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Purkinje cell activity during classical conditioning with different conditional stimulus explains central tenet of Rescorla-Wagner model.

Rasmussen, Anders LU ; Zucca, Riccardo; Johansson, Fredrik LU ; Jirenhed, Dan-Anders LU and Hesslow, Germund LU (2015) In Proceedings of the National Academy of Sciences 112(45). p.14060-14065
Abstract
A central tenet of Rescorla and Wagner's model of associative learning is that the reinforcement value of a paired trial diminishes as the associative strength between the presented stimuli increases. Despite its fundamental importance to behavioral sciences, the neural mechanisms underlying the model have not been fully explored. Here, we present findings that, taken together, can explain why a stronger association leads to a reduced reinforcement value, within the context of eyeblink conditioning. Specifically, we show that learned pause responses in Purkinje cells, which trigger adaptively timed conditioned eyeblinks, suppress the unconditional stimulus (US) signal in a graded manner. Furthermore, by examining how Purkinje cells respond... (More)
A central tenet of Rescorla and Wagner's model of associative learning is that the reinforcement value of a paired trial diminishes as the associative strength between the presented stimuli increases. Despite its fundamental importance to behavioral sciences, the neural mechanisms underlying the model have not been fully explored. Here, we present findings that, taken together, can explain why a stronger association leads to a reduced reinforcement value, within the context of eyeblink conditioning. Specifically, we show that learned pause responses in Purkinje cells, which trigger adaptively timed conditioned eyeblinks, suppress the unconditional stimulus (US) signal in a graded manner. Furthermore, by examining how Purkinje cells respond to two distinct conditional stimuli and to a compound stimulus, we provide evidence that could potentially help explain the somewhat counterintuitive overexpectation phenomenon, which was derived from the Rescorla-Wagner model. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Proceedings of the National Academy of Sciences
volume
112
issue
45
pages
14060 - 14065
publisher
National Acad Sciences
external identifiers
  • pmid:26504227
  • wos:000364470300085
  • scopus:84946763304
ISSN
1091-6490
DOI
10.1073/pnas.1516986112
project
Cognition, Communication and Learning
language
English
LU publication?
yes
id
a5098ae9-87e2-466c-82dd-b5f159b711a2 (old id 8148258)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26504227?dopt=Abstract
date added to LUP
2015-11-04 17:27:34
date last changed
2017-01-01 04:15:44
@article{a5098ae9-87e2-466c-82dd-b5f159b711a2,
  abstract     = {A central tenet of Rescorla and Wagner's model of associative learning is that the reinforcement value of a paired trial diminishes as the associative strength between the presented stimuli increases. Despite its fundamental importance to behavioral sciences, the neural mechanisms underlying the model have not been fully explored. Here, we present findings that, taken together, can explain why a stronger association leads to a reduced reinforcement value, within the context of eyeblink conditioning. Specifically, we show that learned pause responses in Purkinje cells, which trigger adaptively timed conditioned eyeblinks, suppress the unconditional stimulus (US) signal in a graded manner. Furthermore, by examining how Purkinje cells respond to two distinct conditional stimuli and to a compound stimulus, we provide evidence that could potentially help explain the somewhat counterintuitive overexpectation phenomenon, which was derived from the Rescorla-Wagner model.},
  author       = {Rasmussen, Anders and Zucca, Riccardo and Johansson, Fredrik and Jirenhed, Dan-Anders and Hesslow, Germund},
  issn         = {1091-6490},
  language     = {eng},
  number       = {45},
  pages        = {14060--14065},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Purkinje cell activity during classical conditioning with different conditional stimulus explains central tenet of Rescorla-Wagner model.},
  url          = {http://dx.doi.org/10.1073/pnas.1516986112},
  volume       = {112},
  year         = {2015},
}