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HIV-2 mediated effects on target and bystander cells induce plasma proteome remodeling

Johansson, Emil LU orcid ; Nazziwa, Jamirah LU orcid ; Freyhult, Eva ; Hong, Mun Gwan ; Lindman, Jacob LU ; Neptin, Malin LU ; Karlson, Sara LU orcid ; Rezeli, Melinda LU orcid ; Biague, Antonio J. and Medstrand, Patrik LU orcid , et al. (2024) In iScience 27(4).
Abstract

Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate the impact of viremic and aviremic HIV-2 infection on target and bystander cell pathology, we used data-independent acquisition mass spectrometry to determine plasma signatures of tissue and cell type engagement. Proteins derived from target and bystander cells in multiple tissues, such as the gastrointestinal tract and brain, were detected at elevated levels in plasma of PLWH2, compared with HIV negative controls. Moreover, viremic HIV-2 infection... (More)

Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate the impact of viremic and aviremic HIV-2 infection on target and bystander cell pathology, we used data-independent acquisition mass spectrometry to determine plasma signatures of tissue and cell type engagement. Proteins derived from target and bystander cells in multiple tissues, such as the gastrointestinal tract and brain, were detected at elevated levels in plasma of PLWH2, compared with HIV negative controls. Moreover, viremic HIV-2 infection appeared to induce enhanced release of proteins from a broader range of tissues compared to aviremic HIV-2 infection. This study expands the knowledge on the link between plasma proteome remodeling and the pathological cell engagement in tissues during HIV-2 infection.

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type
Contribution to journal
publication status
published
subject
keywords
Disease, Human specimen, Proteomics, Virology
in
iScience
volume
27
issue
4
article number
109344
publisher
Elsevier
external identifiers
  • pmid:38500818
  • scopus:85187572828
ISSN
2589-0042
DOI
10.1016/j.isci.2024.109344
language
English
LU publication?
yes
id
a8aa1bc0-3c3f-48e3-8aae-1e37b9ed849b
date added to LUP
2024-03-27 14:59:43
date last changed
2024-04-24 19:01:18
@article{a8aa1bc0-3c3f-48e3-8aae-1e37b9ed849b,
  abstract     = {{<p>Despite low or undetectable plasma viral load, people living with HIV-2 (PLWH2) typically progress toward AIDS. The driving forces behind HIV-2 disease progression and the role of viremia are still not known, but low-level replication in tissues is believed to play a role. To investigate the impact of viremic and aviremic HIV-2 infection on target and bystander cell pathology, we used data-independent acquisition mass spectrometry to determine plasma signatures of tissue and cell type engagement. Proteins derived from target and bystander cells in multiple tissues, such as the gastrointestinal tract and brain, were detected at elevated levels in plasma of PLWH2, compared with HIV negative controls. Moreover, viremic HIV-2 infection appeared to induce enhanced release of proteins from a broader range of tissues compared to aviremic HIV-2 infection. This study expands the knowledge on the link between plasma proteome remodeling and the pathological cell engagement in tissues during HIV-2 infection.</p>}},
  author       = {{Johansson, Emil and Nazziwa, Jamirah and Freyhult, Eva and Hong, Mun Gwan and Lindman, Jacob and Neptin, Malin and Karlson, Sara and Rezeli, Melinda and Biague, Antonio J. and Medstrand, Patrik and Månsson, Fredrik and Norrgren, Hans and Esbjörnsson, Joakim and Jansson, Marianne}},
  issn         = {{2589-0042}},
  keywords     = {{Disease; Human specimen; Proteomics; Virology}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{4}},
  publisher    = {{Elsevier}},
  series       = {{iScience}},
  title        = {{HIV-2 mediated effects on target and bystander cells induce plasma proteome remodeling}},
  url          = {{http://dx.doi.org/10.1016/j.isci.2024.109344}},
  doi          = {{10.1016/j.isci.2024.109344}},
  volume       = {{27}},
  year         = {{2024}},
}