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Von Willebrand disease - the 'Dos' and 'Don'ts' in surgery

Miesbach, Wolfgang and Berntorp, Erik LU (2017) In European Journal of Haematology 98(2). p.121-127
Abstract

Von Willebrand disease (VWD) is the most common genetic bleeding disorder. VWD is caused by a deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and binds and stabilises coagulation factor VIII (FVIII) in the blood. Prophylaxis of surgical bleeding in patients with VWD requires consideration of the individual situation, including the type of procedure and the bleeding rate, before decisions about treatment type, dose, duration and adjunctive therapy with antifibrinolytics or antithrombotic prophylaxis can be made. Although desmopressin (DDAVP)-stimulated release of endogenous VWD is an effective treatment strategy in many patients, plasma... (More)

Von Willebrand disease (VWD) is the most common genetic bleeding disorder. VWD is caused by a deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and binds and stabilises coagulation factor VIII (FVIII) in the blood. Prophylaxis of surgical bleeding in patients with VWD requires consideration of the individual situation, including the type of procedure and the bleeding rate, before decisions about treatment type, dose, duration and adjunctive therapy with antifibrinolytics or antithrombotic prophylaxis can be made. Although desmopressin (DDAVP)-stimulated release of endogenous VWD is an effective treatment strategy in many patients, plasma concentrates containing VWF are the preferred option for most patients undergoing surgical procedures. Recommendations for the management of surgery in patients with VWD are summarised, including the severity of VWD and the type of the surgical procedure.

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type
Contribution to journal
publication status
published
subject
keywords
Desmopressin, Recommendation, Surgery, Thromboembolic event, Von Willebrand disease, Von Willebrand factor concentrate
in
European Journal of Haematology
volume
98
issue
2
pages
121 - 127
publisher
Wiley-Blackwell
external identifiers
  • pmid:27622750
  • wos:000393167400003
  • scopus:84991467130
ISSN
0902-4441
DOI
10.1111/ejh.12809
language
English
LU publication?
yes
id
b6d47b4f-b03e-4cac-a96b-e95bc67ace18
date added to LUP
2016-11-08 11:33:03
date last changed
2025-03-08 19:15:26
@article{b6d47b4f-b03e-4cac-a96b-e95bc67ace18,
  abstract     = {{<p>Von Willebrand disease (VWD) is the most common genetic bleeding disorder. VWD is caused by a deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury and binds and stabilises coagulation factor VIII (FVIII) in the blood. Prophylaxis of surgical bleeding in patients with VWD requires consideration of the individual situation, including the type of procedure and the bleeding rate, before decisions about treatment type, dose, duration and adjunctive therapy with antifibrinolytics or antithrombotic prophylaxis can be made. Although desmopressin (DDAVP)-stimulated release of endogenous VWD is an effective treatment strategy in many patients, plasma concentrates containing VWF are the preferred option for most patients undergoing surgical procedures. Recommendations for the management of surgery in patients with VWD are summarised, including the severity of VWD and the type of the surgical procedure.</p>}},
  author       = {{Miesbach, Wolfgang and Berntorp, Erik}},
  issn         = {{0902-4441}},
  keywords     = {{Desmopressin; Recommendation; Surgery; Thromboembolic event; Von Willebrand disease; Von Willebrand factor concentrate}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{121--127}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{European Journal of Haematology}},
  title        = {{Von Willebrand disease - the 'Dos' and 'Don'ts' in surgery}},
  url          = {{http://dx.doi.org/10.1111/ejh.12809}},
  doi          = {{10.1111/ejh.12809}},
  volume       = {{98}},
  year         = {{2017}},
}