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Chemoenzymatic Synthesis of Glycopeptides Bearing Galactose-Xylose Disaccharide from the Proteoglycan Linkage Region

Gao, Jia ; Lin, Po Han ; Nick, Setare Tahmasebi ; Huang, Junfeng ; Tykesson, Emil LU orcid ; Ellervik, Ulf LU ; Li, Lingjun and Huang, Xuefei (2021) In Organic Letters 23(5). p.1738-1741
Abstract

Proteoglycans have important biological activities. To improve the overall synthetic efficiency, a new chemoenzymatic route has been established for the proteoglycan linkage region bearing a galactose-xylose disaccharide. The xylosylated glycopeptides were synthesized via solid phase synthesis, which was followed by the addition of the galactose unit by the galactosyl transferase β4GalT7. This work leads to a better understanding of the acceptor preference of β4GalT7 and opens the door for expeditious synthesis of the proteoglycan linkage region.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Organic Letters
volume
23
issue
5
pages
1738 - 1741
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85101711896
  • pmid:33576634
ISSN
1523-7060
DOI
10.1021/acs.orglett.1c00168
language
English
LU publication?
yes
id
a1fc7235-33d4-4086-9918-82945776dc1d
date added to LUP
2021-03-16 08:15:13
date last changed
2024-04-18 03:44:31
@article{a1fc7235-33d4-4086-9918-82945776dc1d,
  abstract     = {{<p>Proteoglycans have important biological activities. To improve the overall synthetic efficiency, a new chemoenzymatic route has been established for the proteoglycan linkage region bearing a galactose-xylose disaccharide. The xylosylated glycopeptides were synthesized via solid phase synthesis, which was followed by the addition of the galactose unit by the galactosyl transferase β4GalT7. This work leads to a better understanding of the acceptor preference of β4GalT7 and opens the door for expeditious synthesis of the proteoglycan linkage region.</p>}},
  author       = {{Gao, Jia and Lin, Po Han and Nick, Setare Tahmasebi and Huang, Junfeng and Tykesson, Emil and Ellervik, Ulf and Li, Lingjun and Huang, Xuefei}},
  issn         = {{1523-7060}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1738--1741}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Organic Letters}},
  title        = {{Chemoenzymatic Synthesis of Glycopeptides Bearing Galactose-Xylose Disaccharide from the Proteoglycan Linkage Region}},
  url          = {{http://dx.doi.org/10.1021/acs.orglett.1c00168}},
  doi          = {{10.1021/acs.orglett.1c00168}},
  volume       = {{23}},
  year         = {{2021}},
}