Population-based study of multisystem inflammatory syndrome associated with COVID-19 found that 36% of children had persistent symptoms
(2022) In Acta Paediatrica, International Journal of Paediatrics- Abstract
- Aim
Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19.
Methods
This national, population-based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS-C. The outcomes 2 and 8 weeks after diagnosis are presented, and follow-up protocols are suggested.
Results
We identified 152 cases, and 133 (87%) participated. When followed up 2 weeks after MIS-C was diagnosed, 43% of the 119 patients had abnormal results, including complete blood cell counts, platelet counts, albumin levels, electrocardiograms and... (More) - Aim
Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19.
Methods
This national, population-based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS-C. The outcomes 2 and 8 weeks after diagnosis are presented, and follow-up protocols are suggested.
Results
We identified 152 cases, and 133 (87%) participated. When followed up 2 weeks after MIS-C was diagnosed, 43% of the 119 patients had abnormal results, including complete blood cell counts, platelet counts, albumin levels, electrocardiograms and echocardiograms. After 8 weeks, 36% of 89 had an abnormal patient history, but clinical findings were uncommon. Echocardiogram results were abnormal in 5% of 67, and the most common complaint was fatigue. Older children and those who received intensive care were more likely to report symptoms and have abnormal cardiac results.
Conclusion
More than a third (36%) of the patients had persistent symptoms 8 weeks after MIS-C, and 5% had abnormal echocardiograms. Older age and higher levels of initial care appeared to be risk factors. Structured follow-up visits are important after MIS-C. (Less)
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- author
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Paediatrica, International Journal of Paediatrics
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:34806789
- scopus:85120312006
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.16191
- language
- English
- LU publication?
- yes
- id
- b314f899-c1c3-4705-bf76-78987cb31c32
- date added to LUP
- 2021-11-21 00:56:24
- date last changed
- 2024-02-20 16:35:17
@article{b314f899-c1c3-4705-bf76-78987cb31c32, abstract = {{Aim<br/>Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19.<br/><br/>Methods<br/>This national, population-based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS-C. The outcomes 2 and 8 weeks after diagnosis are presented, and follow-up protocols are suggested.<br/><br/>Results<br/>We identified 152 cases, and 133 (87%) participated. When followed up 2 weeks after MIS-C was diagnosed, 43% of the 119 patients had abnormal results, including complete blood cell counts, platelet counts, albumin levels, electrocardiograms and echocardiograms. After 8 weeks, 36% of 89 had an abnormal patient history, but clinical findings were uncommon. Echocardiogram results were abnormal in 5% of 67, and the most common complaint was fatigue. Older children and those who received intensive care were more likely to report symptoms and have abnormal cardiac results.<br/><br/>Conclusion<br/>More than a third (36%) of the patients had persistent symptoms 8 weeks after MIS-C, and 5% had abnormal echocardiograms. Older age and higher levels of initial care appeared to be risk factors. Structured follow-up visits are important after MIS-C.}}, author = {{Kahn, Robin and Berg, Stefan and Berntson, Lillemor and Berthold, Elisabet and Brodin, Petter and Bäckström, Fredrik and Compagno, Michele and Fasth, Anders and Lingman Framme, Jenny and Horne, AnnaCarin and Hätting, Josefin and Król, Petra and Kukka, Antti J. and Mossberg, Maria and Månsson, Bengt and Nordenhäll, Charlotta and Idring Nordström, Selma and Khammari Nyström, Fatine and Palmblad, Karin and Rasti, Reza and Rudolf, André and Rydenman, Karin and Sundberg, Erik and Säve-Söderbergh, Eva and Altman, Maria}}, issn = {{0803-5253}}, language = {{eng}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Paediatrica, International Journal of Paediatrics}}, title = {{Population-based study of multisystem inflammatory syndrome associated with COVID-19 found that 36% of children had persistent symptoms}}, url = {{http://dx.doi.org/10.1111/apa.16191}}, doi = {{10.1111/apa.16191}}, year = {{2022}}, }