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Ambient and indoor air pollution exposure and adverse birth outcomes in Adama, Ethiopia

Flanagan, Erin LU orcid ; Oudin, Anna LU ; Walles, John LU orcid ; Abera, Asmamaw ; Mattisson, Kristoffer LU orcid ; Isaxon, Christina LU and Malmqvist, Ebba LU orcid (2022) In Environment International 164.
Abstract

Air pollution poses a threat to human health, with pregnant women and their developing fetuses being particularly vulnerable. A high dual burden of ambient and indoor air pollution exposure has been identified in Ethiopia, but studies investigating their effects on adverse birth outcomes are currently lacking. This study explores the association between ambient air pollution (NOX and NO2) and indoor air pollution (cooking fuel type) and fetal and neonatal death in Adama, Ethiopia. A prospective cohort of mothers and their babies was used, into which pregnant women were recruited at their first antenatal visit (n = 2085) from November 2015 to February 2018. Previously developed land-use regression models were... (More)

Air pollution poses a threat to human health, with pregnant women and their developing fetuses being particularly vulnerable. A high dual burden of ambient and indoor air pollution exposure has been identified in Ethiopia, but studies investigating their effects on adverse birth outcomes are currently lacking. This study explores the association between ambient air pollution (NOX and NO2) and indoor air pollution (cooking fuel type) and fetal and neonatal death in Adama, Ethiopia. A prospective cohort of mothers and their babies was used, into which pregnant women were recruited at their first antenatal visit (n = 2085) from November 2015 to February 2018. Previously developed land-use regression models were utilized to assess ambient concentrations of NOX and NO2 at the residential address, whereas data on cooking fuel type was derived from questionnaires. Birth outcome data was obtained from self-reported questionnaire responses during the participant's postnatal visit or by phone if an in-person meeting was not possible. Binary logistic regression was employed to assess associations within the final study population (n = 1616) using both univariate and multivariate models; the latter of which adjusted for age, education, parity, and HIV status. Odds ratios (OR) and their corresponding 95% confidence intervals (CI) were reported. Within the cohort, 69 instances of fetal death (n = 16 miscarriages; n = 53 stillbirths) and 16 cases of neonatal death were identified. The findings suggest a tendency towards an association between ambient NOX and NO2 exposure during pregnancy and an increased risk of fetal death overall as well as stillbirth, specifically. However, statistical significance was not observed. Results for indoor air pollution and neonatal death were inconclusive. As limited evidence on the effects of exposure to ambient air pollution on adverse birth outcomes exists in Sub-Saharan Africa and Ethiopia, additional studies with larger study populations should be conducted.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ambient air pollution, Birth outcomes, Cooking fuel, Fetal death, Indoor air pollution, Neonatal death
in
Environment International
volume
164
article number
107251
publisher
Elsevier
external identifiers
  • scopus:85129707533
  • pmid:35533531
ISSN
0160-4120
DOI
10.1016/j.envint.2022.107251
language
English
LU publication?
yes
id
a73b0cef-0ce1-44ae-8965-b87696dbc310
date added to LUP
2022-12-28 14:04:20
date last changed
2024-06-15 01:10:45
@article{a73b0cef-0ce1-44ae-8965-b87696dbc310,
  abstract     = {{<p>Air pollution poses a threat to human health, with pregnant women and their developing fetuses being particularly vulnerable. A high dual burden of ambient and indoor air pollution exposure has been identified in Ethiopia, but studies investigating their effects on adverse birth outcomes are currently lacking. This study explores the association between ambient air pollution (NO<sub>X</sub> and NO<sub>2</sub>) and indoor air pollution (cooking fuel type) and fetal and neonatal death in Adama, Ethiopia. A prospective cohort of mothers and their babies was used, into which pregnant women were recruited at their first antenatal visit (n = 2085) from November 2015 to February 2018. Previously developed land-use regression models were utilized to assess ambient concentrations of NO<sub>X</sub> and NO<sub>2</sub> at the residential address, whereas data on cooking fuel type was derived from questionnaires. Birth outcome data was obtained from self-reported questionnaire responses during the participant's postnatal visit or by phone if an in-person meeting was not possible. Binary logistic regression was employed to assess associations within the final study population (n = 1616) using both univariate and multivariate models; the latter of which adjusted for age, education, parity, and HIV status. Odds ratios (OR) and their corresponding 95% confidence intervals (CI) were reported. Within the cohort, 69 instances of fetal death (n = 16 miscarriages; n = 53 stillbirths) and 16 cases of neonatal death were identified. The findings suggest a tendency towards an association between ambient NO<sub>X</sub> and NO<sub>2</sub> exposure during pregnancy and an increased risk of fetal death overall as well as stillbirth, specifically. However, statistical significance was not observed. Results for indoor air pollution and neonatal death were inconclusive. As limited evidence on the effects of exposure to ambient air pollution on adverse birth outcomes exists in Sub-Saharan Africa and Ethiopia, additional studies with larger study populations should be conducted.</p>}},
  author       = {{Flanagan, Erin and Oudin, Anna and Walles, John and Abera, Asmamaw and Mattisson, Kristoffer and Isaxon, Christina and Malmqvist, Ebba}},
  issn         = {{0160-4120}},
  keywords     = {{Ambient air pollution; Birth outcomes; Cooking fuel; Fetal death; Indoor air pollution; Neonatal death}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Environment International}},
  title        = {{Ambient and indoor air pollution exposure and adverse birth outcomes in Adama, Ethiopia}},
  url          = {{http://dx.doi.org/10.1016/j.envint.2022.107251}},
  doi          = {{10.1016/j.envint.2022.107251}},
  volume       = {{164}},
  year         = {{2022}},
}