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Head to head comparisons of two modalities of perfusion adenosine stress echocardiography with simultaneous SPECT

Gudmundsson, Petri ; Shahgaldi, Kambiz ; Winter, Reidar ; Dencker, Magnus LU ; Kitlinski, Mariusz LU ; Thorsson, Ola LU ; Ljunggren, Lennart and Willenheimer, Ronnie LU (2009) In Cardiovascular Ultrasound 7.
Abstract
Background: Real-time perfusion (RTP) contrast echocardiography can be used during adenosine stress echocardiography (ASE) to evaluate myocardial ischemia. We compared two different types of RTP power modulation techniques, angiomode (AM) and high-resolution grayscale (HR), with Tc-99m-tetrofosmin single-photon emission computed tomography (SPECT) for the detection of myocardial ischemia. Methods: Patients with known or suspected coronary artery disease (CAD), admitted to SPECT, were prospectively invited to participate. Patients underwent RTP imaging (SONOS 5500) using AM and HR during Sonovue (R) infusion, before and throughout the adenosine stress, also used for SPECT. Analysis of myocardial perfusion and wall motion by RTP-ASE were... (More)
Background: Real-time perfusion (RTP) contrast echocardiography can be used during adenosine stress echocardiography (ASE) to evaluate myocardial ischemia. We compared two different types of RTP power modulation techniques, angiomode (AM) and high-resolution grayscale (HR), with Tc-99m-tetrofosmin single-photon emission computed tomography (SPECT) for the detection of myocardial ischemia. Methods: Patients with known or suspected coronary artery disease (CAD), admitted to SPECT, were prospectively invited to participate. Patients underwent RTP imaging (SONOS 5500) using AM and HR during Sonovue (R) infusion, before and throughout the adenosine stress, also used for SPECT. Analysis of myocardial perfusion and wall motion by RTP-ASE were done for AM and HR at different time points, blinded to one another and to SPECT. Each segment was attributed to one of the three main coronary vessel areas of interest. Results: In 50 patients, 150 coronary areas were analyzed by SPECT and RTP-ASE AM and HR. SPECT showed evidence of ischemia in 13 out of 50 patients. There was no significant difference between AM and HR in detecting ischemia (p = 0.08). The agreement for AM and HR, compared to SPECT, was 93% and 96%, with Kappa values of 0.67 and 0.75, respectively (p < 0.001). Conclusion: There was no significant difference between AM and HR in correctly detecting myocardial ischemia as judged by SPECT. This suggests that different types of RTP modalities give comparable data during RTP-ASE in patients with known or suspected CAD. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cardiovascular Ultrasound
volume
7
article number
19
publisher
BioMed Central (BMC)
external identifiers
  • wos:000266625900002
  • scopus:65549118361
  • pmid:19379491
ISSN
1476-7120
DOI
10.1186/1476-7120-7-19
language
English
LU publication?
yes
id
ad44df86-6814-4105-84a4-a4f7220c78bf (old id 1444040)
date added to LUP
2016-04-01 14:27:54
date last changed
2025-04-04 14:51:03
@article{ad44df86-6814-4105-84a4-a4f7220c78bf,
  abstract     = {{Background: Real-time perfusion (RTP) contrast echocardiography can be used during adenosine stress echocardiography (ASE) to evaluate myocardial ischemia. We compared two different types of RTP power modulation techniques, angiomode (AM) and high-resolution grayscale (HR), with Tc-99m-tetrofosmin single-photon emission computed tomography (SPECT) for the detection of myocardial ischemia. Methods: Patients with known or suspected coronary artery disease (CAD), admitted to SPECT, were prospectively invited to participate. Patients underwent RTP imaging (SONOS 5500) using AM and HR during Sonovue (R) infusion, before and throughout the adenosine stress, also used for SPECT. Analysis of myocardial perfusion and wall motion by RTP-ASE were done for AM and HR at different time points, blinded to one another and to SPECT. Each segment was attributed to one of the three main coronary vessel areas of interest. Results: In 50 patients, 150 coronary areas were analyzed by SPECT and RTP-ASE AM and HR. SPECT showed evidence of ischemia in 13 out of 50 patients. There was no significant difference between AM and HR in detecting ischemia (p = 0.08). The agreement for AM and HR, compared to SPECT, was 93% and 96%, with Kappa values of 0.67 and 0.75, respectively (p &lt; 0.001). Conclusion: There was no significant difference between AM and HR in correctly detecting myocardial ischemia as judged by SPECT. This suggests that different types of RTP modalities give comparable data during RTP-ASE in patients with known or suspected CAD.}},
  author       = {{Gudmundsson, Petri and Shahgaldi, Kambiz and Winter, Reidar and Dencker, Magnus and Kitlinski, Mariusz and Thorsson, Ola and Ljunggren, Lennart and Willenheimer, Ronnie}},
  issn         = {{1476-7120}},
  language     = {{eng}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Cardiovascular Ultrasound}},
  title        = {{Head to head comparisons of two modalities of perfusion adenosine stress echocardiography with simultaneous SPECT}},
  url          = {{http://dx.doi.org/10.1186/1476-7120-7-19}},
  doi          = {{10.1186/1476-7120-7-19}},
  volume       = {{7}},
  year         = {{2009}},
}