Hubbing the cancer cell
(2022) In Cancers 14(23).- Abstract
Simple Summary
Cancer originates from changes in the genetics of single cells that affect their proliferative rate. To cope with the increased demand of building blocks and energy, tumor cells undergo adaptive changes creating new cellular homeostasis. These newly acquired traits are used clinically as diagnostic markers. Here, we summarize our knowledge of how a cell can adjust to new energetic demands during the transformation into a tumor cell.
Abstract
Oncogenic transformation drives adaptive changes in a growing tumor that affect the cellular organization of cancerous cells, resulting in the loss of specialized cellular functions in the polarized compartmentalization of cells. The resulting altered metabolic and... (More)
Simple Summary
Cancer originates from changes in the genetics of single cells that affect their proliferative rate. To cope with the increased demand of building blocks and energy, tumor cells undergo adaptive changes creating new cellular homeostasis. These newly acquired traits are used clinically as diagnostic markers. Here, we summarize our knowledge of how a cell can adjust to new energetic demands during the transformation into a tumor cell.
Abstract
Oncogenic transformation drives adaptive changes in a growing tumor that affect the cellular organization of cancerous cells, resulting in the loss of specialized cellular functions in the polarized compartmentalization of cells. The resulting altered metabolic and morphological patterns are used clinically as diagnostic markers. This review recapitulates the known functions of actin, microtubules and the γ-tubulin meshwork in orchestrating cell metabolism and functional cellular asymmetry.
(Less)- Abstract (Swedish)
- Oncogenic transformation drives adaptive changes in a growing tumor that affect the cellular organization of cancerous cells, resulting in the loss of specialized cellular functions in the polarized compartmentalization of cells. The resulting altered metabolic and morphological patterns are used clinically as diagnostic markers. This review recapitulates the known functions of actin, microtubules and the gamma-tubulin meshwork in orchestrating cell metabolism and functional cellular asymmetry.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a0d4ad4e-de31-42c5-ac72-0758e4875add
- author
- Zhou, Jingkai LU ; Corvaisier, Matthieu LU ; Malycheva, Darina LU and Alvarado Kristensson, Maria LU
- organization
- publishing date
- 2022-11-30
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- actin, microtubules, γ-tubulin meshwork
- in
- Cancers
- volume
- 14
- issue
- 23
- article number
- 5924
- pages
- 14 pages
- publisher
- MDPI AG
- external identifiers
-
- scopus:85143604893
- pmid:36497405
- ISSN
- 2072-6694
- DOI
- 10.3390/cancers14235924
- language
- English
- LU publication?
- yes
- id
- a0d4ad4e-de31-42c5-ac72-0758e4875add
- date added to LUP
- 2022-11-30 12:53:53
- date last changed
- 2023-03-02 03:00:09
@article{a0d4ad4e-de31-42c5-ac72-0758e4875add,
abstract = {{<br/>Simple Summary<br/>Cancer originates from changes in the genetics of single cells that affect their proliferative rate. To cope with the increased demand of building blocks and energy, tumor cells undergo adaptive changes creating new cellular homeostasis. These newly acquired traits are used clinically as diagnostic markers. Here, we summarize our knowledge of how a cell can adjust to new energetic demands during the transformation into a tumor cell.<br/>Abstract<br/>Oncogenic transformation drives adaptive changes in a growing tumor that affect the cellular organization of cancerous cells, resulting in the loss of specialized cellular functions in the polarized compartmentalization of cells. The resulting altered metabolic and morphological patterns are used clinically as diagnostic markers. This review recapitulates the known functions of actin, microtubules and the γ-tubulin meshwork in orchestrating cell metabolism and functional cellular asymmetry.<br/>}},
author = {{Zhou, Jingkai and Corvaisier, Matthieu and Malycheva, Darina and Alvarado Kristensson, Maria}},
issn = {{2072-6694}},
keywords = {{actin; microtubules; γ-tubulin meshwork}},
language = {{eng}},
month = {{11}},
number = {{23}},
publisher = {{MDPI AG}},
series = {{Cancers}},
title = {{Hubbing the cancer cell}},
url = {{http://dx.doi.org/10.3390/cancers14235924}},
doi = {{10.3390/cancers14235924}},
volume = {{14}},
year = {{2022}},
}