author       = {{Pierzynowski, Stefan G. and Socha-Banasiak, Anna and Sobol, Monika and Skiba, Grzegorz and Raj, Stanisława and Dovban, Olena and Ushakova, Galyna and Woliński, Jarosław and Mosiichuk, Nadiia and Szczurek-Janicka, Paulina and Pieszka, Marek and Kamyczek, Marian and Świȩch, Ewa and Shmigel, Halyna and Sonta, Marcin and Czkwianianc, Elżbieta and Pierzynowska, Kateryna}},
  issn         = {{2314-6133}},
  language     = {{eng}},
  publisher    = {{Hindawi Limited}},
  series       = {{BioMed Research International}},
  title        = {{Difference in Performance of EPI Pigs Fed Either Lipase-Predigested or Creon®-Supplemented Semielemental Diet}},
  url          = {{http://dx.doi.org/10.1155/2021/6647734}},
  doi          = {{10.1155/2021/6647734}},
  volume       = {{2021}},
  year         = {{2021}},
}