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Abnormal cell cycle regulation in malignancy

Dictor, Michael LU ; Ehinger, Mats LU ; Mertens, Fredrik LU ; Åkervall, Jan LU and Wennerberg, Johan LU orcid (1999) In American Journal of Clinical Pathology 112(1 Suppl 1). p.40-52
Abstract

The cell cycle consists of an initial growth phase (G1), DNA replication (S), a gap phase (G2), and mitosis (M), after which the cell may differentiate or enter the resting state (G0). The cycle is driven by a number of positive and negative regulatory phosphorylation and dephosphorylation events, involving protein kinases, protein phosphatases, cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors, that ultimately impinge on the activity of transcription factors. Unreplicated or damaged DNA blocks the progression of the cell cycle at checkpoints, including a late G1 checkpoint regulated by the dephosphorylated retinoblastoma protein and a late G2 checkpoint regulated by the phosphorylation of cyclin-dependent kinase... (More)

The cell cycle consists of an initial growth phase (G1), DNA replication (S), a gap phase (G2), and mitosis (M), after which the cell may differentiate or enter the resting state (G0). The cycle is driven by a number of positive and negative regulatory phosphorylation and dephosphorylation events, involving protein kinases, protein phosphatases, cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors, that ultimately impinge on the activity of transcription factors. Unreplicated or damaged DNA blocks the progression of the cell cycle at checkpoints, including a late G1 checkpoint regulated by the dephosphorylated retinoblastoma protein and a late G2 checkpoint regulated by the phosphorylation of cyclin-dependent kinase 1 complexed with cyclin B. Many cell cycle regulator genes may be considered proto-oncogenes or tumor suppressor genes, and point mutations, amplifications, deletions, or rearrangements involving their loci, particularly those in the "RB pathway," are associated with various tumors. A number of molecular techniques may be used to detect genomic alterations or posttranscriptional modifications, but immunohistochemistry remains the most common method to determine expression levels of a regulatory protein. Multivariate analysis of the usefulness in prognosis has been applied most often for the general proliferation antigen Ki-67.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Tumor/genetics, Cell Cycle, Cell Cycle Proteins/genetics, Cost-Benefit Analysis, DNA, Neoplasm/analysis, Genetic Techniques/economics, Humans, Neoplasms/metabolism
in
American Journal of Clinical Pathology
volume
112
issue
1 Suppl 1
pages
13 pages
publisher
Oxford University Press
external identifiers
  • pmid:10396300
  • scopus:0033506770
ISSN
0002-9173
language
English
LU publication?
yes
id
ab8d7b61-f00b-4711-a84a-ba5d2c13f09f
date added to LUP
2022-01-23 15:32:03
date last changed
2024-04-20 20:09:41
@article{ab8d7b61-f00b-4711-a84a-ba5d2c13f09f,
  abstract     = {{<p>The cell cycle consists of an initial growth phase (G1), DNA replication (S), a gap phase (G2), and mitosis (M), after which the cell may differentiate or enter the resting state (G0). The cycle is driven by a number of positive and negative regulatory phosphorylation and dephosphorylation events, involving protein kinases, protein phosphatases, cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors, that ultimately impinge on the activity of transcription factors. Unreplicated or damaged DNA blocks the progression of the cell cycle at checkpoints, including a late G1 checkpoint regulated by the dephosphorylated retinoblastoma protein and a late G2 checkpoint regulated by the phosphorylation of cyclin-dependent kinase 1 complexed with cyclin B. Many cell cycle regulator genes may be considered proto-oncogenes or tumor suppressor genes, and point mutations, amplifications, deletions, or rearrangements involving their loci, particularly those in the "RB pathway," are associated with various tumors. A number of molecular techniques may be used to detect genomic alterations or posttranscriptional modifications, but immunohistochemistry remains the most common method to determine expression levels of a regulatory protein. Multivariate analysis of the usefulness in prognosis has been applied most often for the general proliferation antigen Ki-67.</p>}},
  author       = {{Dictor, Michael and Ehinger, Mats and Mertens, Fredrik and Åkervall, Jan and Wennerberg, Johan}},
  issn         = {{0002-9173}},
  keywords     = {{Biomarkers, Tumor/genetics; Cell Cycle; Cell Cycle Proteins/genetics; Cost-Benefit Analysis; DNA, Neoplasm/analysis; Genetic Techniques/economics; Humans; Neoplasms/metabolism}},
  language     = {{eng}},
  number       = {{1 Suppl 1}},
  pages        = {{40--52}},
  publisher    = {{Oxford University Press}},
  series       = {{American Journal of Clinical Pathology}},
  title        = {{Abnormal cell cycle regulation in malignancy}},
  volume       = {{112}},
  year         = {{1999}},
}