Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition
(2010) In International Journal of Cancer 127(2). p.442-451- Abstract
- Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelated and whether they act independently still requires clarification. We conducted a study to examine the association of menstrual and reproductive variables with the risk of endometrial cancer among the European Prospective Investigation into Cancer and Nutrition (EPIC). Among the 302,618 women eligible for the study, 1,017 incident endometrial cancer cases were identified. A reduction in endometrial cancer risk was observed in women with late menarche, early menopause, past OC use, high parity... (More)
- Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelated and whether they act independently still requires clarification. We conducted a study to examine the association of menstrual and reproductive variables with the risk of endometrial cancer among the European Prospective Investigation into Cancer and Nutrition (EPIC). Among the 302,618 women eligible for the study, 1,017 incident endometrial cancer cases were identified. A reduction in endometrial cancer risk was observed in women with late menarche, early menopause, past OC use, high parity and a shorter time since last full-term pregnancy (FTP). No association was observed for duration of breast feeding after adjustment for number of FTP or for abortion (spontaneous or induced). After mutual adjustment, late age at menarche, early age at menopause and duration of OC use showed similar risk reductions of 7-8% per year of menstrual life, whereas the decreased risk associated with cumulative duration of FTPs was stronger (22% per year). In conclusion, our findings confirmed a reduction in risk of endometrial cancer with factors associated with a lower cumulative exposure to estrogen and/or higher exposure to progesterone, such as increasing number of FTPs and shorter menstrual lifespan and, therefore, support an important role of hormonal mechanisms in endometrial carcinogenesis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1630418
- author
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- menopause, menarche, endometrial cancer, parity, oral contraceptive
- in
- International Journal of Cancer
- volume
- 127
- issue
- 2
- pages
- 442 - 451
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000278919000020
- scopus:77953707725
- pmid:19924816
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.25050
- language
- English
- LU publication?
- yes
- id
- b491084a-ee7e-4366-a112-38b5bc3b7c6c (old id 1630418)
- date added to LUP
- 2016-04-01 10:45:44
- date last changed
- 2022-04-20 05:57:32
@article{b491084a-ee7e-4366-a112-38b5bc3b7c6c,
abstract = {{Endometrial cancer risk has been associated with reproductive factors (age at menarche, age at menopause, parity, age at first and last birth, time since last birth and use of oral contraceptives (OCs)]. However, these factors are closely interrelated and whether they act independently still requires clarification. We conducted a study to examine the association of menstrual and reproductive variables with the risk of endometrial cancer among the European Prospective Investigation into Cancer and Nutrition (EPIC). Among the 302,618 women eligible for the study, 1,017 incident endometrial cancer cases were identified. A reduction in endometrial cancer risk was observed in women with late menarche, early menopause, past OC use, high parity and a shorter time since last full-term pregnancy (FTP). No association was observed for duration of breast feeding after adjustment for number of FTP or for abortion (spontaneous or induced). After mutual adjustment, late age at menarche, early age at menopause and duration of OC use showed similar risk reductions of 7-8% per year of menstrual life, whereas the decreased risk associated with cumulative duration of FTPs was stronger (22% per year). In conclusion, our findings confirmed a reduction in risk of endometrial cancer with factors associated with a lower cumulative exposure to estrogen and/or higher exposure to progesterone, such as increasing number of FTPs and shorter menstrual lifespan and, therefore, support an important role of hormonal mechanisms in endometrial carcinogenesis.}},
author = {{Dossus, Laure and Allen, Naomi and Kaaks, Rudolf and Bakken, Kjersti and Lund, Eiliv and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Clavel-Chapelon, Francoise and Fournier, Agnes and Chabbert-Buffet, Nathalie and Boeing, Heiner and Schuetze, Madlen and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Lagiou, Pagona and Palli, Domenico and Krogh, Vittorio and Tumino, Rosario and Vineis, Paolo and Mattiello, Amalia and Bueno-de-Mesquita, H. Bas and Onland-Moret, N. Charlotte and Peeters, Petra H. M. and Dumeaux, Vanessa and Redondo, Maria-Luisa and Duell, Eric and Sanchez-Cantalejo, Emilio and Arriola, Larraitz and Chirlaque, Maria-Dolores and Ardanaz, Eva and Manjer, Jonas and Borgquist, Signe and Lukanova, Annie and Lundin, Eva and Khaw, Kay-Tee and Wareham, Nicholas and Key, Tim and Chajes, Veronique and Rinaldi, Sabina and Slimani, Nadia and Mouw, Traci and Gallo, Valentina and Riboli, Elio}},
issn = {{0020-7136}},
keywords = {{menopause; menarche; endometrial cancer; parity; oral contraceptive}},
language = {{eng}},
number = {{2}},
pages = {{442--451}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Cancer}},
title = {{Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition}},
url = {{http://dx.doi.org/10.1002/ijc.25050}},
doi = {{10.1002/ijc.25050}},
volume = {{127}},
year = {{2010}},
}