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Vibrotactile sense in children with type 1 diabetes

Ising, Erik LU ; Dahlin, Lars LU orcid and Elding Larsson, Helena LU (2017) In Diabetes 66(Suppl 1). p.153-153
Abstract
Introduction: Diabetic peripheral neuropathy (DPN) is a devastating complication to DM, potentially leading to diabetic foot ulcers. Studies using
electrophysiology shows high occurrence of subclinical DPN among children,
but it is unclear when and how to start screen children with T1D for DPN.
Aim: To investigate whether evaluation of the vibrotactile sense, using
a multi-frequency method, in the right hand and foot can detect underlying sensory neuropathy in children with T1D, and whether the DPN has any
correlation to, for example, gender, age, duration of disease and metabolic
control measured as HbA1c values.
Methods: Vibration perception thresholds (VPTs), resulting in curves
and numeric values, were... (More)
Introduction: Diabetic peripheral neuropathy (DPN) is a devastating complication to DM, potentially leading to diabetic foot ulcers. Studies using
electrophysiology shows high occurrence of subclinical DPN among children,
but it is unclear when and how to start screen children with T1D for DPN.
Aim: To investigate whether evaluation of the vibrotactile sense, using
a multi-frequency method, in the right hand and foot can detect underlying sensory neuropathy in children with T1D, and whether the DPN has any
correlation to, for example, gender, age, duration of disease and metabolic
control measured as HbA1c values.
Methods: Vibration perception thresholds (VPTs), resulting in curves
and numeric values, were evaluated using a VibroSense Meter. VPTs were
related to normative data obtained from healthy children, and evaluated in
relation to different characteristics.
Subjects were 8-18 years old T1D patients. Subjects that failed to produce
at least one visibly evaluable curve were excluded. Z-values of >2.0 were
considered pathological. Subjects needed at least 3 pathological frequencies at the same site in order to claim the examined site as pathological.
Results: 73 children (boys = 39) with mean age 13.2 [8.39-17.96] years
and duration of T1D of 5.9 [0.54-14.58] years met the inclusion and exclusion criteria. On index and little fingers, 5/73 (6.8%) and 4/73 (5.5%) children
respectively had pathological values. On metatarsal heads one and five,
9/73 (12.3%) children had pathological values on each site. In total 15/73
(21.0%) children had at least one pathological site and 3 (4.1%) had pathological values on all sites examined. Presence of pathological values on all
sites correlated to the height of the subject (p = 0.011) but not to gender,
duration of disease or HbA1c.
Conclusion: Our findings suggests that DPN, reflected by impaired vibrotactile sense, is present among children with T1D. Since up to 21% of the
children showed signs of impaired vibrotactile sense, it may be important to
screen children with T1D for early detection of DPN. (Less)
Abstract (Swedish)
Poster A153
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
A153
in
Diabetes
volume
66
issue
Suppl 1
article number
586-P
pages
153 - 153
publisher
American Diabetes Association Inc.
ISSN
1939-327X
DOI
10.2337/db17-381-663
language
English
LU publication?
yes
id
b1d54b67-8d03-402a-981c-114f9dc1e89e
date added to LUP
2021-09-27 22:51:46
date last changed
2021-09-29 09:56:49
@misc{b1d54b67-8d03-402a-981c-114f9dc1e89e,
  abstract     = {{Introduction: Diabetic peripheral neuropathy (DPN) is a devastating complication to DM, potentially leading to diabetic foot ulcers. Studies using<br>
electrophysiology shows high occurrence of subclinical DPN among children,<br>
but it is unclear when and how to start screen children with T1D for DPN.<br>
Aim: To investigate whether evaluation of the vibrotactile sense, using<br>
a multi-frequency method, in the right hand and foot can detect underlying sensory neuropathy in children with T1D, and whether the DPN has any<br>
correlation to, for example, gender, age, duration of disease and metabolic<br>
control measured as HbA1c values.<br>
Methods: Vibration perception thresholds (VPTs), resulting in curves<br>
and numeric values, were evaluated using a VibroSense Meter. VPTs were<br>
related to normative data obtained from healthy children, and evaluated in<br>
relation to different characteristics.<br>
Subjects were 8-18 years old T1D patients. Subjects that failed to produce<br>
at least one visibly evaluable curve were excluded. Z-values of &gt;2.0 were<br>
considered pathological. Subjects needed at least 3 pathological frequencies at the same site in order to claim the examined site as pathological.<br>
Results: 73 children (boys = 39) with mean age 13.2 [8.39-17.96] years<br>
and duration of T1D of 5.9 [0.54-14.58] years met the inclusion and exclusion criteria. On index and little fingers, 5/73 (6.8%) and 4/73 (5.5%) children<br>
respectively had pathological values. On metatarsal heads one and five,<br>
9/73 (12.3%) children had pathological values on each site. In total 15/73<br>
(21.0%) children had at least one pathological site and 3 (4.1%) had pathological values on all sites examined. Presence of pathological values on all<br>
sites correlated to the height of the subject (p = 0.011) but not to gender,<br>
duration of disease or HbA1c.<br>
Conclusion: Our findings suggests that DPN, reflected by impaired vibrotactile sense, is present among children with T1D. Since up to 21% of the<br>
children showed signs of impaired vibrotactile sense, it may be important to<br>
screen children with T1D for early detection of DPN.}},
  author       = {{Ising, Erik and Dahlin, Lars and Elding Larsson, Helena}},
  issn         = {{1939-327X}},
  keywords     = {{A153}},
  language     = {{eng}},
  note         = {{Conference Abstract}},
  number       = {{Suppl 1}},
  pages        = {{153--153}},
  publisher    = {{American Diabetes Association Inc.}},
  series       = {{Diabetes}},
  title        = {{Vibrotactile sense in children with type 1 diabetes}},
  url          = {{http://dx.doi.org/10.2337/db17-381-663}},
  doi          = {{10.2337/db17-381-663}},
  volume       = {{66}},
  year         = {{2017}},
}