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Transplantation and surgical treatment of parkinsonian syndromes

Widner, H LU and Rehncrona, S LU (1993) In Current Opinion in Neurology and Neurosurgery 6(3). p.9-344
Abstract

Neurosurgical attempts to correct parkinsonism use strategies aimed either at alleviating the underlying dopamine deficiency or at correcting abnormal compensatory effects in neural circuits within the basal ganglia. During the review period, clinical trials of four different neurosurgical approaches were reported. These approaches are intracerebral transplantation of fetal dopamine neurons, intracerebral transplantation of adrenal medullary tissue, tremor-reducing surgical lesions in the ventrolateral thalamus, and ventroposterior pallidotomy aimed at reducing akinesia and rigidity. Experimental studies in rats and monkeys designed to explore mechanisms of graft actions were also reported.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adrenal Medulla, Animals, Dopamine, Globus Pallidus, Humans, Parkinson Disease, Parkinson Disease, Secondary, Receptors, Dopamine, Thalamus, Journal Article, Review
in
Current Opinion in Neurology and Neurosurgery
volume
6
issue
3
pages
6 pages
publisher
Lippincott Williams and Wilkins
external identifiers
  • scopus:0027155159
ISSN
0951-7383
language
English
LU publication?
yes
id
af4d5656-d771-4920-a3ec-a3185333969b
date added to LUP
2017-04-19 18:29:40
date last changed
2017-08-24 15:32:26
@article{af4d5656-d771-4920-a3ec-a3185333969b,
  abstract     = {<p>Neurosurgical attempts to correct parkinsonism use strategies aimed either at alleviating the underlying dopamine deficiency or at correcting abnormal compensatory effects in neural circuits within the basal ganglia. During the review period, clinical trials of four different neurosurgical approaches were reported. These approaches are intracerebral transplantation of fetal dopamine neurons, intracerebral transplantation of adrenal medullary tissue, tremor-reducing surgical lesions in the ventrolateral thalamus, and ventroposterior pallidotomy aimed at reducing akinesia and rigidity. Experimental studies in rats and monkeys designed to explore mechanisms of graft actions were also reported.</p>},
  author       = {Widner, H and Rehncrona, S},
  issn         = {0951-7383},
  keyword      = {Adrenal Medulla,Animals,Dopamine,Globus Pallidus,Humans,Parkinson Disease,Parkinson Disease, Secondary,Receptors, Dopamine,Thalamus,Journal Article,Review},
  language     = {eng},
  number       = {3},
  pages        = {9--344},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Current Opinion in Neurology and Neurosurgery},
  title        = {Transplantation and surgical treatment of parkinsonian syndromes},
  volume       = {6},
  year         = {1993},
}