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Existence and coexistence of peptides in nerves of the mammalian ovary and oviduct demonstrated by immunocytochemistry

Kannisto, P LU ; Ekblad, E LU ; Helm, G ; Owman, C LU ; Sjöberg, N O LU ; Stjernquist, M LU ; Sundler, F LU and Walles, Bengt (1986) In Histochemistry 86(1). p.25-34
Abstract

The immunocytochemical distribution of substance P (SP), gastrin releasing peptide (GRP), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), and neuropeptide Y (NPY) was studied in the ovary and the Fallopian tube (oviduct) of rats, guinea-pigs, cows, pigs and humans. Generally, the nerve supply was better developed in the oviduct than in the ovary. GRP fibers were most scarce in all tissues. Nerves containing SP were particularly numerous in the oviduct of rat and guinea-pig, supplying the muscular wall and blood vessels. VIP and PHI coexisted in dense plexuses of nerves, not only around blood vessels but also in the follicular wall and the interstitial gland of the ovary, as well as within the smooth muscle... (More)

The immunocytochemical distribution of substance P (SP), gastrin releasing peptide (GRP), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), and neuropeptide Y (NPY) was studied in the ovary and the Fallopian tube (oviduct) of rats, guinea-pigs, cows, pigs and humans. Generally, the nerve supply was better developed in the oviduct than in the ovary. GRP fibers were most scarce in all tissues. Nerves containing SP were particularly numerous in the oviduct of rat and guinea-pig, supplying the muscular wall and blood vessels. VIP and PHI coexisted in dense plexuses of nerves, not only around blood vessels but also in the follicular wall and the interstitial gland of the ovary, as well as within the smooth muscle layers and subepithelially in the oviduct. The general distribution of NPY was similar, but these immunoreactive nerves were even more numerous. Sequential staining for dopamine-beta-hydroxylase and NPY together with results of chemical sympathectomy with 6-hydroxydopamine suggested that NPY was stored in the noradrenergic sympathetic nerves.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Animals, Cattle, Dopamine beta-Hydroxylase/analysis, Fallopian Tubes/innervation, Female, Fluorescent Antibody Technique, Guinea Pigs, Histocytochemistry, Humans, Nerve Tissue/metabolism, Neuropeptides/analysis, Ovary/innervation, Rats, Rats, Inbred Strains, Swine
in
Histochemistry
volume
86
issue
1
pages
25 - 34
publisher
Springer
external identifiers
  • pmid:3539891
  • scopus:0022884806
ISSN
0301-5564
DOI
10.1007/bf00492342
language
English
LU publication?
yes
id
aeb37380-9806-40ea-a4ca-88085ae96481
date added to LUP
2019-12-03 22:12:29
date last changed
2024-01-02 01:38:18
@article{aeb37380-9806-40ea-a4ca-88085ae96481,
  abstract     = {{<p>The immunocytochemical distribution of substance P (SP), gastrin releasing peptide (GRP), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), and neuropeptide Y (NPY) was studied in the ovary and the Fallopian tube (oviduct) of rats, guinea-pigs, cows, pigs and humans. Generally, the nerve supply was better developed in the oviduct than in the ovary. GRP fibers were most scarce in all tissues. Nerves containing SP were particularly numerous in the oviduct of rat and guinea-pig, supplying the muscular wall and blood vessels. VIP and PHI coexisted in dense plexuses of nerves, not only around blood vessels but also in the follicular wall and the interstitial gland of the ovary, as well as within the smooth muscle layers and subepithelially in the oviduct. The general distribution of NPY was similar, but these immunoreactive nerves were even more numerous. Sequential staining for dopamine-beta-hydroxylase and NPY together with results of chemical sympathectomy with 6-hydroxydopamine suggested that NPY was stored in the noradrenergic sympathetic nerves.</p>}},
  author       = {{Kannisto, P and Ekblad, E and Helm, G and Owman, C and Sjöberg, N O and Stjernquist, M and Sundler, F and Walles, Bengt}},
  issn         = {{0301-5564}},
  keywords     = {{Animals; Cattle; Dopamine beta-Hydroxylase/analysis; Fallopian Tubes/innervation; Female; Fluorescent Antibody Technique; Guinea Pigs; Histocytochemistry; Humans; Nerve Tissue/metabolism; Neuropeptides/analysis; Ovary/innervation; Rats; Rats, Inbred Strains; Swine}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{25--34}},
  publisher    = {{Springer}},
  series       = {{Histochemistry}},
  title        = {{Existence and coexistence of peptides in nerves of the mammalian ovary and oviduct demonstrated by immunocytochemistry}},
  url          = {{http://dx.doi.org/10.1007/bf00492342}},
  doi          = {{10.1007/bf00492342}},
  volume       = {{86}},
  year         = {{1986}},
}