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Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children

Ambalavanan, Amirthagowri ; Chang, Le ; Choi, Jihoon ; Zhang, Yang ; Stickley, Sara A. ; Fang, Zhi Y. ; Miliku, Kozeta ; Robertson, Bianca ; Yonemitsu, Chloe and Turvey, Stuart E. , et al. (2024) In Nature Communications 15(1).
Abstract

Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating human milk oligosaccharides (HMOs), and their associations with respiratory health among human milk-fed infants. Nineteen HMOs are quantified from 980 mothers of the CHILD Cohort Study. Genome-wide association studies identify HMO-associated loci on chromosome 19p13.3 and 19q13.33 (lowest P = 2.4e–118), spanning several fucosyltransferase (FUT) genes. We identify novel associations on chromosome 3q27.3 for 6′-sialyllactose (P = 2.2e–9) in the sialyltransferase (ST6GAL1) gene. These, plus additional... (More)

Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating human milk oligosaccharides (HMOs), and their associations with respiratory health among human milk-fed infants. Nineteen HMOs are quantified from 980 mothers of the CHILD Cohort Study. Genome-wide association studies identify HMO-associated loci on chromosome 19p13.3 and 19q13.33 (lowest P = 2.4e–118), spanning several fucosyltransferase (FUT) genes. We identify novel associations on chromosome 3q27.3 for 6′-sialyllactose (P = 2.2e–9) in the sialyltransferase (ST6GAL1) gene. These, plus additional associations on chromosomes 7q21.32, 7q31.32 and 13q33.3, are replicated in the independent INSPIRE Cohort. Moreover, gene-environment interaction analyses suggest that fucosylated HMOs may modulate overall risk of recurrent wheeze among preschoolers with variable genetic risk scores (P < 0.01). Thus, we report novel genetic factors associated with HMOs, some of which may protect the respiratory health of children.

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organization
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type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
15
issue
1
article number
7735
publisher
Nature Publishing Group
external identifiers
  • scopus:85203265719
  • pmid:39232002
ISSN
2041-1723
DOI
10.1038/s41467-024-51743-6
language
English
LU publication?
yes
id
b550de03-f05a-48ec-b6c9-841fd970ed46
date added to LUP
2024-11-13 14:34:27
date last changed
2025-05-29 07:08:42
@article{b550de03-f05a-48ec-b6c9-841fd970ed46,
  abstract     = {{<p>Breastfeeding provides many health benefits, but its impact on respiratory health remains unclear. This study addresses the complex and dynamic nature of the mother-milk-infant triad by investigating maternal genomic factors regulating human milk oligosaccharides (HMOs), and their associations with respiratory health among human milk-fed infants. Nineteen HMOs are quantified from 980 mothers of the CHILD Cohort Study. Genome-wide association studies identify HMO-associated loci on chromosome 19p13.3 and 19q13.33 (lowest P = 2.4e–118), spanning several fucosyltransferase (FUT) genes. We identify novel associations on chromosome 3q27.3 for 6′-sialyllactose (P = 2.2e–9) in the sialyltransferase (ST6GAL1) gene. These, plus additional associations on chromosomes 7q21.32, 7q31.32 and 13q33.3, are replicated in the independent INSPIRE Cohort. Moreover, gene-environment interaction analyses suggest that fucosylated HMOs may modulate overall risk of recurrent wheeze among preschoolers with variable genetic risk scores (P &lt; 0.01). Thus, we report novel genetic factors associated with HMOs, some of which may protect the respiratory health of children.</p>}},
  author       = {{Ambalavanan, Amirthagowri and Chang, Le and Choi, Jihoon and Zhang, Yang and Stickley, Sara A. and Fang, Zhi Y. and Miliku, Kozeta and Robertson, Bianca and Yonemitsu, Chloe and Turvey, Stuart E. and Mandhane, Piushkumar J. and Simons, Elinor and Moraes, Theo J. and Anand, Sonia S. and Paré, Guillaume and Williams, Janet E. and Murdoch, Brenda M. and Otoo, Gloria E. and Mbugua, Samwel and Kamau-Mbuthia, Elizabeth W. and Kamundia, Egidioh W. and Gindola, Debela K. and Rodriguez, Juan M. and Pareja, Rossina G. and Sellen, Daniel W. and Moore, Sophie E. and Prentice, Andrew M. and Foster, James A. and Kvist, Linda J. and Neibergs, Holly L. and McGuire, Mark A. and McGuire, Michelle K. and Meehan, Courtney L. and Sears, Malcolm R. and Subbarao, Padmaja and Azad, Meghan B. and Bode, Lars and Duan, Qingling}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Human milk oligosaccharides are associated with maternal genetics and respiratory health of human milk-fed children}},
  url          = {{http://dx.doi.org/10.1038/s41467-024-51743-6}},
  doi          = {{10.1038/s41467-024-51743-6}},
  volume       = {{15}},
  year         = {{2024}},
}