Advanced

Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model

Rydhög, Anna LU ; Pasternak, Ofer; Ståhlberg, Freddy LU ; Ahlgren, André LU ; Knutsson, Linda LU and Wirestam, Ronnie LU (2019) In European Journal of Radiology Open 6. p.198-205
Abstract
Compartmental diffusion MRI models that account for intravoxel incoherent motion (IVIM) of blood perfusion allow for estimation of the fractional volume of the microvascular compartment. Conventional IVIM models are known to be biased by not accounting for partial volume effects caused by free water and cerebrospinal fluid (CSF), or for tissue-dependent relaxation effects. In this work, a three-compartment model (tissue, free water and blood) that includes relaxation terms is introduced. To estimate the model parameters, in vivo human data were collected with multiple echo times (TE), inversion times (TI) and b-values, which allowed a direct relaxation estimate alongside estimation of perfusion, diffusion and fractional volume parameters.... (More)
Compartmental diffusion MRI models that account for intravoxel incoherent motion (IVIM) of blood perfusion allow for estimation of the fractional volume of the microvascular compartment. Conventional IVIM models are known to be biased by not accounting for partial volume effects caused by free water and cerebrospinal fluid (CSF), or for tissue-dependent relaxation effects. In this work, a three-compartment model (tissue, free water and blood) that includes relaxation terms is introduced. To estimate the model parameters, in vivo human data were collected with multiple echo times (TE), inversion times (TI) and b-values, which allowed a direct relaxation estimate alongside estimation of perfusion, diffusion and fractional volume parameters. Compared to conventional two-compartment models (with and without relaxation compensation), the three-compartment model showed less effects of CSF contamination. The proposed model yielded significantly different volume fractions of blood and tissue compared to the non-relaxation-compensated model, as well as to the conventional two-compartment model, suggesting that previously reported parameter ranges, using models that do not account for relaxation, should be reconsidered. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Radiology Open
volume
6
pages
198 - 205
publisher
Elsevier Ltd
external identifiers
  • scopus:85066091914
ISSN
2352-0477
DOI
10.1016/j.ejro.2019.05.007
language
English
LU publication?
yes
id
a3bf8851-f3e6-44d8-96af-58a93427139f
date added to LUP
2019-05-28 12:38:23
date last changed
2019-07-02 04:46:38
@article{a3bf8851-f3e6-44d8-96af-58a93427139f,
  abstract     = {Compartmental diffusion MRI models that account for intravoxel incoherent motion (IVIM) of blood perfusion allow for estimation of the fractional volume of the microvascular compartment. Conventional IVIM models are known to be biased by not accounting for partial volume effects caused by free water and cerebrospinal fluid (CSF), or for tissue-dependent relaxation effects. In this work, a three-compartment model (tissue, free water and blood) that includes relaxation terms is introduced. To estimate the model parameters, in vivo human data were collected with multiple echo times (TE), inversion times (TI) and b-values, which allowed a direct relaxation estimate alongside estimation of perfusion, diffusion and fractional volume parameters. Compared to conventional two-compartment models (with and without relaxation compensation), the three-compartment model showed less effects of CSF contamination. The proposed model yielded significantly different volume fractions of blood and tissue compared to the non-relaxation-compensated model, as well as to the conventional two-compartment model, suggesting that previously reported parameter ranges, using models that do not account for relaxation, should be reconsidered.},
  author       = {Rydhög, Anna and Pasternak, Ofer and Ståhlberg, Freddy and Ahlgren, André and Knutsson, Linda and Wirestam, Ronnie},
  issn         = {2352-0477},
  language     = {eng},
  month        = {05},
  pages        = {198--205},
  publisher    = {Elsevier Ltd},
  series       = {European Journal of Radiology Open},
  title        = {Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model},
  url          = {http://dx.doi.org/10.1016/j.ejro.2019.05.007},
  volume       = {6},
  year         = {2019},
}