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Thalassemia and sickle cell anemia in Swedish immigrants : Genetic diseases have become global

Hemminki, Kari LU ; Li, Xinjun LU ; Försti, Asta LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2015) In SAGE Open 3.
Abstract

AIMS: Some 15% of the Swedish population is born outside Sweden, originating from all continents of the world. Thalassemia and sickle cell anemia constitute the most common inherited recessive disorders globally and they are endemic in areas of Africa and Asia, origins of many immigrants to Sweden. We aimed at investigating the origins of the Swedish sickle cell and thalassemia patients.

METHODS: Patients were identified using data from the Swedish Hospital Discharge Register since 1987 and from the Outpatient Register since 2001 up to year 2010.

RESULTS: A total of 3064 persons were diagnosed with thalassemia. The incidence was highest, 62.9/100,000 for immigrants from Thailand, followed by Iraqis (47.1/100,000); the rate... (More)

AIMS: Some 15% of the Swedish population is born outside Sweden, originating from all continents of the world. Thalassemia and sickle cell anemia constitute the most common inherited recessive disorders globally and they are endemic in areas of Africa and Asia, origins of many immigrants to Sweden. We aimed at investigating the origins of the Swedish sickle cell and thalassemia patients.

METHODS: Patients were identified using data from the Swedish Hospital Discharge Register since 1987 and from the Outpatient Register since 2001 up to year 2010.

RESULTS: A total of 3064 persons were diagnosed with thalassemia. The incidence was highest, 62.9/100,000 for immigrants from Thailand, followed by Iraqis (47.1/100,000); the rate was 0.7/100,000 among those born in Sweden. The total number of sickle cell anemia patients was 584 and the highest rate of 13.0/100,000 was found for Sub-Saharan immigrants. For thalassemia, 363 of the patients were siblings, while for sickle cell anemia, 180 were siblings.

CONCLUSIONS: The data showed that >90% of sickle cell and thalassemia patients were first- or second-generation immigrants to Sweden and the endemic regions for these were the origins of immigrants with the highest incidence. Global immigration provides global challenges to national health care systems.

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publication status
published
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in
SAGE Open
volume
3
publisher
Sage Open
ISSN
2050-3121
DOI
10.1177/2050312115613097
language
English
LU publication?
yes
id
b323b21a-4538-466d-94f6-501cb9b4774e
date added to LUP
2019-01-30 10:50:29
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2019-02-08 08:59:10
@article{b323b21a-4538-466d-94f6-501cb9b4774e,
  abstract     = {<p>AIMS: Some 15% of the Swedish population is born outside Sweden, originating from all continents of the world. Thalassemia and sickle cell anemia constitute the most common inherited recessive disorders globally and they are endemic in areas of Africa and Asia, origins of many immigrants to Sweden. We aimed at investigating the origins of the Swedish sickle cell and thalassemia patients.</p><p>METHODS: Patients were identified using data from the Swedish Hospital Discharge Register since 1987 and from the Outpatient Register since 2001 up to year 2010.</p><p>RESULTS: A total of 3064 persons were diagnosed with thalassemia. The incidence was highest, 62.9/100,000 for immigrants from Thailand, followed by Iraqis (47.1/100,000); the rate was 0.7/100,000 among those born in Sweden. The total number of sickle cell anemia patients was 584 and the highest rate of 13.0/100,000 was found for Sub-Saharan immigrants. For thalassemia, 363 of the patients were siblings, while for sickle cell anemia, 180 were siblings.</p><p>CONCLUSIONS: The data showed that &gt;90% of sickle cell and thalassemia patients were first- or second-generation immigrants to Sweden and the endemic regions for these were the origins of immigrants with the highest incidence. Global immigration provides global challenges to national health care systems.</p>},
  author       = {Hemminki, Kari and Li, Xinjun and Försti, Asta and Sundquist, Jan and Sundquist, Kristina},
  issn         = {2050-3121},
  language     = {eng},
  publisher    = {Sage Open},
  series       = {SAGE Open},
  title        = {Thalassemia and sickle cell anemia in Swedish immigrants : Genetic diseases have become global},
  url          = {http://dx.doi.org/10.1177/2050312115613097},
  volume       = {3},
  year         = {2015},
}