Causal analysis of plasma IL-8 on carotid intima media thickness, a measure of subclinical atherosclerosis
(2023) In Current Research in Translational Medicine 71(1).- Abstract
BACKGROUND: We investigated the causality of IL-8 on carotid intima-media thickness (c-IMT), a measure of sub-clinical atherosclerosis.
METHODS: The IMPROVE is a multicenter European study (n = 3,711). The association of plasma IL-8 with c-IMT (mm) was estimated by quantile regression. Genotyping was performed using the Illumina CardioMetabo and Immuno chips. Replication was attempted in three independent studies and a meta-analysis was performed using a random model.
RESULTS: In IMPROVE, each unit increase in plasma IL-8 was associated with an increase in median c-IMT measures (all p<0·03) in multivariable analyses. Linear regression identified rs117518778 and rs8057084 as associated with IL-8 levels and with measures of... (More)
BACKGROUND: We investigated the causality of IL-8 on carotid intima-media thickness (c-IMT), a measure of sub-clinical atherosclerosis.
METHODS: The IMPROVE is a multicenter European study (n = 3,711). The association of plasma IL-8 with c-IMT (mm) was estimated by quantile regression. Genotyping was performed using the Illumina CardioMetabo and Immuno chips. Replication was attempted in three independent studies and a meta-analysis was performed using a random model.
RESULTS: In IMPROVE, each unit increase in plasma IL-8 was associated with an increase in median c-IMT measures (all p<0·03) in multivariable analyses. Linear regression identified rs117518778 and rs8057084 as associated with IL-8 levels and with measures of c-IMT. The two SNPs were combined in an IL-8-increasing genetic risk that showed causality of IL-8 on c-IMT in IMPROVE and in the UK Biobank (n = 22,179). The effect of IL-8 on c-IMT measures was confirmed in PIVUS (n = 1,016) and MDCCC (n = 6,103). The association of rs8057084 with c-IMT was confirmed in PIVUS and UK Biobank with a pooled estimate effect (β) of -0·006 with 95%CI (-0·008- -0·003).
CONCLUSION: Our results indicate that genetic variants associated with plasma IL-8 also associate with c-IMT. However, we cannot infer causality of this association, as these variants lie outside of the IL8 locus.
(Less)
- author
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Research in Translational Medicine
- volume
- 71
- issue
- 1
- article number
- 103374
- publisher
- Elsevier
- external identifiers
-
- pmid:36493747
- scopus:85143883824
- ISSN
- 2452-3186
- DOI
- 10.1016/j.retram.2022.103374
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2022 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.
- id
- aa96e9d7-dfc6-4e19-acc3-d423fa36fafc
- date added to LUP
- 2022-12-16 14:00:00
- date last changed
- 2024-09-22 09:23:54
@article{aa96e9d7-dfc6-4e19-acc3-d423fa36fafc, abstract = {{<p>BACKGROUND: We investigated the causality of IL-8 on carotid intima-media thickness (c-IMT), a measure of sub-clinical atherosclerosis.</p><p>METHODS: The IMPROVE is a multicenter European study (n = 3,711). The association of plasma IL-8 with c-IMT (mm) was estimated by quantile regression. Genotyping was performed using the Illumina CardioMetabo and Immuno chips. Replication was attempted in three independent studies and a meta-analysis was performed using a random model.</p><p>RESULTS: In IMPROVE, each unit increase in plasma IL-8 was associated with an increase in median c-IMT measures (all p<0·03) in multivariable analyses. Linear regression identified rs117518778 and rs8057084 as associated with IL-8 levels and with measures of c-IMT. The two SNPs were combined in an IL-8-increasing genetic risk that showed causality of IL-8 on c-IMT in IMPROVE and in the UK Biobank (n = 22,179). The effect of IL-8 on c-IMT measures was confirmed in PIVUS (n = 1,016) and MDCCC (n = 6,103). The association of rs8057084 with c-IMT was confirmed in PIVUS and UK Biobank with a pooled estimate effect (β) of -0·006 with 95%CI (-0·008- -0·003).</p><p>CONCLUSION: Our results indicate that genetic variants associated with plasma IL-8 also associate with c-IMT. However, we cannot infer causality of this association, as these variants lie outside of the IL8 locus.</p>}}, author = {{Velásquez, Ilais Moreno and Malarstig, Anders and Baldassarre, Damiano and Borne, Yan and de Faire, Ulf and Engström, Gunnar and Eriksson, Per and Giral, Philippe and Humphries, Steve E and Kurl, Sudhir and Leander, Karin and Lind, Lars and Lindén, Anders and Orsini, Nicola and Pirro, Matteo and Silveira, Angela and Smit, Andries J and Tremoli, Elena and Veglia, Fabrizio and Strawbridge, Rona J and Gigante, Bruna}}, issn = {{2452-3186}}, language = {{eng}}, number = {{1}}, publisher = {{Elsevier}}, series = {{Current Research in Translational Medicine}}, title = {{Causal analysis of plasma IL-8 on carotid intima media thickness, a measure of subclinical atherosclerosis}}, url = {{http://dx.doi.org/10.1016/j.retram.2022.103374}}, doi = {{10.1016/j.retram.2022.103374}}, volume = {{71}}, year = {{2023}}, }