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Maternal and child FADS genotype as determinants of cord blood long chain polyunsaturated fatty acid (LCPUFA) concentrations in the Seychelles Child Development Study

Conway, Marie C ; McSorley, Emeir M ; Mulhern, Maria S ; Spence, Toni ; Weslowska, Maria ; Strain, J J ; van Wijngaarden, Edwin ; Davidson, Phil W ; Myers, Gary J and Wahlberg, Karin E LU , et al. (2021) In British Journal of Nutrition 126(11). p.1687-1697
Abstract

Optimal maternal long chain polyunsaturated fatty acid (LCPUFA) status is essential for the developing foetus. The fatty acid desaturase (FADS) genes are involved in the endogenous synthesis of LCPUFA. The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and α-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). There is limited research on the influence of FADS genotype on cord PUFA status. The current study investigated the influence of maternal and child genetic variation in FADS genotype on cord blood PUFA status in a high fish-eating cohort. Cord blood samples... (More)

Optimal maternal long chain polyunsaturated fatty acid (LCPUFA) status is essential for the developing foetus. The fatty acid desaturase (FADS) genes are involved in the endogenous synthesis of LCPUFA. The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and α-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). There is limited research on the influence of FADS genotype on cord PUFA status. The current study investigated the influence of maternal and child genetic variation in FADS genotype on cord blood PUFA status in a high fish-eating cohort. Cord blood samples (n=1088) collected from the Seychelles Child Development Study (SCDS) Nutrition Cohort 2 (NC2) were analysed for total serum PUFA. Of those with cord PUFA data available, maternal (n=1062) and child (n=916), FADS1 (rs174537, rs174561), FADS2 (rs174575), and FADS1-FADS2 (rs3834458) were determined. Regression analysis determined that maternal minor allele homozygosity was associated with lower cord blood concentrations of docosahexaenoic acid (DHA) and the sum of EPA+DHA. Lower cord blood AA concentrations were observed in children who were minor allele homozygous for rs3834458 (β=0.075; p=0.037). Children who were minor allele carriers for rs174537, rs174561, rs174575 and rs3834458 had a lower cord blood AA:LA ratio (p<0.05 for all). Both maternal and child FADS genotype were associated with cord LCPUFA concentrations, and therefore, the influence of FADS genotype was observed despite the high intake of preformed dietary LCPUFA from fish in this population.

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type
Contribution to journal
publication status
published
subject
in
British Journal of Nutrition
volume
126
issue
11
pages
1687 - 1697
publisher
Cambridge University Press
external identifiers
  • scopus:85100490216
  • pmid:33526157
ISSN
1475-2662
DOI
10.1017/S0007114521000441
language
English
LU publication?
yes
id
a6695062-84fc-4e1f-9cef-bc47d461544d
date added to LUP
2021-02-04 13:20:50
date last changed
2022-08-04 07:12:03
@article{a6695062-84fc-4e1f-9cef-bc47d461544d,
  abstract     = {{<p>Optimal maternal long chain polyunsaturated fatty acid (LCPUFA) status is essential for the developing foetus. The fatty acid desaturase (FADS) genes are involved in the endogenous synthesis of LCPUFA. The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and α-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). There is limited research on the influence of FADS genotype on cord PUFA status. The current study investigated the influence of maternal and child genetic variation in FADS genotype on cord blood PUFA status in a high fish-eating cohort. Cord blood samples (n=1088) collected from the Seychelles Child Development Study (SCDS) Nutrition Cohort 2 (NC2) were analysed for total serum PUFA. Of those with cord PUFA data available, maternal (n=1062) and child (n=916), FADS1 (rs174537, rs174561), FADS2 (rs174575), and FADS1-FADS2 (rs3834458) were determined. Regression analysis determined that maternal minor allele homozygosity was associated with lower cord blood concentrations of docosahexaenoic acid (DHA) and the sum of EPA+DHA. Lower cord blood AA concentrations were observed in children who were minor allele homozygous for rs3834458 (β=0.075; p=0.037). Children who were minor allele carriers for rs174537, rs174561, rs174575 and rs3834458 had a lower cord blood AA:LA ratio (p&lt;0.05 for all). Both maternal and child FADS genotype were associated with cord LCPUFA concentrations, and therefore, the influence of FADS genotype was observed despite the high intake of preformed dietary LCPUFA from fish in this population.</p>}},
  author       = {{Conway, Marie C and McSorley, Emeir M and Mulhern, Maria S and Spence, Toni and Weslowska, Maria and Strain, J J and van Wijngaarden, Edwin and Davidson, Phil W and Myers, Gary J and Wahlberg, Karin E and Shamlaye, Conrad F and Cobice, Diego F and Hyland, Barry W and Pineda, Daniela and Broberg, Karin and Yeates, Alison J}},
  issn         = {{1475-2662}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{11}},
  pages        = {{1687--1697}},
  publisher    = {{Cambridge University Press}},
  series       = {{British Journal of Nutrition}},
  title        = {{Maternal and child FADS genotype as determinants of cord blood long chain polyunsaturated fatty acid (LCPUFA) concentrations in the Seychelles Child Development Study}},
  url          = {{http://dx.doi.org/10.1017/S0007114521000441}},
  doi          = {{10.1017/S0007114521000441}},
  volume       = {{126}},
  year         = {{2021}},
}