Postmenopausal overweight and breast cancer risk; results from the KARMA cohort
(2022) In Breast Cancer Research and Treatment 196(1). p.185-196- Abstract
Purpose: To study the risk of incident breast cancer and subtype-specific breast cancer in relation to excess body weight in a contemporary Swedish prospective cohort study, The Karolinska Mammography Project for Risk Prediction of Breast Cancer, KARMA. Methods: A total of 35,412 postmenopausal women attending mammography and included in the KARMA study provided baseline data on body mass index (BMI) and potential confounders. During eight years of follow-up, 822 incident invasive breast cancer cases were identified. Results: Women with overweight (BMI ≥ 25–< 30 kg/m2) constituting 34% of the study cohort had an increased risk of incident breast cancer with an adjusted Hazard Ratio (HRadj) 1.19 (95% CI... (More)
Purpose: To study the risk of incident breast cancer and subtype-specific breast cancer in relation to excess body weight in a contemporary Swedish prospective cohort study, The Karolinska Mammography Project for Risk Prediction of Breast Cancer, KARMA. Methods: A total of 35,412 postmenopausal women attending mammography and included in the KARMA study provided baseline data on body mass index (BMI) and potential confounders. During eight years of follow-up, 822 incident invasive breast cancer cases were identified. Results: Women with overweight (BMI ≥ 25–< 30 kg/m2) constituting 34% of the study cohort had an increased risk of incident breast cancer with an adjusted Hazard Ratio (HRadj) 1.19 (95% CI 1.01–1.4). A similar, however, non-significant, association was found for women with obesity (BMI ≥ 30 kg/m2) conferring 13% of the cohort, with a HRadj of 1.19 (95% CI 0.94–1.5). Overweight was associated with risk of node-negative disease (HRadj 1.29, 95% CI 1.06–1.58), whereas obesity was associated with node-positive disease (HRadj 1.64, 95% CI 1.09–2.48). Both overweight and obesity were associated with risk of estrogen receptor positive (ER+) disease (HRadj 1.20, 95% CI 1.00–1.44 and HRadj 1.33, 95% CI 1.03–1.71, respectively), and low-grade tumors (HRadj 1.25, 95% CI 1.02–1.54, and HRadj 1.40, 95% CI 1.05–1.86, respectively). Finally, obesity was associated with ER+HER2 negative disease (HRadj 1.37, 95% CI 1.05–1.78) and similarly luminal A tumors (HRadj 1.43, 95% CI 1.02–2.01). Conclusion: Overweight and obesity are associated with an increased risk of developing breast cancer, specifically ER+, low-grade, and for obesity, node-positive, high-risk breast cancer indicating a further need for risk communication and preventive programs.
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- author
- Klintman, Marie LU ; Rosendahl, Ann H. LU ; Randeris, Benjamin ; Eriksson, Mikael LU ; Czene, Kamila ; Hall, Per LU and Borgquist, Signe LU
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- BMI, Breast cancer risk, Breast cancer subtypes, Obesity, Overweight
- in
- Breast Cancer Research and Treatment
- volume
- 196
- issue
- 1
- pages
- 12 pages
- publisher
- Springer
- external identifiers
-
- scopus:85137222850
- pmid:36040641
- ISSN
- 0167-6806
- DOI
- 10.1007/s10549-022-06664-7
- language
- English
- LU publication?
- yes
- id
- b14920de-3f37-4962-ac0b-1d59d057cce8
- date added to LUP
- 2022-11-14 15:42:28
- date last changed
- 2024-06-11 21:09:03
@article{b14920de-3f37-4962-ac0b-1d59d057cce8,
abstract = {{<p>Purpose: To study the risk of incident breast cancer and subtype-specific breast cancer in relation to excess body weight in a contemporary Swedish prospective cohort study, The Karolinska Mammography Project for Risk Prediction of Breast Cancer, KARMA. Methods: A total of 35,412 postmenopausal women attending mammography and included in the KARMA study provided baseline data on body mass index (BMI) and potential confounders. During eight years of follow-up, 822 incident invasive breast cancer cases were identified. Results: Women with overweight (BMI ≥ 25–< 30 kg/m<sup>2</sup>) constituting 34% of the study cohort had an increased risk of incident breast cancer with an adjusted Hazard Ratio (HR<sub>adj</sub>) 1.19 (95% CI 1.01–1.4). A similar, however, non-significant, association was found for women with obesity (BMI ≥ 30 kg/m<sup>2</sup>) conferring 13% of the cohort, with a HR<sub>adj</sub> of 1.19 (95% CI 0.94–1.5). Overweight was associated with risk of node-negative disease (HR<sub>adj</sub> 1.29, 95% CI 1.06–1.58), whereas obesity was associated with node-positive disease (HR<sub>adj</sub> 1.64, 95% CI 1.09–2.48). Both overweight and obesity were associated with risk of estrogen receptor positive (ER+) disease (HR<sub>adj</sub> 1.20, 95% CI 1.00–1.44 and HR<sub>adj</sub> 1.33, 95% CI 1.03–1.71, respectively), and low-grade tumors (HR<sub>adj</sub> 1.25, 95% CI 1.02–1.54, and HR<sub>adj</sub> 1.40, 95% CI 1.05–1.86, respectively). Finally, obesity was associated with ER+HER2 negative disease (HR<sub>adj</sub> 1.37, 95% CI 1.05–1.78) and similarly luminal A tumors (HR<sub>adj</sub> 1.43, 95% CI 1.02–2.01). Conclusion: Overweight and obesity are associated with an increased risk of developing breast cancer, specifically ER+, low-grade, and for obesity, node-positive, high-risk breast cancer indicating a further need for risk communication and preventive programs.</p>}},
author = {{Klintman, Marie and Rosendahl, Ann H. and Randeris, Benjamin and Eriksson, Mikael and Czene, Kamila and Hall, Per and Borgquist, Signe}},
issn = {{0167-6806}},
keywords = {{BMI; Breast cancer risk; Breast cancer subtypes; Obesity; Overweight}},
language = {{eng}},
number = {{1}},
pages = {{185--196}},
publisher = {{Springer}},
series = {{Breast Cancer Research and Treatment}},
title = {{Postmenopausal overweight and breast cancer risk; results from the KARMA cohort}},
url = {{http://dx.doi.org/10.1007/s10549-022-06664-7}},
doi = {{10.1007/s10549-022-06664-7}},
volume = {{196}},
year = {{2022}},
}