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First European Case of Simultaneous Liver and Pancreas Transplantation as Treatment of Wolcott-Rallison Syndrome in a Small Child

Nordström, Johan ; Lundgren, Markus LU ; Jorns, Carl ; Fischler, Björn ; Arnell, Henrik ; Dlugosz, Rafal ; Sandberg, John ; Wennberg, Lars and Nowak, Greg (2020) In Transplantation 104(3). p.522-525
Abstract

BACKGROUND: The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise. Liver transplantation is essential for survival of patients with WRS, and pancreas transplantation cures their type I diabetes mellitus. METHODS: The recipient, a 3-year-old girl weighing 14 kg at the time of transplantation, suffered from major complications of WRS, including repetitive liver failure episodes and poorly controlled diabetes. The patient underwent a nonacute, combined, simultaneous liver and pancreas transplantation from a pediatric donor without using the en bloc technique. RESULTS: Well-preserved graft functions at 2-year follow-up with normal liver and... (More)

BACKGROUND: The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise. Liver transplantation is essential for survival of patients with WRS, and pancreas transplantation cures their type I diabetes mellitus. METHODS: The recipient, a 3-year-old girl weighing 14 kg at the time of transplantation, suffered from major complications of WRS, including repetitive liver failure episodes and poorly controlled diabetes. The patient underwent a nonacute, combined, simultaneous liver and pancreas transplantation from a pediatric donor without using the en bloc technique. RESULTS: Well-preserved graft functions at 2-year follow-up with normal liver and pancreas function. CONCLUSIONS: This is the first case report of simultaneous liver and pancreas transplantation as treatment of WRS in a small child in Europe. Two-year follow-up demonstrates that organ transplantation can halt life-threating recurrent liver failure episodes and cure type 1 diabetes.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Transplantation
volume
104
issue
3
pages
4 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:31335762
  • scopus:85080837034
ISSN
1534-6080
DOI
10.1097/TP.0000000000002869
language
English
LU publication?
yes
id
a1781161-6cdd-4450-a71c-867d49e63124
date added to LUP
2020-03-18 10:17:39
date last changed
2024-04-03 04:38:11
@article{a1781161-6cdd-4450-a71c-867d49e63124,
  abstract     = {{<p>BACKGROUND: The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise. Liver transplantation is essential for survival of patients with WRS, and pancreas transplantation cures their type I diabetes mellitus. METHODS: The recipient, a 3-year-old girl weighing 14 kg at the time of transplantation, suffered from major complications of WRS, including repetitive liver failure episodes and poorly controlled diabetes. The patient underwent a nonacute, combined, simultaneous liver and pancreas transplantation from a pediatric donor without using the en bloc technique. RESULTS: Well-preserved graft functions at 2-year follow-up with normal liver and pancreas function. CONCLUSIONS: This is the first case report of simultaneous liver and pancreas transplantation as treatment of WRS in a small child in Europe. Two-year follow-up demonstrates that organ transplantation can halt life-threating recurrent liver failure episodes and cure type 1 diabetes.</p>}},
  author       = {{Nordström, Johan and Lundgren, Markus and Jorns, Carl and Fischler, Björn and Arnell, Henrik and Dlugosz, Rafal and Sandberg, John and Wennberg, Lars and Nowak, Greg}},
  issn         = {{1534-6080}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{522--525}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Transplantation}},
  title        = {{First European Case of Simultaneous Liver and Pancreas Transplantation as Treatment of Wolcott-Rallison Syndrome in a Small Child}},
  url          = {{http://dx.doi.org/10.1097/TP.0000000000002869}},
  doi          = {{10.1097/TP.0000000000002869}},
  volume       = {{104}},
  year         = {{2020}},
}