Risk of incident and fatal melanoma in individuals with a family history of incident or fatal melanoma or any cancer.
(2011) In British Journal of Dermatology 165. p.342-348- Abstract
- Background: A family history of melanoma is associated with an increased risk of melanoma and probably of other, discordant cancers. Limited data are available on familial mortality in melanoma. If fatal forms of melanoma were associated with fatal forms of melanoma or of some other cancers, only studies on familial mortality rather than on familial incidence might be able to detect them. Furthermore, estimates on familial aggregation based on mortality are free from bias of overdiagnosis. Objectives: The aim of this study was the estimation of familial aggregation of concordant melanoma and of melanoma and any other cancers both based on incidence and mortality. Methods: We used the nation-wide Swedish Family-Cancer Database to calculate... (More)
- Background: A family history of melanoma is associated with an increased risk of melanoma and probably of other, discordant cancers. Limited data are available on familial mortality in melanoma. If fatal forms of melanoma were associated with fatal forms of melanoma or of some other cancers, only studies on familial mortality rather than on familial incidence might be able to detect them. Furthermore, estimates on familial aggregation based on mortality are free from bias of overdiagnosis. Objectives: The aim of this study was the estimation of familial aggregation of concordant melanoma and of melanoma and any other cancers both based on incidence and mortality. Methods: We used the nation-wide Swedish Family-Cancer Database to calculate standardized incidence ratios (SIR) for incident melanoma for relatives of any cancer patients and standardized mortality ratios (SMR) for death in melanoma for relatives of individuals who died from any other cancer. Similar risks were determined for any common cancer when relatives were affected by melanoma. Results: For concordant melanoma, familial incidence equalled familial mortality, SIR=SMR. Familial clustering (SIRs increased) of melanoma and esophageal, colorectal, breast, prostate, kidney, nervous system and connective tissue cancers and myeloma and leukaemia was observed. The SMRs for pancreatic and nervous system cancers were increased in relatives whose parents had died from melanoma. Conclusions: These data should encourage search for fatal subtypes of familial cancer, which may eventually have clinical implications. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1937634
- author
- Brandt, Andreas LU ; Sundquist, Jan LU and Hemminki, Kari LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Dermatology
- volume
- 165
- pages
- 342 - 348
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000292926900018
- pmid:21457213
- scopus:79960637237
- pmid:21457213
- ISSN
- 1365-2133
- DOI
- 10.1111/j.1365-2133.2011.10350.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Family Medicine (013241010), Psychiatry/Primary Care/Public Health (013240500)
- id
- b093b712-8873-4508-9705-91a70bdef3ac (old id 1937634)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21457213?dopt=Abstract
- date added to LUP
- 2016-04-04 08:31:43
- date last changed
- 2022-03-15 08:18:57
@article{b093b712-8873-4508-9705-91a70bdef3ac, abstract = {{Background: A family history of melanoma is associated with an increased risk of melanoma and probably of other, discordant cancers. Limited data are available on familial mortality in melanoma. If fatal forms of melanoma were associated with fatal forms of melanoma or of some other cancers, only studies on familial mortality rather than on familial incidence might be able to detect them. Furthermore, estimates on familial aggregation based on mortality are free from bias of overdiagnosis. Objectives: The aim of this study was the estimation of familial aggregation of concordant melanoma and of melanoma and any other cancers both based on incidence and mortality. Methods: We used the nation-wide Swedish Family-Cancer Database to calculate standardized incidence ratios (SIR) for incident melanoma for relatives of any cancer patients and standardized mortality ratios (SMR) for death in melanoma for relatives of individuals who died from any other cancer. Similar risks were determined for any common cancer when relatives were affected by melanoma. Results: For concordant melanoma, familial incidence equalled familial mortality, SIR=SMR. Familial clustering (SIRs increased) of melanoma and esophageal, colorectal, breast, prostate, kidney, nervous system and connective tissue cancers and myeloma and leukaemia was observed. The SMRs for pancreatic and nervous system cancers were increased in relatives whose parents had died from melanoma. Conclusions: These data should encourage search for fatal subtypes of familial cancer, which may eventually have clinical implications.}}, author = {{Brandt, Andreas and Sundquist, Jan and Hemminki, Kari}}, issn = {{1365-2133}}, language = {{eng}}, pages = {{342--348}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Dermatology}}, title = {{Risk of incident and fatal melanoma in individuals with a family history of incident or fatal melanoma or any cancer.}}, url = {{http://dx.doi.org/10.1111/j.1365-2133.2011.10350.x}}, doi = {{10.1111/j.1365-2133.2011.10350.x}}, volume = {{165}}, year = {{2011}}, }