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Diagnosis and management of bone fragility in diabetes : an emerging challenge

, ; Ferrari, S. L.; Abrahamsen, B.; Napoli, N.; Akesson, K. LU ; Chandran, M.; Eastell, R.; El-Hajj Fuleihan, G.; Josse, R. and Kendler, D. L., et al. (2018) In Osteoporosis International 29(12). p.2585-2596
Abstract

Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for... (More)

Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.

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Contribution to journal
publication status
published
subject
keywords
Diabetes, Diabetes-related bone disease, Fracture, Osteoporosis
in
Osteoporosis International
volume
29
issue
12
pages
2585 - 2596
publisher
Springer
external identifiers
  • scopus:85051441673
ISSN
0937-941X
DOI
10.1007/s00198-018-4650-2
language
English
LU publication?
yes
id
b4070e3f-8e0c-4f5a-989d-12b1b9f3081d
date added to LUP
2018-09-13 12:10:47
date last changed
2019-01-20 05:58:12
@article{b4070e3f-8e0c-4f5a-989d-12b1b9f3081d,
  abstract     = {<p>Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies that have evaluated bone mineral density (BMD), bone microstructure and material properties, biochemical markers, and fracture prediction algorithms (i.e., FRAX) in these patients. It further reviews the impact of diabetes drugs on bone as well as the efficacy of osteoporosis treatments in this population. We finally propose an algorithm for the identification and management of diabetic patients at increased fracture risk.</p>},
  author       = {,  and Ferrari, S. L. and Abrahamsen, B. and Napoli, N. and Akesson, K. and Chandran, M. and Eastell, R. and El-Hajj Fuleihan, G. and Josse, R. and Kendler, D. L. and Kraenzlin, M. and Suzuki, A. and Pierroz, D. D. and Schwartz, A. V. and Leslie, W. D.},
  issn         = {0937-941X},
  keyword      = {Diabetes,Diabetes-related bone disease,Fracture,Osteoporosis},
  language     = {eng},
  number       = {12},
  pages        = {2585--2596},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {Diagnosis and management of bone fragility in diabetes : an emerging challenge},
  url          = {http://dx.doi.org/10.1007/s00198-018-4650-2},
  volume       = {29},
  year         = {2018},
}