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Olika tillstånd av pulmonell hypertension ska inte förväxlas : PAH-läkemedel bör inte användas vid pulmonell hypertension på basen av vänstersidig hjärtsjukdom

Lundgren, Jakob LU and Rådegran, Göran LU (2019) In Läkartidningen 116(13).
Abstract

Pulmonary hypertension is a common consequence of left heart disease, associated with poor prognosis. The pulmonary hypertension in left heart disease is initially caused by a passive congestion of the pulmonary circuit but may, if longstanding, result in endothelial dysfunction and excessive vasoconstriction. In some cases pulmonary vascular remodeling occur, further complicating the condition and worsening the prognosis. It has been debated whether these patients may benefit from pulmonary vasodilators presently used in pulmonary arterial hypertension. Several randomized controlled trials have been performed on this subject, the vast majority being negative. As maintenance therapy may be harmful, they should be avoided outside... (More)

Pulmonary hypertension is a common consequence of left heart disease, associated with poor prognosis. The pulmonary hypertension in left heart disease is initially caused by a passive congestion of the pulmonary circuit but may, if longstanding, result in endothelial dysfunction and excessive vasoconstriction. In some cases pulmonary vascular remodeling occur, further complicating the condition and worsening the prognosis. It has been debated whether these patients may benefit from pulmonary vasodilators presently used in pulmonary arterial hypertension. Several randomized controlled trials have been performed on this subject, the vast majority being negative. As maintenance therapy may be harmful, they should be avoided outside clinical trials.

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Please use this url to cite or link to this publication:
author
and
organization
alternative title
Pulmonary hypertension due to left heart disease - not to be confused with pulmonary arterial hypertension
publishing date
type
Contribution to journal
publication status
published
subject
in
Läkartidningen
volume
116
issue
13
pages
3 pages
publisher
Swedish Medical Association
external identifiers
  • scopus:85064493367
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
a2d8eafa-a718-42c2-a787-0c46714ecad6
alternative location
http://www.lakartidningen.se/Klinik-och-vetenskap/Kommentar/2019/03/Olika-tillstand-av-pulmonell-hypertension-ska-inte-forvaxlas/
date added to LUP
2019-05-06 13:45:40
date last changed
2022-04-25 23:23:05
@article{a2d8eafa-a718-42c2-a787-0c46714ecad6,
  abstract     = {{<p>Pulmonary hypertension is a common consequence of left heart disease, associated with poor prognosis. The pulmonary hypertension in left heart disease is initially caused by a passive congestion of the pulmonary circuit but may, if longstanding, result in endothelial dysfunction and excessive vasoconstriction. In some cases pulmonary vascular remodeling occur, further complicating the condition and worsening the prognosis. It has been debated whether these patients may benefit from pulmonary vasodilators presently used in pulmonary arterial hypertension. Several randomized controlled trials have been performed on this subject, the vast majority being negative. As maintenance therapy may be harmful, they should be avoided outside clinical trials.</p>}},
  author       = {{Lundgren, Jakob and Rådegran, Göran}},
  issn         = {{0023-7205}},
  language     = {{swe}},
  number       = {{13}},
  publisher    = {{Swedish Medical Association}},
  series       = {{Läkartidningen}},
  title        = {{Olika tillstånd av pulmonell hypertension ska inte förväxlas : PAH-läkemedel bör inte användas vid pulmonell hypertension på basen av vänstersidig hjärtsjukdom}},
  url          = {{http://www.lakartidningen.se/Klinik-och-vetenskap/Kommentar/2019/03/Olika-tillstand-av-pulmonell-hypertension-ska-inte-forvaxlas/}},
  volume       = {{116}},
  year         = {{2019}},
}