Stem cell therapy for human neurodegenerative disorders-how to make it work
Lindvall, Olle LU ; Kokaia, Zaal LU
and Martinez-Serrano, A
(2004)
In Nature Reviews Neuroscience
10(Suppl.).
p.42-50
- Abstract
- Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative disorders. Before clinical trials are initiated, we need to know much more about how to control stem cell proliferation and differentiation into specific phenotypes, induce their integration into existing neural and synaptic circuits, and optimize functional recovery in animal models closely resembling the human disease.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/270728
- author
- Lindvall, Olle
LU
; Kokaia, Zaal
LU
and Martinez-Serrano, A
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews Neuroscience
- volume
- 10
- issue
- Suppl.
- pages
- 42 - 50
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000223202200007
- wos:000223202100007
- scopus:3142521479
- ISSN
- 1471-003X
- DOI
- 10.1038/nm1064
- language
- English
- LU publication?
- yes
- id
- b0f56740-b745-49a9-9a55-c002bc4a7f67 (old id 270728)
- date added to LUP
- 2016-04-01 17:08:26
- date last changed
- 2022-04-23 02:58:46
@article{b0f56740-b745-49a9-9a55-c002bc4a7f67,
abstract = {{Recent progress shows that neurons suitable for transplantation can be generated from stem cells in culture, and that the adult brain produces new neurons from its own stem cells in response to injury. These findings raise hope for the development of stem cell therapies in human neurodegenerative disorders. Before clinical trials are initiated, we need to know much more about how to control stem cell proliferation and differentiation into specific phenotypes, induce their integration into existing neural and synaptic circuits, and optimize functional recovery in animal models closely resembling the human disease.}},
author = {{Lindvall, Olle and Kokaia, Zaal and Martinez-Serrano, A}},
issn = {{1471-003X}},
language = {{eng}},
number = {{Suppl.}},
pages = {{42--50}},
publisher = {{Nature Publishing Group}},
series = {{Nature Reviews Neuroscience}},
title = {{Stem cell therapy for human neurodegenerative disorders-how to make it work}},
url = {{http://dx.doi.org/10.1038/nm1064}},
doi = {{10.1038/nm1064}},
volume = {{10}},
year = {{2004}},
}