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Alteration of putaminal fractional anisotropy in Parkinson’s disease : a longitudinal diffusion kurtosis imaging study

Surova, Yulia LU ; Nilsson, Markus LU ; Lampinen, Björn LU ; Lätt, Jimmy LU ; Hall, Sara LU ; Widner, Håkan LU ; van Westen, Danielle LU and Hansson, Oskar LU (2018) In Neuroradiology 60(3). p.247-254
Abstract

Purpose: In Parkinson’s disease (PD), pathological microstructural changes occur that may be detected using diffusion magnetic resonance imaging (dMRI). However, there are few longitudinal studies that explore the effect of disease progression on diffusion indices. Methods: We prospectively included 76 patients with PD and 38 healthy controls (HC), all of whom underwent diffusion kurtosis imaging (DKI) as part of the prospective Swedish BioFINDER study at baseline and 2 years later. Annualized rates of change in DKI parameters, including fractional anisotropy (FA), mean diffusivity (MD), and mean kurtosis (MK), were estimated in the gray matter (GM) by placing regions of interest (ROIs) in the basal ganglia and the thalamus, and in the... (More)

Purpose: In Parkinson’s disease (PD), pathological microstructural changes occur that may be detected using diffusion magnetic resonance imaging (dMRI). However, there are few longitudinal studies that explore the effect of disease progression on diffusion indices. Methods: We prospectively included 76 patients with PD and 38 healthy controls (HC), all of whom underwent diffusion kurtosis imaging (DKI) as part of the prospective Swedish BioFINDER study at baseline and 2 years later. Annualized rates of change in DKI parameters, including fractional anisotropy (FA), mean diffusivity (MD), and mean kurtosis (MK), were estimated in the gray matter (GM) by placing regions of interest (ROIs) in the basal ganglia and the thalamus, and in the white matter (WM) by tract-based spatial statistics (TBSS) analysis. Results: When adjusting for potential confounding factors (age, gender, baseline-follow-up interval, and software upgrade of MRI scanner), only a decrease in FA in the putamen of PD patients (β = − 0.248, P < .01) over 2 years was significantly different from the changes observed in HC over the same time period. This 2-year decrease in FA in the putamen in PD correlated with higher l-dopa equivalent dose at baseline (Spearman’s rho = .399, P < .0001). Conclusion: The study indicates that in PD microstructural changes in the putamen occur selectively over a 2-year period and can be detected with DKI.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diffusion kurtosis imaging, Parkinson’s disease, Tract-based spatial statistics, Tractography
in
Neuroradiology
volume
60
issue
3
pages
247 - 254
publisher
Springer Verlag
external identifiers
  • scopus:85040909610
ISSN
0028-3940
DOI
10.1007/s00234-017-1971-3
language
English
LU publication?
yes
id
ad5c7555-b5ef-4047-9a24-bfe1cb3eba0a
date added to LUP
2018-02-06 15:25:41
date last changed
2018-02-07 03:00:03
@article{ad5c7555-b5ef-4047-9a24-bfe1cb3eba0a,
  abstract     = {<p>Purpose: In Parkinson’s disease (PD), pathological microstructural changes occur that may be detected using diffusion magnetic resonance imaging (dMRI). However, there are few longitudinal studies that explore the effect of disease progression on diffusion indices. Methods: We prospectively included 76 patients with PD and 38 healthy controls (HC), all of whom underwent diffusion kurtosis imaging (DKI) as part of the prospective Swedish BioFINDER study at baseline and 2 years later. Annualized rates of change in DKI parameters, including fractional anisotropy (FA), mean diffusivity (MD), and mean kurtosis (MK), were estimated in the gray matter (GM) by placing regions of interest (ROIs) in the basal ganglia and the thalamus, and in the white matter (WM) by tract-based spatial statistics (TBSS) analysis. Results: When adjusting for potential confounding factors (age, gender, baseline-follow-up interval, and software upgrade of MRI scanner), only a decrease in FA in the putamen of PD patients (β = − 0.248, P &lt; .01) over 2 years was significantly different from the changes observed in HC over the same time period. This 2-year decrease in FA in the putamen in PD correlated with higher l-dopa equivalent dose at baseline (Spearman’s rho = .399, P &lt; .0001). Conclusion: The study indicates that in PD microstructural changes in the putamen occur selectively over a 2-year period and can be detected with DKI.</p>},
  author       = {Surova, Yulia and Nilsson, Markus and Lampinen, Björn and Lätt, Jimmy and Hall, Sara and Widner, Håkan and van Westen, Danielle and Hansson, Oskar},
  issn         = {0028-3940},
  keyword      = {Diffusion kurtosis imaging,Parkinson’s disease,Tract-based spatial statistics,Tractography},
  language     = {eng},
  number       = {3},
  pages        = {247--254},
  publisher    = {Springer Verlag},
  series       = {Neuroradiology},
  title        = {Alteration of putaminal fractional anisotropy in Parkinson’s disease : a longitudinal diffusion kurtosis imaging study},
  url          = {http://dx.doi.org/10.1007/s00234-017-1971-3},
  volume       = {60},
  year         = {2018},
}