Transplantation and surgical treatment of parkinsonian syndromes
(1993) In Current Opinion in Neurology and Neurosurgery 6(3). p.9-344- Abstract
Neurosurgical attempts to correct parkinsonism use strategies aimed either at alleviating the underlying dopamine deficiency or at correcting abnormal compensatory effects in neural circuits within the basal ganglia. During the review period, clinical trials of four different neurosurgical approaches were reported. These approaches are intracerebral transplantation of fetal dopamine neurons, intracerebral transplantation of adrenal medullary tissue, tremor-reducing surgical lesions in the ventrolateral thalamus, and ventroposterior pallidotomy aimed at reducing akinesia and rigidity. Experimental studies in rats and monkeys designed to explore mechanisms of graft actions were also reported.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/af4d5656-d771-4920-a3ec-a3185333969b
- author
- Widner, H LU and Rehncrona, S LU
- organization
- publishing date
- 1993-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adrenal Medulla, Animals, Dopamine, Globus Pallidus, Humans, Parkinson Disease, Parkinson Disease, Secondary, Receptors, Dopamine, Thalamus, Journal Article, Review
- in
- Current Opinion in Neurology and Neurosurgery
- volume
- 6
- issue
- 3
- pages
- 6 pages
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- scopus:0027155159
- pmid:8507904
- ISSN
- 0951-7383
- language
- English
- LU publication?
- yes
- id
- af4d5656-d771-4920-a3ec-a3185333969b
- date added to LUP
- 2017-04-19 18:29:40
- date last changed
- 2025-01-07 11:42:37
@article{af4d5656-d771-4920-a3ec-a3185333969b,
abstract = {{<p>Neurosurgical attempts to correct parkinsonism use strategies aimed either at alleviating the underlying dopamine deficiency or at correcting abnormal compensatory effects in neural circuits within the basal ganglia. During the review period, clinical trials of four different neurosurgical approaches were reported. These approaches are intracerebral transplantation of fetal dopamine neurons, intracerebral transplantation of adrenal medullary tissue, tremor-reducing surgical lesions in the ventrolateral thalamus, and ventroposterior pallidotomy aimed at reducing akinesia and rigidity. Experimental studies in rats and monkeys designed to explore mechanisms of graft actions were also reported.</p>}},
author = {{Widner, H and Rehncrona, S}},
issn = {{0951-7383}},
keywords = {{Adrenal Medulla; Animals; Dopamine; Globus Pallidus; Humans; Parkinson Disease; Parkinson Disease, Secondary; Receptors, Dopamine; Thalamus; Journal Article; Review}},
language = {{eng}},
number = {{3}},
pages = {{9--344}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Current Opinion in Neurology and Neurosurgery}},
title = {{Transplantation and surgical treatment of parkinsonian syndromes}},
volume = {{6}},
year = {{1993}},
}