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The severity of post-infarction edema suggests a bimodal pattern, whereas the extent does not

Jablonowski, Robert LU ; Nordlund, David LU ; Xanthis, Christos LU ; Bidhult, Sebastian LU ; Kopic, Sascha LU ; Berg, Jonathan LU orcid ; Engblom, Henrik LU ; Aletras, Anthony H. LU orcid and Arheden, Håkan LU (2026) In Journal of Cardiovascular Magnetic Resonance 28(1).
Abstract

Background Preclinical and clinical data following acute myocardial infarction (MI) have shown conflicting results whether a bimodal pattern of edematous myocardium at risk (MaR) on cardiovascular magnetic resonance (CMR) imaging during the first week exists or not. The objective was to assess the dynamics of MaR following acute experimental MI using a comprehensive CMR protocol. Methods Acute MI was induced in seven pigs with reperfusion after 40 min. CMR was performed at baseline, 120 min, 24 h and 7 days post reperfusion. The CMR protocol comprised two T2-mapping sequences, a T2-SSFP sequence (T2-mappingSSFP) and a T2-TSE sequence (T2-mappingTSE), as well as a T2w short-tau inversion recovery (T2-STIR) sequence.... (More)

Background Preclinical and clinical data following acute myocardial infarction (MI) have shown conflicting results whether a bimodal pattern of edematous myocardium at risk (MaR) on cardiovascular magnetic resonance (CMR) imaging during the first week exists or not. The objective was to assess the dynamics of MaR following acute experimental MI using a comprehensive CMR protocol. Methods Acute MI was induced in seven pigs with reperfusion after 40 min. CMR was performed at baseline, 120 min, 24 h and 7 days post reperfusion. The CMR protocol comprised two T2-mapping sequences, a T2-SSFP sequence (T2-mappingSSFP) and a T2-TSE sequence (T2-mappingTSE), as well as a T2w short-tau inversion recovery (T2-STIR) sequence. After contrast administration, CE-SSFP and LGE images were acquired. The severity of MaR was defined as the T2 relaxation on T2 maps and the extent of MaR as percentage of edematous myocardium on CE-SSFP and T2-STIR images. Results The severity of edema within the MaR was significantly lower at 24 h compared to 120 min (T2 mappingSSFP:69±9 vs 80±8 ms; T2 mappingTSE:57±7 vs 69±9 ms), followed by a recovery at 7 days (T2 mappingSSFP:77±10 ms; T2 mappingTSE:67±12 ms). The extent of MaR showed a gradual decrease between 120 min and 24 h on CE-SSFP (29±10 vs 26±9%LVM) and at 7 days compared to both previous time points (CE-SSFP: 24±11%LVM). Conclusion The severity of edema within the MaR following acute MI suggests a bimodal pattern, whereas the extent of MaR does not.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CMR, myocardial edema, Myocardium at risk
in
Journal of Cardiovascular Magnetic Resonance
volume
28
issue
1
article number
102741
publisher
Elsevier
external identifiers
  • scopus:105040554990
  • pmid:42061680
ISSN
1097-6647
DOI
10.1016/j.jocmr.2026.102741
language
English
LU publication?
yes
id
adddb7ce-8b95-444a-b31c-13b6150a6ee5
date added to LUP
2026-08-20 16:09:44
date last changed
2026-09-17 17:57:08
@article{adddb7ce-8b95-444a-b31c-13b6150a6ee5,
  abstract     = {{<p>Background Preclinical and clinical data following acute myocardial infarction (MI) have shown conflicting results whether a bimodal pattern of edematous myocardium at risk (MaR) on cardiovascular magnetic resonance (CMR) imaging during the first week exists or not. The objective was to assess the dynamics of MaR following acute experimental MI using a comprehensive CMR protocol. Methods Acute MI was induced in seven pigs with reperfusion after 40 min. CMR was performed at baseline, 120 min, 24 h and 7 days post reperfusion. The CMR protocol comprised two T2-mapping sequences, a T2-SSFP sequence (T2-mapping<sub>SSFP</sub>) and a T2-TSE sequence (T2-mapping<sub>TSE</sub>), as well as a T2w short-tau inversion recovery (T2-STIR) sequence. After contrast administration, CE-SSFP and LGE images were acquired. The severity of MaR was defined as the T2 relaxation on T2 maps and the extent of MaR as percentage of edematous myocardium on CE-SSFP and T2-STIR images. Results The severity of edema within the MaR was significantly lower at 24 h compared to 120 min (T2 mapping<sub>SSFP</sub>:69±9 vs 80±8 ms; T2 mapping<sub>TSE</sub>:57±7 vs 69±9 ms), followed by a recovery at 7 days (T2 mapping<sub>SSFP</sub>:77±10 ms; T2 mapping<sub>TSE</sub>:67±12 ms). The extent of MaR showed a gradual decrease between 120 min and 24 h on CE-SSFP (29±10 vs 26±9%LVM) and at 7 days compared to both previous time points (CE-SSFP: 24±11%LVM). Conclusion The severity of edema within the MaR following acute MI suggests a bimodal pattern, whereas the extent of MaR does not.</p>}},
  author       = {{Jablonowski, Robert and Nordlund, David and Xanthis, Christos and Bidhult, Sebastian and Kopic, Sascha and Berg, Jonathan and Engblom, Henrik and Aletras, Anthony H. and Arheden, Håkan}},
  issn         = {{1097-6647}},
  keywords     = {{CMR; myocardial edema; Myocardium at risk}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{1}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Cardiovascular Magnetic Resonance}},
  title        = {{The severity of post-infarction edema suggests a bimodal pattern, whereas the extent does not}},
  url          = {{http://dx.doi.org/10.1016/j.jocmr.2026.102741}},
  doi          = {{10.1016/j.jocmr.2026.102741}},
  volume       = {{28}},
  year         = {{2026}},
}