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Is good muscle function a protective factor for early signs of knee osteoarthritis after anterior cruciate ligament reconstruction? : The SHIELD cohort study protocol

Cronström, Anna LU ; Risberg, May Arna ; Englund, Martin LU orcid ; Tiderius, Carl Johan LU ; Önnerfjord, Patrik LU orcid ; Struglics, André LU ; Svensson, Jonas LU ; Peterson, Pernilla LU ; Månsson, Sven LU orcid and Ageberg, Eva LU orcid (2020) In Osteoarthritis and Cartilage Open 2(4).
Abstract

INTRODUCTION: Knee injury history and increased joint load, respectively, are major risk factors for the development of knee osteoarthritis (OA). Lower extremity muscle function, such as knee muscle strength, influence joint load and may be important for the onset of knee OA. However, the role of muscle function as a possible modifiable protective mechanism for the development of OA after anterior cruciate ligament reconstruction (ACLR) is not clear.

METHODS AND ANALYSIS: In this prospective cohort study, 100 patients (50% women, 18-35 years) with ACLR will be recruited from Skåne University Hospital, Sweden and Oslo University Hospital, Norway. They will be assessed with a comprehensive test battery of muscle function including... (More)

INTRODUCTION: Knee injury history and increased joint load, respectively, are major risk factors for the development of knee osteoarthritis (OA). Lower extremity muscle function, such as knee muscle strength, influence joint load and may be important for the onset of knee OA. However, the role of muscle function as a possible modifiable protective mechanism for the development of OA after anterior cruciate ligament reconstruction (ACLR) is not clear.

METHODS AND ANALYSIS: In this prospective cohort study, 100 patients (50% women, 18-35 years) with ACLR will be recruited from Skåne University Hospital, Sweden and Oslo University Hospital, Norway. They will be assessed with a comprehensive test battery of muscle function including muscle strength, muscle activation, hop performance, and postural orientation as well as patient-reported outcomes, one year (baseline) and three years (follow-up) after ACLR. Primary predictor will be knee extension strength, primary outcome will be patient-reported knee pain (Knee injury and Osteoarthritis Outcome Score, subscale pain) and secondary outcomes include compositional MRI (T2 mapping) and turnover of cartilage and bone biomarkers. Separate linear regression model will be used to elucidate the influence of each baseline muscle function variable on the outcomes at follow-up, adjusted for baseline values. Twenty non-injured individuals will also be assessed with MRI. This study is approved by The Regional Ethical Review Board in Lund (Sweden) and Oslo (Norway).

DISCUSSION: This study may have important clinical implications for using muscle function to screen for risk of early-onset knee OA and for optimizing exercise therapy after knee injury.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Osteoarthritis, ACL injury, Muscle function, Prevention
in
Osteoarthritis and Cartilage Open
volume
2
issue
4
article number
100102
pages
7 pages
publisher
Elsevier
external identifiers
  • pmid:36474871
  • scopus:85143241135
ISSN
2665-9131
DOI
10.1016/j.ocarto.2020.100102
language
English
LU publication?
yes
additional info
© 2020 The Authors.
id
a2f4675a-3c60-4d1e-8546-1a3971020d7c
date added to LUP
2022-12-09 15:14:37
date last changed
2024-04-05 17:41:36
@article{a2f4675a-3c60-4d1e-8546-1a3971020d7c,
  abstract     = {{<p>INTRODUCTION: Knee injury history and increased joint load, respectively, are major risk factors for the development of knee osteoarthritis (OA). Lower extremity muscle function, such as knee muscle strength, influence joint load and may be important for the onset of knee OA. However, the role of muscle function as a possible modifiable protective mechanism for the development of OA after anterior cruciate ligament reconstruction (ACLR) is not clear.</p><p>METHODS AND ANALYSIS: In this prospective cohort study, 100 patients (50% women, 18-35 years) with ACLR will be recruited from Skåne University Hospital, Sweden and Oslo University Hospital, Norway. They will be assessed with a comprehensive test battery of muscle function including muscle strength, muscle activation, hop performance, and postural orientation as well as patient-reported outcomes, one year (baseline) and three years (follow-up) after ACLR. Primary predictor will be knee extension strength, primary outcome will be patient-reported knee pain (Knee injury and Osteoarthritis Outcome Score, subscale pain) and secondary outcomes include compositional MRI (T2 mapping) and turnover of cartilage and bone biomarkers. Separate linear regression model will be used to elucidate the influence of each baseline muscle function variable on the outcomes at follow-up, adjusted for baseline values. Twenty non-injured individuals will also be assessed with MRI. This study is approved by The Regional Ethical Review Board in Lund (Sweden) and Oslo (Norway).</p><p>DISCUSSION: This study may have important clinical implications for using muscle function to screen for risk of early-onset knee OA and for optimizing exercise therapy after knee injury.</p>}},
  author       = {{Cronström, Anna and Risberg, May Arna and Englund, Martin and Tiderius, Carl Johan and Önnerfjord, Patrik and Struglics, André and Svensson, Jonas and Peterson, Pernilla and Månsson, Sven and Ageberg, Eva}},
  issn         = {{2665-9131}},
  keywords     = {{Osteoarthritis; ACL injury; Muscle function; Prevention}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{Elsevier}},
  series       = {{Osteoarthritis and Cartilage Open}},
  title        = {{Is good muscle function a protective factor for early signs of knee osteoarthritis after anterior cruciate ligament reconstruction? : The SHIELD cohort study protocol}},
  url          = {{http://dx.doi.org/10.1016/j.ocarto.2020.100102}},
  doi          = {{10.1016/j.ocarto.2020.100102}},
  volume       = {{2}},
  year         = {{2020}},
}