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Body mass index and subsequent fracture risk: a meta-analysis to update FRAX

Harvey, N.C. ; Åkesson, K.E. LU ; Karlsson, M.K. LU ; McGuigan, F.E.A. LU orcid and Kanis, J.A. (2025) In Journal of Bone and Mineral Research 40(10). p.1144-1155
Abstract
The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1667922 men and women from 32 countries (63 cohorts), followed for a total of 16.0 million person-years were studied. 293325 had FN BMD measured (2.2 million person-years follow-up). An extended Poisson model in each cohort was used to investigate relationships between WHO-defined BMI categories (Underweight:
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author
; ; ; and
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BMI, epidemiology, FRAX, hip fracture, major osteoporotic fracture, meta-analysis, osteoporosis, Aged, Body Mass Index, Bone Density, Female, Fractures, Bone, Humans, Male, Middle Aged, Osteoporotic Fractures, Risk Factors, adult, age, Article, Asian, body mass, body weight, Caucasian, ethnicity, female, follow up, fracture risk assessment, fragility fracture, hazard ratio, human, major clinical study, male, meta analysis, mortality risk, obesity, proximal femur, risk factor, sex, underweight, World Health Organization, aged, bone density, fracture, middle aged
in
Journal of Bone and Mineral Research
volume
40
issue
10
pages
12 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:105017660752
  • pmid:40795319
ISSN
0884-0431
DOI
10.1093/jbmr/zjaf091
language
English
LU publication?
yes
id
ada8e6dd-45e2-4d90-a9d3-98228aee91ea
date added to LUP
2026-03-26 15:17:17
date last changed
2026-03-27 03:00:03
@article{ada8e6dd-45e2-4d90-a9d3-98228aee91ea,
  abstract     = {{The aim of this international meta-analysis was to quantify the predictive value of BMI for incident fracture and relationship of this risk with age, sex, follow-up time, and BMD. A total of 1667922 men and women from 32 countries (63 cohorts), followed for a total of 16.0 million person-years were studied. 293325 had FN BMD measured (2.2 million person-years follow-up). An extended Poisson model in each cohort was used to investigate relationships between WHO-defined BMI categories (Underweight:}},
  author       = {{Harvey, N.C. and Åkesson, K.E. and Karlsson, M.K. and McGuigan, F.E.A. and Kanis, J.A.}},
  issn         = {{0884-0431}},
  keywords     = {{BMI; epidemiology; FRAX; hip fracture; major osteoporotic fracture; meta-analysis; osteoporosis; Aged; Body Mass Index; Bone Density; Female; Fractures, Bone; Humans; Male; Middle Aged; Osteoporotic Fractures; Risk Factors; adult; age; Article; Asian; body mass; body weight; Caucasian; ethnicity; female; follow up; fracture risk assessment; fragility fracture; hazard ratio; human; major clinical study; male; meta analysis; mortality risk; obesity; proximal femur; risk factor; sex; underweight; World Health Organization; aged; bone density; fracture; middle aged}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1144--1155}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Bone and Mineral Research}},
  title        = {{Body mass index and subsequent fracture risk: a meta-analysis to update FRAX}},
  url          = {{http://dx.doi.org/10.1093/jbmr/zjaf091}},
  doi          = {{10.1093/jbmr/zjaf091}},
  volume       = {{40}},
  year         = {{2025}},
}