Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland.
(2012) In Reproductive Toxicology- Abstract
- This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations... (More)
- This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3160983
- author
- Kvist, Linus LU ; Giwercman, Yvonne LU ; Jönsson, Bo A LU ; Lindh, Christian LU ; Bonde, Jens-Peter ; Toft, Gunnar ; Strucinski, Pawel ; Pedersen, Henning S ; Zvyezday, Valentyna and Giwercman, Aleksander LU
- organization
- publishing date
- 2012-10-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Reproductive Toxicology
- publisher
- Elsevier
- external identifiers
-
- wos:000312427600019
- pmid:23044208
- scopus:84868224674
- pmid:23044208
- ISSN
- 1873-1708
- DOI
- 10.1016/j.reprotox.2012.09.007
- language
- English
- LU publication?
- yes
- id
- b6fd1212-234c-4398-b6ad-5464294a7b4c (old id 3160983)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23044208?dopt=Abstract
- date added to LUP
- 2016-04-01 14:13:45
- date last changed
- 2022-01-27 23:28:57
@article{b6fd1212-234c-4398-b6ad-5464294a7b4c, abstract = {{This study investigated whether perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS), which exhibit reproductive toxicity in experimental animals, affect sperm sex chromosome ratio. The Y:X ratio was determined by fluorescence in situ hybridization. Serum concentrations of PFOA and PFOS were measured in 607 men from Greenland, Poland and Ukraine using liquid chromatography-tandem mass spectrometry. Data was analyzed by linear and nonlinear regression. We observed no associations between PFOA and Y:X ratio (p=0.845 in a linear model, p=0.296 in a nonlinear model). A positive nonlinear association between PFOS and Y:X ratio was observed (p=0.016), with no association in a linear model (p=0.118). Analyzing the populations separately, a negative trend between categorized PFOS exposure and Y:X ratio was observed for the Inuit (B=-0.002, p=0.044). In conclusion, there was a negative trend between Y:X ratio and PFOS in the Inuit, while there was no association between PFOA and the Y:X ratio in adult men.}}, author = {{Kvist, Linus and Giwercman, Yvonne and Jönsson, Bo A and Lindh, Christian and Bonde, Jens-Peter and Toft, Gunnar and Strucinski, Pawel and Pedersen, Henning S and Zvyezday, Valentyna and Giwercman, Aleksander}}, issn = {{1873-1708}}, language = {{eng}}, month = {{10}}, publisher = {{Elsevier}}, series = {{Reproductive Toxicology}}, title = {{Serum levels of perfluorinated compounds and sperm Y:X chromosome ratio in two European populations and in Inuit from Greenland.}}, url = {{https://lup.lub.lu.se/search/files/3855429/3222308.pdf}}, doi = {{10.1016/j.reprotox.2012.09.007}}, year = {{2012}}, }