Dissociated incretin hormone response to protein versus fat ingestion in obese subjects.
(2011) In Diabetes, Obesity and Metabolism 13. p.863-865- Abstract
- Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers (BMI >30kg/m(2) ; n=12) and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat vs. protein. However, the total 300 min GIP response was greater after fat than after protein ingestion (20.3±3.9 vs. 10.0±2.8 nmol/l x 300 min; P=0.026), whereas the 300 min GLP-1 responses were the same. Thus, in... (More)
- Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers (BMI >30kg/m(2) ; n=12) and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat vs. protein. However, the total 300 min GIP response was greater after fat than after protein ingestion (20.3±3.9 vs. 10.0±2.8 nmol/l x 300 min; P=0.026), whereas the 300 min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300 min GIP secretion is more pronounced after fat than protein ingestion. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1973052
- author
- Lindgren, Ola LU ; Carr, R ; Holst, J J ; Deacon, C and Ahrén, Bo LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes, Obesity and Metabolism
- volume
- 13
- pages
- 863 - 865
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000293179200012
- pmid:21554523
- scopus:79960823117
- pmid:21554523
- ISSN
- 1462-8902
- DOI
- 10.1111/j.1463-1326.2011.01420.x
- language
- English
- LU publication?
- yes
- id
- ac1c843c-dfc5-47f5-a001-d2f082dc09f3 (old id 1973052)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21554523?dopt=Abstract
- date added to LUP
- 2016-04-04 08:56:43
- date last changed
- 2024-01-12 08:13:50
@article{ac1c843c-dfc5-47f5-a001-d2f082dc09f3,
abstract = {{Protein elicits a stronger early (30 min) glucose-dependent insulinotropic polypeptide (GIP) response than fat ingestion in lean individuals, with no difference in glucagon-like peptide-1 (GLP-1). We assessed the incretin hormone response to protein versus fat ingestion in obesity. Equicaloric (8 kcal/kg) fat (olive oil) or protein (whey protein) was ingested by non-diabetic obese male volunteers (BMI >30kg/m(2) ; n=12) and plasma GIP and GLP-1 were determined. We found no difference in the early GIP or GLP-1 responses to fat vs. protein. However, the total 300 min GIP response was greater after fat than after protein ingestion (20.3±3.9 vs. 10.0±2.8 nmol/l x 300 min; P=0.026), whereas the 300 min GLP-1 responses were the same. Thus, in obesity, protein and fat ingestion elicit similar early (30 min) incretin hormone responses, whereas 300 min GIP secretion is more pronounced after fat than protein ingestion.}},
author = {{Lindgren, Ola and Carr, R and Holst, J J and Deacon, C and Ahrén, Bo}},
issn = {{1462-8902}},
language = {{eng}},
pages = {{863--865}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetes, Obesity and Metabolism}},
title = {{Dissociated incretin hormone response to protein versus fat ingestion in obese subjects.}},
url = {{http://dx.doi.org/10.1111/j.1463-1326.2011.01420.x}},
doi = {{10.1111/j.1463-1326.2011.01420.x}},
volume = {{13}},
year = {{2011}},
}