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Bacterial Adherence and Epithelial Cell Cytokine Production

Svanborg, Catharina LU ; Agace, William LU ; Hedges, Spencer; Linder, Henrik and Svensson, Majlis LU (1993) In Zentralblatt fur Bakteriologie 278(2-3). p.359-364
Abstract

Epithelial cell lines produce the cytokines IL-1α, IL-6 and IL-8 when stimulated with Escherichia coli. The cytokine response is enhanced by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more active role in the mucosal immune response than previously recognized.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Zentralblatt fur Bakteriologie
volume
278
issue
2-3
pages
6 pages
publisher
Fischer
external identifiers
  • scopus:0027582287
ISSN
0934-8840
DOI
10.1016/S0934-8840(11)80852-2
language
English
LU publication?
yes
id
a4b6c697-880c-4371-8ea2-b101bba26484
date added to LUP
2019-05-30 14:00:19
date last changed
2019-08-16 14:25:37
@article{a4b6c697-880c-4371-8ea2-b101bba26484,
  abstract     = {<p>Epithelial cell lines produce the cytokines IL-1α, IL-6 and IL-8 when stimulated with Escherichia coli. The cytokine response is enhanced by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more active role in the mucosal immune response than previously recognized.</p>},
  author       = {Svanborg, Catharina and Agace, William and Hedges, Spencer and Linder, Henrik and Svensson, Majlis},
  issn         = {0934-8840},
  language     = {eng},
  month        = {01},
  number       = {2-3},
  pages        = {359--364},
  publisher    = {Fischer},
  series       = {Zentralblatt fur Bakteriologie},
  title        = {Bacterial Adherence and Epithelial Cell Cytokine Production},
  url          = {http://dx.doi.org/10.1016/S0934-8840(11)80852-2},
  volume       = {278},
  year         = {1993},
}