Associations of Red Cell Distribution Width With Coronary Artery Calcium in the General Population

Pan, Jingxue; Borné, Yan; Gonçalves, Isabel; Persson, Margaretha; Engström, Gunnar

Associations of Red Cell Distribution Width With Coronary Artery Calcium in the General Population

Mark

Pan, Jingxue ^LU ; Borné, Yan ^LU ; Gonçalves, Isabel ^LU

; Persson, Margaretha ^LU

and Engström, Gunnar ^LU (2022) In Angiology 73(5). p.445-452

Abstract: Red cell distribution width (RDW) is a measure of the variability of erythrocyte volumes. RDW has been associated with incidence of cardiovascular diseases. However, the underlying mechanisms for the increased cardiovascular risk are still unclear. This study aimed to examine associations of RDW and coronary atherosclerosis in the general population. Computed tomography was performed and RDW was measured in fresh blood from 5772 subjects (aged 50–64 years) from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Multinomial logistic regression was conducted to examine the associations between RDW and coronary artery calcium score (CACS). A total of 3902 (67.6%) individuals had low CACS (≤10), 18.6% had moderate CACS (>10 and ≤100)... (More); Red cell distribution width (RDW) is a measure of the variability of erythrocyte volumes. RDW has been associated with incidence of cardiovascular diseases. However, the underlying mechanisms for the increased cardiovascular risk are still unclear. This study aimed to examine associations of RDW and coronary atherosclerosis in the general population. Computed tomography was performed and RDW was measured in fresh blood from 5772 subjects (aged 50–64 years) from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Multinomial logistic regression was conducted to examine the associations between RDW and coronary artery calcium score (CACS). A total of 3902 (67.6%) individuals had low CACS (≤10), 18.6% had moderate CACS (>10 and ≤100) and 13.8% had high CACS (>100). The proportion with high CACS was 11.7%, 12.7%, 13.7% and 18.3%, respectively, in quartile 1–4 of RDW. After controlling for traditional risk factors, there were significant associations between RDW and high CACS: odds ratio = 1.51, 95% confidence interval: 1.18–1.94, and P =.001, for 4^th vs 1^st quartile of RDW. Elevated RDW is associated with coronary artery calcification in the middle-aged general population. RDW could be a reproducible and easily assessable biomarker of coronary calcification and cardiovascular risk.
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Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/a692238d-0337-4532-9e63-59c5ef8969ce

author

Pan, Jingxue ^LU ; Borné, Yan ^LU ; Gonçalves, Isabel ^LU

; Persson, Margaretha ^LU

and Engström, Gunnar ^LU

organization

publishing date

2022

type

Contribution to journal

publication status

published

subject

Cardiac and Cardiovascular Systems

keywords

atherosclerosis, coronary calcification, general population, red cell distribution width

in

Angiology

volume

73

issue

5

pages

445 - 452

publisher

SAGE Publications

external identifiers

scopus:85120938795
pmid:34814760

ISSN

0003-3197

DOI

10.1177/00033197211052124

language

English

LU publication?

yes

id

a692238d-0337-4532-9e63-59c5ef8969ce

date added to LUP

2022-02-01 17:14:15

date last changed

2024-06-17 03:52:49

@article{a692238d-0337-4532-9e63-59c5ef8969ce,
  abstract     = {{<p>Red cell distribution width (RDW) is a measure of the variability of erythrocyte volumes. RDW has been associated with incidence of cardiovascular diseases. However, the underlying mechanisms for the increased cardiovascular risk are still unclear. This study aimed to examine associations of RDW and coronary atherosclerosis in the general population. Computed tomography was performed and RDW was measured in fresh blood from 5772 subjects (aged 50–64 years) from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Multinomial logistic regression was conducted to examine the associations between RDW and coronary artery calcium score (CACS). A total of 3902 (67.6%) individuals had low CACS (≤10), 18.6% had moderate CACS (&gt;10 and ≤100) and 13.8% had high CACS (&gt;100). The proportion with high CACS was 11.7%, 12.7%, 13.7% and 18.3%, respectively, in quartile 1–4 of RDW. After controlling for traditional risk factors, there were significant associations between RDW and high CACS: odds ratio = 1.51, 95% confidence interval: 1.18–1.94, and P =.001, for 4<sup>th</sup> vs 1<sup>st</sup> quartile of RDW. Elevated RDW is associated with coronary artery calcification in the middle-aged general population. RDW could be a reproducible and easily assessable biomarker of coronary calcification and cardiovascular risk.</p>}},
  author       = {{Pan, Jingxue and Borné, Yan and Gonçalves, Isabel and Persson, Margaretha and Engström, Gunnar}},
  issn         = {{0003-3197}},
  keywords     = {{atherosclerosis; coronary calcification; general population; red cell distribution width}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{445--452}},
  publisher    = {{SAGE Publications}},
  series       = {{Angiology}},
  title        = {{Associations of Red Cell Distribution Width With Coronary Artery Calcium in the General Population}},
  url          = {{http://dx.doi.org/10.1177/00033197211052124}},
  doi          = {{10.1177/00033197211052124}},
  volume       = {{73}},
  year         = {{2022}},
}

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Associations of Red Cell Distribution Width With Coronary Artery Calcium in the General Population