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Maternal serum levels of perfluoroalkyl substances in early pregnancy and offspring birth weight

Wikström, Sverre ; Lin, Ping I. ; Lindh, Christian H. LU orcid ; Shu, Huan and Bornehag, Carl Gustaf (2020) In Pediatric Research 87(6). p.1093-1099
Abstract

Background: Perfluoroalkyl substances (PFASs) are widespread, bioaccumulating, and persistent and show placental transfer. Emerging research indicates associations between prenatal exposure and low birth weight. The aim of this study was to assess the associations between first trimester exposure to PFASs and birth weight (BW) in the Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy (SELMA) study and examine whether associations differ between girls and boys. Methods: Eight PFASs were analyzed in maternal serum (median: 10 weeks of pregnancy). Associations between prenatal PFAS exposure and birth outcomes with BW, BW for gestational age, and birth small for gestational age (SGA) were assessed in 1533 infants,... (More)

Background: Perfluoroalkyl substances (PFASs) are widespread, bioaccumulating, and persistent and show placental transfer. Emerging research indicates associations between prenatal exposure and low birth weight. The aim of this study was to assess the associations between first trimester exposure to PFASs and birth weight (BW) in the Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy (SELMA) study and examine whether associations differ between girls and boys. Methods: Eight PFASs were analyzed in maternal serum (median: 10 weeks of pregnancy). Associations between prenatal PFAS exposure and birth outcomes with BW, BW for gestational age, and birth small for gestational age (SGA) were assessed in 1533 infants, adjusted for potential confounders and stratified by sex. Results: Increased maternal perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) were associated with lower BW, lower BW for gestational age, and SGA birth. Associations were significant only in girls, where prenatal exposure in the upper quartile was associated with a 93–142-g lower BW when compared with that of the lowest quartile exposure. The associations were not mediated by effects on gestational age. Conclusions: We found associations between prenatal exposure for five different PFASs and birth weight, with more pronounced associations in girls than in boys.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pediatric Research
volume
87
issue
6
pages
7 pages
publisher
International Pediatric Foundation Inc.
external identifiers
  • pmid:31835271
  • scopus:85076699776
ISSN
0031-3998
DOI
10.1038/s41390-019-0720-1
language
English
LU publication?
yes
id
a3fdfac3-cfc6-4c8d-9a59-2e80c2bd1561
date added to LUP
2020-12-18 13:23:25
date last changed
2024-04-17 21:25:12
@article{a3fdfac3-cfc6-4c8d-9a59-2e80c2bd1561,
  abstract     = {{<p>Background: Perfluoroalkyl substances (PFASs) are widespread, bioaccumulating, and persistent and show placental transfer. Emerging research indicates associations between prenatal exposure and low birth weight. The aim of this study was to assess the associations between first trimester exposure to PFASs and birth weight (BW) in the Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy (SELMA) study and examine whether associations differ between girls and boys. Methods: Eight PFASs were analyzed in maternal serum (median: 10 weeks of pregnancy). Associations between prenatal PFAS exposure and birth outcomes with BW, BW for gestational age, and birth small for gestational age (SGA) were assessed in 1533 infants, adjusted for potential confounders and stratified by sex. Results: Increased maternal perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) were associated with lower BW, lower BW for gestational age, and SGA birth. Associations were significant only in girls, where prenatal exposure in the upper quartile was associated with a 93–142-g lower BW when compared with that of the lowest quartile exposure. The associations were not mediated by effects on gestational age. Conclusions: We found associations between prenatal exposure for five different PFASs and birth weight, with more pronounced associations in girls than in boys.</p>}},
  author       = {{Wikström, Sverre and Lin, Ping I. and Lindh, Christian H. and Shu, Huan and Bornehag, Carl Gustaf}},
  issn         = {{0031-3998}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1093--1099}},
  publisher    = {{International Pediatric Foundation Inc.}},
  series       = {{Pediatric Research}},
  title        = {{Maternal serum levels of perfluoroalkyl substances in early pregnancy and offspring birth weight}},
  url          = {{http://dx.doi.org/10.1038/s41390-019-0720-1}},
  doi          = {{10.1038/s41390-019-0720-1}},
  volume       = {{87}},
  year         = {{2020}},
}