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Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents

Guath, Mona ; Kleberg, Johan Lundin ; Weis, Jan ; Widegren, Ebba ; Frick, Matilda ; Möller, Stefan LU ; Klevebrant, Lisa ; Karlsson, Barry ; Fällmar, David and Mårtensson, Johanna , et al. (2023) In Behavioural Brain Research 436.
Abstract

Depressive symptoms are associated with altered pupillary responses during learning and reward prediction as well as with changes in neurometabolite levels, including brain concentrations of choline, glutamate and gamma-aminobutyric acid (GABA). However, the full link between depressive symptoms, reward-learning-related pupillary responses and neurometabolites is yet to be established as these constructs have not been assessed in the same individuals. The present pilot study, investigated these relations in a sample of 24 adolescents aged 13 years. Participants completed the Revised Child Anxiety and Depression Scale (RCADS) and underwent a reward learning task while measuring pupil dilation and a single voxel dorsal anterior cingulate... (More)

Depressive symptoms are associated with altered pupillary responses during learning and reward prediction as well as with changes in neurometabolite levels, including brain concentrations of choline, glutamate and gamma-aminobutyric acid (GABA). However, the full link between depressive symptoms, reward-learning-related pupillary responses and neurometabolites is yet to be established as these constructs have not been assessed in the same individuals. The present pilot study, investigated these relations in a sample of 24 adolescents aged 13 years. Participants completed the Revised Child Anxiety and Depression Scale (RCADS) and underwent a reward learning task while measuring pupil dilation and a single voxel dorsal anterior cingulate cortex (dACC) MEGA-PRESS magnetic resonance spectroscopy scan assessing choline, glutamate and GABA concentrations. Pupil dilation was related to prediction errors (PE) during learning, which was captured by a prediction error-weighted pupil dilation response index (PE-PDR) for each individual. Higher PE-PDR scores, indicating larger pupil dilations to negative prediction errors, were related to lower depressive symptoms and lower dACC choline concentrations. Dorsal ACC choline was positively associated with depressive symptoms, whereas glutamate and GABA were not related to PE-PDR or depressive symptoms. The findings support notions of cholinergic involvement in depressive symptoms and cholinergic influence on reward-related pupillary response, suggesting that pupillary responses to negative prediction errors may hold promise as a biomarker of depressive states.

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type
Contribution to journal
publication status
published
subject
keywords
Magnetic resonance spectroscopy, Mood disorders, Operant conditioning, Reward learning
in
Behavioural Brain Research
volume
436
article number
114060
publisher
Elsevier
external identifiers
  • scopus:85136649805
  • pmid:35987307
ISSN
0166-4328
DOI
10.1016/j.bbr.2022.114060
language
English
LU publication?
yes
id
ae98ae69-300b-4d0b-9f1d-edbb32bce777
date added to LUP
2022-10-14 07:51:42
date last changed
2024-06-29 00:05:41
@article{ae98ae69-300b-4d0b-9f1d-edbb32bce777,
  abstract     = {{<p>Depressive symptoms are associated with altered pupillary responses during learning and reward prediction as well as with changes in neurometabolite levels, including brain concentrations of choline, glutamate and gamma-aminobutyric acid (GABA). However, the full link between depressive symptoms, reward-learning-related pupillary responses and neurometabolites is yet to be established as these constructs have not been assessed in the same individuals. The present pilot study, investigated these relations in a sample of 24 adolescents aged 13 years. Participants completed the Revised Child Anxiety and Depression Scale (RCADS) and underwent a reward learning task while measuring pupil dilation and a single voxel dorsal anterior cingulate cortex (dACC) MEGA-PRESS magnetic resonance spectroscopy scan assessing choline, glutamate and GABA concentrations. Pupil dilation was related to prediction errors (PE) during learning, which was captured by a prediction error-weighted pupil dilation response index (PE-PDR) for each individual. Higher PE-PDR scores, indicating larger pupil dilations to negative prediction errors, were related to lower depressive symptoms and lower dACC choline concentrations. Dorsal ACC choline was positively associated with depressive symptoms, whereas glutamate and GABA were not related to PE-PDR or depressive symptoms. The findings support notions of cholinergic involvement in depressive symptoms and cholinergic influence on reward-related pupillary response, suggesting that pupillary responses to negative prediction errors may hold promise as a biomarker of depressive states.</p>}},
  author       = {{Guath, Mona and Kleberg, Johan Lundin and Weis, Jan and Widegren, Ebba and Frick, Matilda and Möller, Stefan and Klevebrant, Lisa and Karlsson, Barry and Fällmar, David and Mårtensson, Johanna and Pine, Daniel S. and Brocki, Karin and Gingnell, Malin and Frick, Andreas}},
  issn         = {{0166-4328}},
  keywords     = {{Magnetic resonance spectroscopy; Mood disorders; Operant conditioning; Reward learning}},
  language     = {{eng}},
  month        = {{01}},
  publisher    = {{Elsevier}},
  series       = {{Behavioural Brain Research}},
  title        = {{Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents}},
  url          = {{http://dx.doi.org/10.1016/j.bbr.2022.114060}},
  doi          = {{10.1016/j.bbr.2022.114060}},
  volume       = {{436}},
  year         = {{2023}},
}