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Delayed Clinical Manifestation of Parkinson's Disease among Physically Active : Do Participants in a Long-Distance Ski Race Have a Motor Reserve?

Olsson, Tomas T. LU ; Svensson, Martina LU orcid ; Hållmarker, Ulf ; James, Stefan and Deierborg, Tomas LU (2020) In Journal of Parkinson's Disease 10(1). p.267-274
Abstract

Background: Physical activity is associated with reduced risk of Parkinson's disease (PD). The explanations for this association are not completely elucidated. We use long-term PD-incidence data from long-distance skiers to study the relationship between exercise and PD. Objective: We aimed to investigate if physical activity is associated with long-term lower risk of PD and if this association could be explained by physically active people being able to sustain more PD neuropathology before clinical symptoms, a motor reserve. Methods: Using a prospective observational design, we studied whether long-distance skiers of the Swedish Vasaloppet (n = 197,685), exhibited reduced incidence of PD compared to matched individuals from the... (More)

Background: Physical activity is associated with reduced risk of Parkinson's disease (PD). The explanations for this association are not completely elucidated. We use long-term PD-incidence data from long-distance skiers to study the relationship between exercise and PD. Objective: We aimed to investigate if physical activity is associated with long-term lower risk of PD and if this association could be explained by physically active people being able to sustain more PD neuropathology before clinical symptoms, a motor reserve. Methods: Using a prospective observational design, we studied whether long-distance skiers of the Swedish Vasaloppet (n = 197,685), exhibited reduced incidence of PD compared to matched individuals from the general population (n = 197,684) during 21 years of follow-up (median 10, interquartile range (IQR) 5-15 years). Results: Vasaloppet skiers (median age 36.0 years [IQR 29.0-46.0], 38% women) had lower incidence of PD (HR: 0.71; 95 % CI 0.56-0.90) compared to non-skiers. When reducing risk for reverse causation by excluding PD cases within the first five years from race participation, there was still a trend for lower risk of PD (HR: 0.80; 95 % CI 0.62-1.03). Further, the PD prevalence converged between skiers and non-skiers after 15 years of follow-up, which is more consistent with a motor reserve in the physically active rather than neuroprotection. Conclusions: A physical active lifestyle is associated with reduced risk for PD. This association weakens with time and might be explained by a motor reserve among the physically active.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
exercise, motor reserve, Parkinson's disease, Physical activity
in
Journal of Parkinson's Disease
volume
10
issue
1
pages
8 pages
publisher
IOS Press
external identifiers
  • pmid:31609700
  • scopus:85078492890
ISSN
1877-7171
DOI
10.3233/JPD-191762
language
English
LU publication?
yes
id
aae37748-d5b6-4427-aaf6-c46f84d06404
date added to LUP
2020-02-10 12:58:34
date last changed
2025-01-10 06:31:17
@article{aae37748-d5b6-4427-aaf6-c46f84d06404,
  abstract     = {{<p>Background: Physical activity is associated with reduced risk of Parkinson's disease (PD). The explanations for this association are not completely elucidated. We use long-term PD-incidence data from long-distance skiers to study the relationship between exercise and PD. Objective: We aimed to investigate if physical activity is associated with long-term lower risk of PD and if this association could be explained by physically active people being able to sustain more PD neuropathology before clinical symptoms, a motor reserve. Methods: Using a prospective observational design, we studied whether long-distance skiers of the Swedish Vasaloppet (n = 197,685), exhibited reduced incidence of PD compared to matched individuals from the general population (n = 197,684) during 21 years of follow-up (median 10, interquartile range (IQR) 5-15 years). Results: Vasaloppet skiers (median age 36.0 years [IQR 29.0-46.0], 38% women) had lower incidence of PD (HR: 0.71; 95 % CI 0.56-0.90) compared to non-skiers. When reducing risk for reverse causation by excluding PD cases within the first five years from race participation, there was still a trend for lower risk of PD (HR: 0.80; 95 % CI 0.62-1.03). Further, the PD prevalence converged between skiers and non-skiers after 15 years of follow-up, which is more consistent with a motor reserve in the physically active rather than neuroprotection. Conclusions: A physical active lifestyle is associated with reduced risk for PD. This association weakens with time and might be explained by a motor reserve among the physically active.</p>}},
  author       = {{Olsson, Tomas T. and Svensson, Martina and Hållmarker, Ulf and James, Stefan and Deierborg, Tomas}},
  issn         = {{1877-7171}},
  keywords     = {{exercise; motor reserve; Parkinson's disease; Physical activity}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{267--274}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Parkinson's Disease}},
  title        = {{Delayed Clinical Manifestation of Parkinson's Disease among Physically Active : Do Participants in a Long-Distance Ski Race Have a Motor Reserve?}},
  url          = {{http://dx.doi.org/10.3233/JPD-191762}},
  doi          = {{10.3233/JPD-191762}},
  volume       = {{10}},
  year         = {{2020}},
}