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Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant

Limachi, Ivan LU ; Condo, Claudia ; Palma, Camila ; Nina, Nelida ; Salamanca, Efrain ; Ticona, Juan C. ; Udaeta, Enrique ; Flores, Ninoska ; Serato, Alcides and Marupa, Natalio , et al. (2019) In Natural Product Communications 14(1). p.55-58
Abstract

A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bolivia, Cytotoxicity, Giardia lamblia, Hyptis brevipes, Leishmania spp, Plasmodium falciparum, Tacana, Trypanosoma cruzi
in
Natural Product Communications
volume
14
issue
1
pages
4 pages
publisher
Natural Products Inc
external identifiers
  • scopus:85063748149
ISSN
1934-578X
DOI
10.1177/1934578X1901400115
language
English
LU publication?
yes
id
a155d1fe-5c8b-4782-b5be-c4a85923fb44
date added to LUP
2019-04-23 13:57:00
date last changed
2022-06-13 18:02:30
@article{a155d1fe-5c8b-4782-b5be-c4a85923fb44,
  abstract     = {{<p>A bioassay screening against protozoa parasites of several Tacana medicinal plants gave Hyptis brevipes (Id'ene eidhue), traditionally used as decoction for intestinal parasites, as the most active extract. In this work we did a bioguided isolation of active constituents found in leaves. Structure elucidation was carried out by NMR spectroscopy and MS spectrometry analyses. Active constituents showed differentiated activity towards Giardia lamblia, Trypanosoma cruzi, several Leishmania strains, Plasmodium falciparum and cytotoxicity against HeLa cells. Brevipolide H (1) was the less cytotoxic and best antiparasitic, while the catechol derivative (2) the most active and cytotoxic.</p>}},
  author       = {{Limachi, Ivan and Condo, Claudia and Palma, Camila and Nina, Nelida and Salamanca, Efrain and Ticona, Juan C. and Udaeta, Enrique and Flores, Ninoska and Serato, Alcides and Marupa, Natalio and Chao, Benigno and Ibaguari, Gladys and Nay, Constantino and Manner, Soffie and Sterner, Olov and Giménez, Alberto}},
  issn         = {{1934-578X}},
  keywords     = {{Bolivia; Cytotoxicity; Giardia lamblia; Hyptis brevipes; Leishmania spp; Plasmodium falciparum; Tacana; Trypanosoma cruzi}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{55--58}},
  publisher    = {{Natural Products Inc}},
  series       = {{Natural Product Communications}},
  title        = {{Antiparasitic metabolites from hyptis brevipes, a tacana medicinal plant}},
  url          = {{http://dx.doi.org/10.1177/1934578X1901400115}},
  doi          = {{10.1177/1934578X1901400115}},
  volume       = {{14}},
  year         = {{2019}},
}