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Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies : A Swedish nationwide prospective population-based cohort study

Cerqueiro Bybrant, Mara ; Grahnquist, Lena ; Örtqvist, Eva ; Andersson, Cecilia LU ; Forsander, Gun ; Elding Larsson, Helena LU ; Lernmark, Åke LU ; Ludvigsson, Johnny ; Marcus, Claude and Carlsson, Annelie LU , et al. (2018) In Autoimmunity 51(5). p.221-227
Abstract

OBJECTIVES: This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D).

PATIENTS AND METHODS: Dried blood spots and serum samples were taken at diagnosis from children <18 years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA).

RESULTS: Out of 2705 children diagnosed with T1D, 85 (3.1%) had... (More)

OBJECTIVES: This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D).

PATIENTS AND METHODS: Dried blood spots and serum samples were taken at diagnosis from children <18 years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA).

RESULTS: Out of 2705 children diagnosed with T1D, 85 (3.1%) had positive tTGA and 63 (2.3%) had borderline values. The prevalence of tTGA was higher in children with the HLA genotypes DQ2/2, DQ2/X or DQ2/8 compared to those with DQ8/8 or DQ8/X (p = .00001) and those with DQX/X (p ≤ .00001). No significant differences were found in relation to islet autoantibodies or age at diagnosis, but the presence of tTGA was more common in girls than in boys (p = .018).

CONCLUSION: tTGA at T1D diagnosis (both positive and borderline values 5.4%) was higher in girls and in children homozygous for DQ2/2, followed by children heterozygous for DQ2. Only children with DQ2 and/or DQ8 had tTGA. HLA typing at the diagnosis of T1D can help to identify those without risk for CD.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
celiac disease, human leukocyte antigen, islet autoantibodies, tissue transglutaminase antibodies, Type 1 diabetes
in
Autoimmunity
volume
51
issue
5
pages
221 - 227
publisher
Taylor & Francis
external identifiers
  • scopus:85057317962
  • pmid:30444426
ISSN
0891-6934
DOI
10.1080/08916934.2018.1494160
language
English
LU publication?
yes
id
b70f95a9-b910-4421-a76c-154fc377b97e
date added to LUP
2018-12-06 09:40:40
date last changed
2021-02-17 05:19:20
@article{b70f95a9-b910-4421-a76c-154fc377b97e,
  abstract     = {<p>OBJECTIVES: This study explored the association between tissue transglutaminase autoantibody (tTGA), high-risk human leucocyte antigen (HLA) genotypes and islet autoantibodies in children with newly diagnosed type 1 diabetes (T1D).</p><p>PATIENTS AND METHODS: Dried blood spots and serum samples were taken at diagnosis from children &lt;18 years of age participating in Better Diabetes Diagnosis (BDD), a Swedish nationwide prospective cohort study of children newly diagnosed with T1D. We analyzed tTGA, high-risk HLA DQ2 and DQ8 (DQX is neither DQ2 nor DQ8) and islet auto-antibodies (GADA, IA-2A, IAA, and three variants of Zinc transporter; ZnT8W, ZnT8R, and ZnT8QA).</p><p>RESULTS: Out of 2705 children diagnosed with T1D, 85 (3.1%) had positive tTGA and 63 (2.3%) had borderline values. The prevalence of tTGA was higher in children with the HLA genotypes DQ2/2, DQ2/X or DQ2/8 compared to those with DQ8/8 or DQ8/X (p = .00001) and those with DQX/X (p ≤ .00001). No significant differences were found in relation to islet autoantibodies or age at diagnosis, but the presence of tTGA was more common in girls than in boys (p = .018).</p><p>CONCLUSION: tTGA at T1D diagnosis (both positive and borderline values 5.4%) was higher in girls and in children homozygous for DQ2/2, followed by children heterozygous for DQ2. Only children with DQ2 and/or DQ8 had tTGA. HLA typing at the diagnosis of T1D can help to identify those without risk for CD.</p>},
  author       = {Cerqueiro Bybrant, Mara and Grahnquist, Lena and Örtqvist, Eva and Andersson, Cecilia and Forsander, Gun and Elding Larsson, Helena and Lernmark, Åke and Ludvigsson, Johnny and Marcus, Claude and Carlsson, Annelie and Ivarsson, Sten A.},
  issn         = {0891-6934},
  language     = {eng},
  month        = {11},
  number       = {5},
  pages        = {221--227},
  publisher    = {Taylor & Francis},
  series       = {Autoimmunity},
  title        = {Tissue transglutaminase autoantibodies in children with newly diagnosed type 1 diabetes are related to human leukocyte antigen but not to islet autoantibodies : A Swedish nationwide prospective population-based cohort study},
  url          = {http://dx.doi.org/10.1080/08916934.2018.1494160},
  doi          = {10.1080/08916934.2018.1494160},
  volume       = {51},
  year         = {2018},
}