Advanced

Familial associations of lymphoma and myeloma with autoimmune diseases

Hemminki, K. LU ; Försti, A. LU ; Sundquist, K. LU ; Sundquist, J. LU and Li, X. (2017) In Blood Cancer Journal 7(1).
Abstract

Many B-cell neoplasms are associated with autoimmune diseases (AIDs) but most evidence is based on a personal rather than a family history of AIDs. Here we calculated risks for non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL) and multiple myeloma (MM) when family members were diagnosed with any of 44 different AIDs, or, independently, risk for AIDs when family members were diagnosed with a neoplasm. A total of 64 418 neoplasms and 531 155 AIDs were identified from Swedish nationwide health care records. NHL was associated with a family history of five AIDs, all increasing the risk, HL was associated with one AID increasing and three AIDs decreasing the risk while MM had no association. A family history of NHL was associated with eight,... (More)

Many B-cell neoplasms are associated with autoimmune diseases (AIDs) but most evidence is based on a personal rather than a family history of AIDs. Here we calculated risks for non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL) and multiple myeloma (MM) when family members were diagnosed with any of 44 different AIDs, or, independently, risk for AIDs when family members were diagnosed with a neoplasm. A total of 64 418 neoplasms and 531 155 AIDs were identified from Swedish nationwide health care records. NHL was associated with a family history of five AIDs, all increasing the risk, HL was associated with one AID increasing and three AIDs decreasing the risk while MM had no association. A family history of NHL was associated with eight, HL with seven and MM with seven different AIDs, nine increasing and 13 decreasing the risk. The present family data on B-cell neoplasms and AIDs show an approximately equal number of associations for risk increase and risk decrease, suggesting that inherited genes or geneenvironment interactions may increase the risk or be protective. These results differed from published data on personal history of AID, which only report increased risks, often vastly higher and for different AIDs compared with the present data.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Cancer Journal
volume
7
issue
1
publisher
Nature Publishing Group
external identifiers
  • scopus:85037554985
  • wos:000393787000003
ISSN
2044-5385
DOI
10.1038/bcj.2016.123
language
English
LU publication?
yes
id
b5907e35-c721-4e2c-8d02-d34d83bfaa2c
date added to LUP
2018-01-11 11:18:55
date last changed
2018-01-16 13:29:37
@article{b5907e35-c721-4e2c-8d02-d34d83bfaa2c,
  abstract     = {<p>Many B-cell neoplasms are associated with autoimmune diseases (AIDs) but most evidence is based on a personal rather than a family history of AIDs. Here we calculated risks for non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL) and multiple myeloma (MM) when family members were diagnosed with any of 44 different AIDs, or, independently, risk for AIDs when family members were diagnosed with a neoplasm. A total of 64 418 neoplasms and 531 155 AIDs were identified from Swedish nationwide health care records. NHL was associated with a family history of five AIDs, all increasing the risk, HL was associated with one AID increasing and three AIDs decreasing the risk while MM had no association. A family history of NHL was associated with eight, HL with seven and MM with seven different AIDs, nine increasing and 13 decreasing the risk. The present family data on B-cell neoplasms and AIDs show an approximately equal number of associations for risk increase and risk decrease, suggesting that inherited genes or geneenvironment interactions may increase the risk or be protective. These results differed from published data on personal history of AID, which only report increased risks, often vastly higher and for different AIDs compared with the present data.</p>},
  articleno    = {e515},
  author       = {Hemminki, K. and Försti, A. and Sundquist, K. and Sundquist, J. and Li, X.},
  issn         = {2044-5385},
  language     = {eng},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Blood Cancer Journal},
  title        = {Familial associations of lymphoma and myeloma with autoimmune diseases},
  url          = {http://dx.doi.org/10.1038/bcj.2016.123},
  volume       = {7},
  year         = {2017},
}