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Motility index measured by magnetic resonance enterography is associated with sex and mural thickness

Månsson, Sven LU orcid ; Ekberg, Olle LU and Ohlsson, Bodil LU (2020) In World Journal of Gastroenterology 26(36). p.5484-5497
Abstract

BACKGROUND Recently, a technique has been developed to use magnetic resonance enterography (MRE) for the evaluation of small bowel motility. The hypothesis was that assessment of the motility index (MI) should reflect differences in motility between clinical conditions. AIM To aim of the present observational, cross-sectional study was to evaluate the use of the MI in daily clinical practice. METHODS All consecutive patients aged 18-70 years who were referred for MRE at the Department of Radiology during a 2-year period were asked to participate. Healthy volunteers were included as controls. MRE was prepared and conducted in accordance with clinical routines. On the day of examination, all the participants had to complete the visual... (More)

BACKGROUND Recently, a technique has been developed to use magnetic resonance enterography (MRE) for the evaluation of small bowel motility. The hypothesis was that assessment of the motility index (MI) should reflect differences in motility between clinical conditions. AIM To aim of the present observational, cross-sectional study was to evaluate the use of the MI in daily clinical practice. METHODS All consecutive patients aged 18-70 years who were referred for MRE at the Department of Radiology during a 2-year period were asked to participate. Healthy volunteers were included as controls. MRE was prepared and conducted in accordance with clinical routines. On the day of examination, all the participants had to complete the visual analog scale for irritable bowel syndrome (IBS) and IBS-symptom severity scale. Maps of MI were calculated from dynamic MR images. ANOVA was used to evaluate differences in MI between groups, classified as healthy, Crohn's disease, ulcerative colitis, IBS, other assorted disorders and dysmotility. Logistic and linear regression were applied to the MI values. All medical records were scrutinized for medical history. RESULTS In all, 224 examinations were included (inclusion prevalence 76.3%), with 22 controls and 202 patients. There was a significant difference in the MI of the jejunum (P = 0.021) and terminal ileum (P = 0.007) between the different groups. The MI was inversely associated with the mural thickness of the terminal ileum in men (P < 0.001) and women (P = 0.063) after adjustments, and tended to be lower in men than in women (P = 0.056). Subjectively observed reduction of motility on MRI was accomplished by reduced MI of terminal ileum in men (P < 0.001) and women (P = 0.030). In women, diarrhea was inversely associated with the MI of the jejunum (P = 0.029), and constipation was positively associated with the MI of the terminal ileum (P = 0.039). CONCLUSION Although MIs differ across diseases, a lower MI of the terminal ileum is mainly associated with male sex and an increased mural thickness. Symptoms are weakly associated with the MI.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dysmotility, Gastrointestinal symptoms, Magnetic resonance enterography, Motility index, Mural thickness, Small bowel
in
World Journal of Gastroenterology
volume
26
issue
36
pages
14 pages
publisher
WJG Press
external identifiers
  • pmid:33024399
  • scopus:85092647397
ISSN
1007-9327
DOI
10.3748/wjg.v26.i36.5484
language
English
LU publication?
yes
id
a9b4179b-57bc-4620-8d9f-855f7a119a1c
date added to LUP
2020-11-10 08:01:57
date last changed
2024-04-03 17:17:53
@article{a9b4179b-57bc-4620-8d9f-855f7a119a1c,
  abstract     = {{<p>BACKGROUND Recently, a technique has been developed to use magnetic resonance enterography (MRE) for the evaluation of small bowel motility. The hypothesis was that assessment of the motility index (MI) should reflect differences in motility between clinical conditions. AIM To aim of the present observational, cross-sectional study was to evaluate the use of the MI in daily clinical practice. METHODS All consecutive patients aged 18-70 years who were referred for MRE at the Department of Radiology during a 2-year period were asked to participate. Healthy volunteers were included as controls. MRE was prepared and conducted in accordance with clinical routines. On the day of examination, all the participants had to complete the visual analog scale for irritable bowel syndrome (IBS) and IBS-symptom severity scale. Maps of MI were calculated from dynamic MR images. ANOVA was used to evaluate differences in MI between groups, classified as healthy, Crohn's disease, ulcerative colitis, IBS, other assorted disorders and dysmotility. Logistic and linear regression were applied to the MI values. All medical records were scrutinized for medical history. RESULTS In all, 224 examinations were included (inclusion prevalence 76.3%), with 22 controls and 202 patients. There was a significant difference in the MI of the jejunum (P = 0.021) and terminal ileum (P = 0.007) between the different groups. The MI was inversely associated with the mural thickness of the terminal ileum in men (P &lt; 0.001) and women (P = 0.063) after adjustments, and tended to be lower in men than in women (P = 0.056). Subjectively observed reduction of motility on MRI was accomplished by reduced MI of terminal ileum in men (P &lt; 0.001) and women (P = 0.030). In women, diarrhea was inversely associated with the MI of the jejunum (P = 0.029), and constipation was positively associated with the MI of the terminal ileum (P = 0.039). CONCLUSION Although MIs differ across diseases, a lower MI of the terminal ileum is mainly associated with male sex and an increased mural thickness. Symptoms are weakly associated with the MI. </p>}},
  author       = {{Månsson, Sven and Ekberg, Olle and Ohlsson, Bodil}},
  issn         = {{1007-9327}},
  keywords     = {{Dysmotility; Gastrointestinal symptoms; Magnetic resonance enterography; Motility index; Mural thickness; Small bowel}},
  language     = {{eng}},
  number       = {{36}},
  pages        = {{5484--5497}},
  publisher    = {{WJG Press}},
  series       = {{World Journal of Gastroenterology}},
  title        = {{Motility index measured by magnetic resonance enterography is associated with sex and mural thickness}},
  url          = {{http://dx.doi.org/10.3748/wjg.v26.i36.5484}},
  doi          = {{10.3748/wjg.v26.i36.5484}},
  volume       = {{26}},
  year         = {{2020}},
}