Kidney cadmium as compared to other markers of cadmium exposure in workers at a secondary metal smelter
(2001) In American Journal of Industrial Medicine 39(1). p.19-28- Abstract
- BACKGROUND: The aim of the study was to evaluate whether cadmium concentrations in kidney (K-Cd), blood (B-Cd) or urine (U-Cd) could reveal previous occupational cadmium exposure at a metal smelter. METHODS: The study included 90 smelters and 35 controls (B-Cd and U-Cd determination). In a subgroup (N = 33), K-Cd was also determined. RESULTS: B-Cd (median 4.6; range 0.5-53 nmol/L), U-Cd (0. 29; 0.04-1.9 micromol/mol creatinine) and K-Cd (14; 3-61 microg/g wet weight) were similar to reported concentrations in the general Swedish population. In the subgroup, significant associations (P<0. 001) were obtained between B-Cd and K-Cd (r = 0.70), U-Cd and K-Cd (r = 0.60) and between U-Cd and B-Cd (r = 0.62). Multiple regression analyses... (More)
- BACKGROUND: The aim of the study was to evaluate whether cadmium concentrations in kidney (K-Cd), blood (B-Cd) or urine (U-Cd) could reveal previous occupational cadmium exposure at a metal smelter. METHODS: The study included 90 smelters and 35 controls (B-Cd and U-Cd determination). In a subgroup (N = 33), K-Cd was also determined. RESULTS: B-Cd (median 4.6; range 0.5-53 nmol/L), U-Cd (0. 29; 0.04-1.9 micromol/mol creatinine) and K-Cd (14; 3-61 microg/g wet weight) were similar to reported concentrations in the general Swedish population. In the subgroup, significant associations (P<0. 001) were obtained between B-Cd and K-Cd (r = 0.70), U-Cd and K-Cd (r = 0.60) and between U-Cd and B-Cd (r = 0.62). Multiple regression analyses revealed smoking as the major predictor of K-Cd, B-Cd, and U-Cd. B-Cd and U-Cd were both associated with the duration of employment at the smelter. CONCLUSIONS: There was no statistically significant evidence of previous occupational exposure at the smelter from measurement of K-Cd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1122662
- author
- Börjesson, Jimmy ; Gerhardsson, Lars LU ; Schutz, Andrejs ; Perfekt, Roland LU ; Mattsson, Sören LU and Skerfving, Staffan LU
- organization
- publishing date
- 2001
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cadmium, smelter, lead, kidney, X-ray fluorescence, smoking
- in
- American Journal of Industrial Medicine
- volume
- 39
- issue
- 1
- pages
- 19 - 28
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:11148012
- scopus:0035153684
- ISSN
- 0271-3586
- DOI
- 10.1002/1097-0274(200101)39:1<19::AID-AJIM2>3.0.CO;2-Q
- language
- English
- LU publication?
- yes
- id
- a3fcb60f-d1a0-4156-a6e2-47c145409696 (old id 1122662)
- date added to LUP
- 2016-04-01 11:57:28
- date last changed
- 2022-01-26 20:43:57
@article{a3fcb60f-d1a0-4156-a6e2-47c145409696, abstract = {{BACKGROUND: The aim of the study was to evaluate whether cadmium concentrations in kidney (K-Cd), blood (B-Cd) or urine (U-Cd) could reveal previous occupational cadmium exposure at a metal smelter. METHODS: The study included 90 smelters and 35 controls (B-Cd and U-Cd determination). In a subgroup (N = 33), K-Cd was also determined. RESULTS: B-Cd (median 4.6; range 0.5-53 nmol/L), U-Cd (0. 29; 0.04-1.9 micromol/mol creatinine) and K-Cd (14; 3-61 microg/g wet weight) were similar to reported concentrations in the general Swedish population. In the subgroup, significant associations (P<0. 001) were obtained between B-Cd and K-Cd (r = 0.70), U-Cd and K-Cd (r = 0.60) and between U-Cd and B-Cd (r = 0.62). Multiple regression analyses revealed smoking as the major predictor of K-Cd, B-Cd, and U-Cd. B-Cd and U-Cd were both associated with the duration of employment at the smelter. CONCLUSIONS: There was no statistically significant evidence of previous occupational exposure at the smelter from measurement of K-Cd.}}, author = {{Börjesson, Jimmy and Gerhardsson, Lars and Schutz, Andrejs and Perfekt, Roland and Mattsson, Sören and Skerfving, Staffan}}, issn = {{0271-3586}}, keywords = {{cadmium; smelter; lead; kidney; X-ray fluorescence; smoking}}, language = {{eng}}, number = {{1}}, pages = {{19--28}}, publisher = {{John Wiley & Sons Inc.}}, series = {{American Journal of Industrial Medicine}}, title = {{Kidney cadmium as compared to other markers of cadmium exposure in workers at a secondary metal smelter}}, url = {{http://dx.doi.org/10.1002/1097-0274(200101)39:1<19::AID-AJIM2>3.0.CO;2-Q}}, doi = {{10.1002/1097-0274(200101)39:1<19::AID-AJIM2>3.0.CO;2-Q}}, volume = {{39}}, year = {{2001}}, }