Purkinje cell activity during classical conditioning with different conditional stimulus explains central tenet of Rescorla-Wagner model.
Rasmussen, Anders LU
; Zucca, Riccardo
; Johansson, Fredrik
LU
; Jirenhed, Dan-Anders
LU
and Hesslow, Germund
LU
(2015)
In Proceedings of the National Academy of Sciences
112(45).
p.14060-14065
- Abstract
- A central tenet of Rescorla and Wagner's model of associative learning is that the reinforcement value of a paired trial diminishes as the associative strength between the presented stimuli increases. Despite its fundamental importance to behavioral sciences, the neural mechanisms underlying the model have not been fully explored. Here, we present findings that, taken together, can explain why a stronger association leads to a reduced reinforcement value, within the context of eyeblink conditioning. Specifically, we show that learned pause responses in Purkinje cells, which trigger adaptively timed conditioned eyeblinks, suppress the unconditional stimulus (US) signal in a graded manner. Furthermore, by examining how Purkinje cells respond... (More)
- A central tenet of Rescorla and Wagner's model of associative learning is that the reinforcement value of a paired trial diminishes as the associative strength between the presented stimuli increases. Despite its fundamental importance to behavioral sciences, the neural mechanisms underlying the model have not been fully explored. Here, we present findings that, taken together, can explain why a stronger association leads to a reduced reinforcement value, within the context of eyeblink conditioning. Specifically, we show that learned pause responses in Purkinje cells, which trigger adaptively timed conditioned eyeblinks, suppress the unconditional stimulus (US) signal in a graded manner. Furthermore, by examining how Purkinje cells respond to two distinct conditional stimuli and to a compound stimulus, we provide evidence that could potentially help explain the somewhat counterintuitive overexpectation phenomenon, which was derived from the Rescorla-Wagner model. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8148258
- author
- Rasmussen, Anders
LU
; Zucca, Riccardo
; Johansson, Fredrik
LU
; Jirenhed, Dan-Anders
LU
and Hesslow, Germund
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Proceedings of the National Academy of Sciences
- volume
- 112
- issue
- 45
- pages
- 14060 - 14065
- publisher
- National Academy of Sciences
- external identifiers
-
- pmid:26504227
- wos:000364470300085
- scopus:84946763304
- pmid:26504227
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.1516986112
- project
- Thinking in Time: Cognition, Communication and Learning
- language
- English
- LU publication?
- yes
- id
- a5098ae9-87e2-466c-82dd-b5f159b711a2 (old id 8148258)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26504227?dopt=Abstract
- date added to LUP
- 2016-04-01 11:12:55
- date last changed
- 2022-05-16 12:08:51
@article{a5098ae9-87e2-466c-82dd-b5f159b711a2,
abstract = {{A central tenet of Rescorla and Wagner's model of associative learning is that the reinforcement value of a paired trial diminishes as the associative strength between the presented stimuli increases. Despite its fundamental importance to behavioral sciences, the neural mechanisms underlying the model have not been fully explored. Here, we present findings that, taken together, can explain why a stronger association leads to a reduced reinforcement value, within the context of eyeblink conditioning. Specifically, we show that learned pause responses in Purkinje cells, which trigger adaptively timed conditioned eyeblinks, suppress the unconditional stimulus (US) signal in a graded manner. Furthermore, by examining how Purkinje cells respond to two distinct conditional stimuli and to a compound stimulus, we provide evidence that could potentially help explain the somewhat counterintuitive overexpectation phenomenon, which was derived from the Rescorla-Wagner model.}},
author = {{Rasmussen, Anders and Zucca, Riccardo and Johansson, Fredrik and Jirenhed, Dan-Anders and Hesslow, Germund}},
issn = {{1091-6490}},
language = {{eng}},
number = {{45}},
pages = {{14060--14065}},
publisher = {{National Academy of Sciences}},
series = {{Proceedings of the National Academy of Sciences}},
title = {{Purkinje cell activity during classical conditioning with different conditional stimulus explains central tenet of Rescorla-Wagner model.}},
url = {{http://dx.doi.org/10.1073/pnas.1516986112}},
doi = {{10.1073/pnas.1516986112}},
volume = {{112}},
year = {{2015}},
}