Association of depression with incident sarcopenia and modified effect from healthy lifestyle : The first longitudinal evidence from the CHARLS
Liu, Yunyun ; Cui, Jiameng ; Cao, Limin ; Stubbendorff, Anna LU
and Zhang, Shunming
LU
(2024)
In Journal of Affective Disorders
344.
p.373-379
- Abstract
Background: The prospective association of depression with incident sarcopenia remains unknown, as does whether such an association is modified by a healthy lifestyle. Thus, the goal of this study was to determine whether depression is independently related to the risk of developing sarcopenia and to detect the effect of a healthy lifestyle on its modification. Methods: The prospective study included 9486 participants from the China Health and Retirement Longitudinal Study who were followed from 2011 to 2015. We calculated a lifestyle score based on body mass index, drinking, smoking, social activities, and sleeping time. Cox proportional hazards regression models with hazard ratios (HRs) and 95 % confidence intervals were used to... (More)
Background: The prospective association of depression with incident sarcopenia remains unknown, as does whether such an association is modified by a healthy lifestyle. Thus, the goal of this study was to determine whether depression is independently related to the risk of developing sarcopenia and to detect the effect of a healthy lifestyle on its modification. Methods: The prospective study included 9486 participants from the China Health and Retirement Longitudinal Study who were followed from 2011 to 2015. We calculated a lifestyle score based on body mass index, drinking, smoking, social activities, and sleeping time. Cox proportional hazards regression models with hazard ratios (HRs) and 95 % confidence intervals were used to estimate the effect of depression on the risk of sarcopenia and the modification effect of lifestyle (CIs). Results: During a mean of 3.53 years of follow-up, 1373 individuals developed sarcopenia. After adjusting for confounding factors, depression was significantly associated with a higher risk of incident sarcopenia (HR = 1.34; 95 % CI: 1.19, 1.50). In addition, we observed that individuals adhering to a healthy lifestyle had an 18 % lower risk of sarcopenia onset, compared with individuals with an unhealthy lifestyle. Limitations: We couldn't completely rule out potential residual bias due to its observational design. Second, ascertainment of the history of diseases in CHARLS was based on self-reported information, which may introduce recall bias or misclassification. Conclusions: Depression was associated with a higher risk of sarcopenia in Chinese adults, and such a risk may be alleviated by adhering to a healthy lifestyle.
(Less)
- author
- Liu, Yunyun
; Cui, Jiameng
; Cao, Limin
; Stubbendorff, Anna
LU
and Zhang, Shunming
LU
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Depression, Epidemiology, Healthy lifestyle, Primary prevention, Sarcopenia
- in
- Journal of Affective Disorders
- volume
- 344
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:37805156
- scopus:85174184675
- ISSN
- 0165-0327
- DOI
- 10.1016/j.jad.2023.10.012
- language
- English
- LU publication?
- yes
- id
- ae89dd11-7740-4ffb-b2a6-d17ed7ae27b6
- date added to LUP
- 2023-12-08 14:04:02
- date last changed
- 2024-04-21 07:58:32
@article{ae89dd11-7740-4ffb-b2a6-d17ed7ae27b6,
abstract = {{<p>Background: The prospective association of depression with incident sarcopenia remains unknown, as does whether such an association is modified by a healthy lifestyle. Thus, the goal of this study was to determine whether depression is independently related to the risk of developing sarcopenia and to detect the effect of a healthy lifestyle on its modification. Methods: The prospective study included 9486 participants from the China Health and Retirement Longitudinal Study who were followed from 2011 to 2015. We calculated a lifestyle score based on body mass index, drinking, smoking, social activities, and sleeping time. Cox proportional hazards regression models with hazard ratios (HRs) and 95 % confidence intervals were used to estimate the effect of depression on the risk of sarcopenia and the modification effect of lifestyle (CIs). Results: During a mean of 3.53 years of follow-up, 1373 individuals developed sarcopenia. After adjusting for confounding factors, depression was significantly associated with a higher risk of incident sarcopenia (HR = 1.34; 95 % CI: 1.19, 1.50). In addition, we observed that individuals adhering to a healthy lifestyle had an 18 % lower risk of sarcopenia onset, compared with individuals with an unhealthy lifestyle. Limitations: We couldn't completely rule out potential residual bias due to its observational design. Second, ascertainment of the history of diseases in CHARLS was based on self-reported information, which may introduce recall bias or misclassification. Conclusions: Depression was associated with a higher risk of sarcopenia in Chinese adults, and such a risk may be alleviated by adhering to a healthy lifestyle.</p>}},
author = {{Liu, Yunyun and Cui, Jiameng and Cao, Limin and Stubbendorff, Anna and Zhang, Shunming}},
issn = {{0165-0327}},
keywords = {{Depression; Epidemiology; Healthy lifestyle; Primary prevention; Sarcopenia}},
language = {{eng}},
pages = {{373--379}},
publisher = {{Elsevier}},
series = {{Journal of Affective Disorders}},
title = {{Association of depression with incident sarcopenia and modified effect from healthy lifestyle : The first longitudinal evidence from the CHARLS}},
url = {{http://dx.doi.org/10.1016/j.jad.2023.10.012}},
doi = {{10.1016/j.jad.2023.10.012}},
volume = {{344}},
year = {{2024}},
}