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Titanium granules pre-treated with hydrogen peroxide inhibit growth of bacteria associated with post-operative infections in spine surgery

Ohlin, Acke LU ; Mattsson, Emma LU ; Mörgelin, Matthias LU ; Davies, Julia R.; Svensäter, Gunnel; Corvec, Stéphane; Tengvall, Pentti and Riesbeck, Kristian LU (2018) In European Spine Journal 27(10). p.2463-2468
Abstract

Purpose: Post-operative infections are relatively common after posterior spine surgery, and there are several observations reflecting different infection complications related to various metals implanted. Here, we selected an array of different bacterial species that are often found in infections associated with orthopaedic implants and tested for inhibition by hydrogen peroxide-treated titanium (Ti-peroxy). Methods: To study the possibility of using Ti-peroxy as an antimicrobial prophylaxis, we developed a protocol for standardized susceptibility testing of bacteria. Results: Importantly, we found that the resulting Ti-peroxy was highly antimicrobial against all aerobic species tested, among others, Staphylococcus aureus and... (More)

Purpose: Post-operative infections are relatively common after posterior spine surgery, and there are several observations reflecting different infection complications related to various metals implanted. Here, we selected an array of different bacterial species that are often found in infections associated with orthopaedic implants and tested for inhibition by hydrogen peroxide-treated titanium (Ti-peroxy). Methods: To study the possibility of using Ti-peroxy as an antimicrobial prophylaxis, we developed a protocol for standardized susceptibility testing of bacteria. Results: Importantly, we found that the resulting Ti-peroxy was highly antimicrobial against all aerobic species tested, among others, Staphylococcus aureus and Pseudomonas aeruginosa. Proteus mirabilis was slightly more resistant than, for example, Klebsiella pneumoniae and enterococci. In contrast, anaerobic bacteria Cutibacterium acnes and Parvimonas micra were equally susceptible compared to staphylococci. Conclusions: Our findings suggest that the Ti-peroxy is a promising perioperative antimicrobial strategy that may be highly effective for prevention of post-operative infections. We therefore suggest application of hydrogen peroxide to implants prior to implantation. Graphical abstract: These slides can be retrieved under Electronic supplementary material.[Figure not available: see fulltext.]

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bacteria, Growth, Hydrogen peroxide, Titanium, Titanium peroxy
in
European Spine Journal
volume
27
issue
10
pages
2463 - 2468
publisher
Springer
external identifiers
  • scopus:85046549064
ISSN
0940-6719
DOI
10.1007/s00586-018-5619-8
language
English
LU publication?
yes
id
b62feabe-9c69-4005-896e-13f9447ea4b6
date added to LUP
2018-05-24 13:10:28
date last changed
2019-03-19 03:55:10
@article{b62feabe-9c69-4005-896e-13f9447ea4b6,
  abstract     = {<p>Purpose: Post-operative infections are relatively common after posterior spine surgery, and there are several observations reflecting different infection complications related to various metals implanted. Here, we selected an array of different bacterial species that are often found in infections associated with orthopaedic implants and tested for inhibition by hydrogen peroxide-treated titanium (Ti-peroxy). Methods: To study the possibility of using Ti-peroxy as an antimicrobial prophylaxis, we developed a protocol for standardized susceptibility testing of bacteria. Results: Importantly, we found that the resulting Ti-peroxy was highly antimicrobial against all aerobic species tested, among others, Staphylococcus aureus and Pseudomonas aeruginosa. Proteus mirabilis was slightly more resistant than, for example, Klebsiella pneumoniae and enterococci. In contrast, anaerobic bacteria Cutibacterium acnes and Parvimonas micra were equally susceptible compared to staphylococci. Conclusions: Our findings suggest that the Ti-peroxy is a promising perioperative antimicrobial strategy that may be highly effective for prevention of post-operative infections. We therefore suggest application of hydrogen peroxide to implants prior to implantation. Graphical abstract: These slides can be retrieved under Electronic supplementary material.[Figure not available: see fulltext.]</p>},
  author       = {Ohlin, Acke and Mattsson, Emma and Mörgelin, Matthias and Davies, Julia R. and Svensäter, Gunnel and Corvec, Stéphane and Tengvall, Pentti and Riesbeck, Kristian},
  issn         = {0940-6719},
  keyword      = {Bacteria,Growth,Hydrogen peroxide,Titanium,Titanium peroxy},
  language     = {eng},
  month        = {05},
  number       = {10},
  pages        = {2463--2468},
  publisher    = {Springer},
  series       = {European Spine Journal},
  title        = {Titanium granules pre-treated with hydrogen peroxide inhibit growth of bacteria associated with post-operative infections in spine surgery},
  url          = {http://dx.doi.org/10.1007/s00586-018-5619-8},
  volume       = {27},
  year         = {2018},
}