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Bacterial Adherence and Epithelial Cell Cytokine Production

Svanborg, Catharina LU ; Agace, William LU ; Hedges, Spencer ; Linder, Henrik and Svensson, Majlis LU (1993) In Zentralblatt fur Bakteriologie 278(2-3). p.359-364
Abstract

Epithelial cell lines produce the cytokines IL-1α, IL-6 and IL-8 when stimulated with Escherichia coli. The cytokine response is enhanced by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more active role in the mucosal immune response than previously recognized.

Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Zentralblatt fur Bakteriologie
volume
278
issue
2-3
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:0027582287
  • pmid:8347939
ISSN
0934-8840
DOI
10.1016/S0934-8840(11)80852-2
language
English
LU publication?
yes
id
a4b6c697-880c-4371-8ea2-b101bba26484
date added to LUP
2019-05-30 14:00:19
date last changed
2025-10-14 11:46:02
@article{a4b6c697-880c-4371-8ea2-b101bba26484,
  abstract     = {{<p>Epithelial cell lines produce the cytokines IL-1α, IL-6 and IL-8 when stimulated with Escherichia coli. The cytokine response is enhanced by P fimbriae. The epithelial cell lines also respond to stimulation with other cytokines. These in vitro findings were confirmed in vivo in patients with E. coli infection who secreted IL-6 and IL-8 into the urine. The observations suggest that epithelial cells play a more active role in the mucosal immune response than previously recognized.</p>}},
  author       = {{Svanborg, Catharina and Agace, William and Hedges, Spencer and Linder, Henrik and Svensson, Majlis}},
  issn         = {{0934-8840}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{2-3}},
  pages        = {{359--364}},
  publisher    = {{Elsevier}},
  series       = {{Zentralblatt fur Bakteriologie}},
  title        = {{Bacterial Adherence and Epithelial Cell Cytokine Production}},
  url          = {{http://dx.doi.org/10.1016/S0934-8840(11)80852-2}},
  doi          = {{10.1016/S0934-8840(11)80852-2}},
  volume       = {{278}},
  year         = {{1993}},
}