Chemoenzymatic Synthesis of Glycopeptides Bearing Galactose-Xylose Disaccharide from the Proteoglycan Linkage Region
(2021) In Organic Letters 23(5). p.1738-1741- Abstract
Proteoglycans have important biological activities. To improve the overall synthetic efficiency, a new chemoenzymatic route has been established for the proteoglycan linkage region bearing a galactose-xylose disaccharide. The xylosylated glycopeptides were synthesized via solid phase synthesis, which was followed by the addition of the galactose unit by the galactosyl transferase β4GalT7. This work leads to a better understanding of the acceptor preference of β4GalT7 and opens the door for expeditious synthesis of the proteoglycan linkage region.
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https://lup.lub.lu.se/record/a1fc7235-33d4-4086-9918-82945776dc1d
- author
- Gao, Jia ; Lin, Po Han ; Nick, Setare Tahmasebi ; Huang, Junfeng ; Tykesson, Emil LU ; Ellervik, Ulf LU ; Li, Lingjun and Huang, Xuefei
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Organic Letters
- volume
- 23
- issue
- 5
- pages
- 1738 - 1741
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:85101711896
- pmid:33576634
- ISSN
- 1523-7060
- DOI
- 10.1021/acs.orglett.1c00168
- language
- English
- LU publication?
- yes
- id
- a1fc7235-33d4-4086-9918-82945776dc1d
- date added to LUP
- 2021-03-16 08:15:13
- date last changed
- 2024-04-18 03:44:31
@article{a1fc7235-33d4-4086-9918-82945776dc1d, abstract = {{<p>Proteoglycans have important biological activities. To improve the overall synthetic efficiency, a new chemoenzymatic route has been established for the proteoglycan linkage region bearing a galactose-xylose disaccharide. The xylosylated glycopeptides were synthesized via solid phase synthesis, which was followed by the addition of the galactose unit by the galactosyl transferase β4GalT7. This work leads to a better understanding of the acceptor preference of β4GalT7 and opens the door for expeditious synthesis of the proteoglycan linkage region.</p>}}, author = {{Gao, Jia and Lin, Po Han and Nick, Setare Tahmasebi and Huang, Junfeng and Tykesson, Emil and Ellervik, Ulf and Li, Lingjun and Huang, Xuefei}}, issn = {{1523-7060}}, language = {{eng}}, number = {{5}}, pages = {{1738--1741}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Organic Letters}}, title = {{Chemoenzymatic Synthesis of Glycopeptides Bearing Galactose-Xylose Disaccharide from the Proteoglycan Linkage Region}}, url = {{http://dx.doi.org/10.1021/acs.orglett.1c00168}}, doi = {{10.1021/acs.orglett.1c00168}}, volume = {{23}}, year = {{2021}}, }