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Computer simulation analysis of source-detector position for percutaneously measured O2-gas signal in a three-dimensional preterm infant lung

Liao, Peilang; Larsson, Jim LU ; Krite Svanberg, Emilie LU ; Lundin, Patrik LU ; Swartling, Johannes; Lewander Xu, Märta; Bood, Joakim LU and Andersson-Engels, Stefan LU (2018) In Journal of Biophotonics 11(11).
Abstract

Further improvements in the clinical care of our most vulnerable patients-preterm infants-are needed. Novel diagnostic and surveillance tools facilitate such advances. The GASMAS technique has shown potential to become a tool to, noninvasively, monitor gas in the lungs of preterm infants, by placing a laser source and a detector on the chest wall skin. It is believed that this technology will become a valuable clinical diagnostic tool for monitoring the lung function of these patients. Today, the technology is, for this application, in an early stage and further investigations are needed. In the present study, a three-dimensional computer model of the thorax of an infant is constructed, from a set of CT images. Light transport... (More)

Further improvements in the clinical care of our most vulnerable patients-preterm infants-are needed. Novel diagnostic and surveillance tools facilitate such advances. The GASMAS technique has shown potential to become a tool to, noninvasively, monitor gas in the lungs of preterm infants, by placing a laser source and a detector on the chest wall skin. It is believed that this technology will become a valuable clinical diagnostic tool for monitoring the lung function of these patients. Today, the technology is, for this application, in an early stage and further investigations are needed. In the present study, a three-dimensional computer model of the thorax of an infant is constructed, from a set of CT images. Light transport simulations are performed to provide information about the position dependence of the laser- and detector probe on the thorax of the infant. The result of the simulations, based on the study method and the specified model used in this work, indicates that measurement geometries in front and on the side of the lung are favorable in order to obtain a good gas absorption signal.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Computational phantom, Light transport simulation, Preterm infants, Respiratory distress syndrome, Tunable diode laser absorption spectroscopy
in
Journal of Biophotonics
volume
11
issue
11
publisher
John Wiley & Sons
external identifiers
  • scopus:85050999982
ISSN
1864-063X
DOI
10.1002/jbio.201800023
language
English
LU publication?
yes
id
b3a0ed98-4e89-4822-8cd3-6bf3f0b73449
date added to LUP
2018-09-12 12:32:37
date last changed
2019-02-20 11:26:36
@article{b3a0ed98-4e89-4822-8cd3-6bf3f0b73449,
  abstract     = {<p>Further improvements in the clinical care of our most vulnerable patients-preterm infants-are needed. Novel diagnostic and surveillance tools facilitate such advances. The GASMAS technique has shown potential to become a tool to, noninvasively, monitor gas in the lungs of preterm infants, by placing a laser source and a detector on the chest wall skin. It is believed that this technology will become a valuable clinical diagnostic tool for monitoring the lung function of these patients. Today, the technology is, for this application, in an early stage and further investigations are needed. In the present study, a three-dimensional computer model of the thorax of an infant is constructed, from a set of CT images. Light transport simulations are performed to provide information about the position dependence of the laser- and detector probe on the thorax of the infant. The result of the simulations, based on the study method and the specified model used in this work, indicates that measurement geometries in front and on the side of the lung are favorable in order to obtain a good gas absorption signal.</p>},
  articleno    = {e201800023},
  author       = {Liao, Peilang and Larsson, Jim and Krite Svanberg, Emilie and Lundin, Patrik and Swartling, Johannes and Lewander Xu, Märta and Bood, Joakim and Andersson-Engels, Stefan},
  issn         = {1864-063X},
  keyword      = {Computational phantom,Light transport simulation,Preterm infants,Respiratory distress syndrome,Tunable diode laser absorption spectroscopy},
  language     = {eng},
  month        = {07},
  number       = {11},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Biophotonics},
  title        = {Computer simulation analysis of source-detector position for percutaneously measured O<sub>2</sub>-gas signal in a three-dimensional preterm infant lung},
  url          = {http://dx.doi.org/10.1002/jbio.201800023},
  volume       = {11},
  year         = {2018},
}