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Quantified small bowel motility in patients with ulcerative colitis and gastrointestinal symptoms : a pilot study

Tufvesson, Hanna LU ; Dreja, Julia ; Ekberg, Olle LU ; Leander, Peter LU ; Månsson, Sven LU and Ohlsson, Bodil LU (2020) In Acta Radiologica
Abstract

Background: Gastrointestinal (GI) symptoms are common in patients with ulcerative colitis (UC), even when the disease is in remission, possibly due to abnormalities in GI motility. Small bowel motility can be assessed globally and in specific intestinal regions during magnetic resonance enterography (MRE) using a displacement mapping technique. Purpose: To investigate whether small bowel motility in MRE differs between patients with UC and controls, and if altered motility correlates with GI symptoms. Material and Methods: In 2016–2018, patients who were admitted for MRE, regardless of clinical indication, were consecutively invited to the study. Healthy volunteers were recruited. The participants completed a questionnaire regarding GI... (More)

Background: Gastrointestinal (GI) symptoms are common in patients with ulcerative colitis (UC), even when the disease is in remission, possibly due to abnormalities in GI motility. Small bowel motility can be assessed globally and in specific intestinal regions during magnetic resonance enterography (MRE) using a displacement mapping technique. Purpose: To investigate whether small bowel motility in MRE differs between patients with UC and controls, and if altered motility correlates with GI symptoms. Material and Methods: In 2016–2018, patients who were admitted for MRE, regardless of clinical indication, were consecutively invited to the study. Healthy volunteers were recruited. The participants completed a questionnaire regarding GI symptoms and relevant clinical data were reviewed in the medical records. The dynamic imaging series obtained during MRE were sent for motility mapping and a motility index (MI) was calculated in jejunum, ileum and terminal ileum in all participants. Results: In total, 224 patients and healthy volunteers were enrolled in the study. Fifteen were diagnosed with UC and 22 were considered healthy controls. In UC, the prevalence of GI symptoms was higher than in controls (P < 0.001), both in remission and in active disease. There was no correlation between GI symptoms and small bowel motility in UC. Jejunal motility was lower in UC than in controls (P = 0.049). Conclusion: Jejunal motility is decreased in UC compared with healthy controls, but there is no relationship between small bowel motility and GI symptoms in UC.

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author
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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Gastrointestinal motility, magnetic resonance imaging, motility index, small intestine, ulcerative colitis
in
Acta Radiologica
publisher
SAGE Publications
external identifiers
  • scopus:85089472758
  • pmid:32806922
ISSN
0284-1851
DOI
10.1177/0284185120946713
language
English
LU publication?
yes
id
b766ac5b-076c-430b-afb7-500088d35e52
date added to LUP
2020-08-28 08:07:49
date last changed
2020-11-24 01:12:45
@article{b766ac5b-076c-430b-afb7-500088d35e52,
  abstract     = {<p>Background: Gastrointestinal (GI) symptoms are common in patients with ulcerative colitis (UC), even when the disease is in remission, possibly due to abnormalities in GI motility. Small bowel motility can be assessed globally and in specific intestinal regions during magnetic resonance enterography (MRE) using a displacement mapping technique. Purpose: To investigate whether small bowel motility in MRE differs between patients with UC and controls, and if altered motility correlates with GI symptoms. Material and Methods: In 2016–2018, patients who were admitted for MRE, regardless of clinical indication, were consecutively invited to the study. Healthy volunteers were recruited. The participants completed a questionnaire regarding GI symptoms and relevant clinical data were reviewed in the medical records. The dynamic imaging series obtained during MRE were sent for motility mapping and a motility index (MI) was calculated in jejunum, ileum and terminal ileum in all participants. Results: In total, 224 patients and healthy volunteers were enrolled in the study. Fifteen were diagnosed with UC and 22 were considered healthy controls. In UC, the prevalence of GI symptoms was higher than in controls (P &lt; 0.001), both in remission and in active disease. There was no correlation between GI symptoms and small bowel motility in UC. Jejunal motility was lower in UC than in controls (P = 0.049). Conclusion: Jejunal motility is decreased in UC compared with healthy controls, but there is no relationship between small bowel motility and GI symptoms in UC.</p>},
  author       = {Tufvesson, Hanna and Dreja, Julia and Ekberg, Olle and Leander, Peter and Månsson, Sven and Ohlsson, Bodil},
  issn         = {0284-1851},
  language     = {eng},
  month        = {08},
  publisher    = {SAGE Publications},
  series       = {Acta Radiologica},
  title        = {Quantified small bowel motility in patients with ulcerative colitis and gastrointestinal symptoms : a pilot study},
  url          = {http://dx.doi.org/10.1177/0284185120946713},
  doi          = {10.1177/0284185120946713},
  year         = {2020},
}